Why is "Α-Catenin" trending?
Latest news, Wikipedia summary, and trend analysis.
Trend Analysis
- Ranking position: #
- Date: 2026-03-28 16:21:22
This topic has appeared in the trending rankings 1 time(s) in the past year. While it does not trend frequently, its appearance suggests a renewed or concentrated surge of public interest.
Based on Wikipedia pageviews and search interest, this topic gained significant attention on the selected date.
Trend Insight
This topic is not currently in the ranking.
Wikipedia Overview
α-Catenin (alpha-catenin) functions as the primary protein link between cadherins and the actin cytoskeleton. It has been reported that the actin binding proteins vinculin and α-actinin can bind to alpha-catenin. It has been suggested that alpha-catenin does not bind with high affinity to both actin filaments and the E-cadherin-beta-catenin complex at the same time. It has been observed that when α-catenin is not in a molecular complex with β-catenin, it dimerizes and functions to regulate actin filament assembly, possibly by competing with Arp2/3 protein. However, a protein complex including a cadherin, actin, β-catenin and α-catenin has not been isolated.
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Trending Topic Today
Search Interest Perspective
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A conformational change in α-catenin’s actin-binding domain governs adherens junction maturation - nature.com
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β-catenin condensation facilitates clustering of the cadherin/catenin complex and formation of nascent cell-cell junctions - nature.com
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The α-Catenin mechanosensing M region is required for cell adhesion during tissue morphogenesis - rupress.org
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Direct single-molecule quantification reveals unexpectedly high mechanical stability of vinculin—talin/α-catenin linkages - Science | AAAS
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α-Catenin mediates initial E-cadherin-dependent cell–cell recognition and subsequent bond strengthening - PNAS
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Can 1000 Reviews Be Wrong? Actin, α-Catenin, and Adherens Junctions - ScienceDirect.com
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A Polarized Epithelium Organized by β- and α-Catenin Predates Cadherin and Metazoan Origins - Science | AAAS
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Distinct inter-domain interactions of dimeric versus monomeric α-catenin link cell junctions to filaments - nature.com
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α-catenin switches between a slip and an asymmetric catch bond with F-actin to cooperatively regulate cell junction fluidity - nature.com
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Actin-dependent α-catenin oligomerization contributes to adherens junction assembly - nature.com
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α-Catenin levels determine direction of YAP/TAZ response to autophagy perturbation - nature.com
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Force-dependent allostery of the α-catenin actin-binding domain controls adherens junction dynamics and functions - nature.com
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Force-dependent conformational switch of α-catenin controls vinculin binding - nature.com
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α-Catenin as a tension transducer that induces adherens junction development - nature.com
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Real-time TIRF observation of vinculin recruitment to stretched α-catenin by AFM - nature.com
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Loss of α-catenin elicits a cholestatic response and impairs liver regeneration - nature.com
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α-catenin: at the junction of intercellular adhesion and actin dynamics - nature.com
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Mechano-adaptive sensory mechanism of α-catenin under tension - nature.com
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Monomeric α-catenin links cadherin to the actin cytoskeleton - nature.com
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ZO-1 regulates the migration of mesenchymal stem cells in cooperation with α-catenin in response to breast tumor cells - nature.com
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An α-catenin déjà vu - nature.com
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α-Catenin acetylation is essential for its stability and blocks its tumor suppressor effects in breast cancer through Yap1 - nature.com
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Variable Nuclear Localization of α-Catenin in Colorectal Carcinoma - nature.com
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Centralspindlin and α-catenin regulate Rho signalling at the epithelial zonula adherens - nature.com
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Alternative molecular mechanisms for force transmission at adherens junctions via β-catenin-vinculin interaction - nature.com
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VASP, zyxin and TES are tension-dependent members of Focal Adherens Junctions independent of the α-catenin-vinculin module - nature.com
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Impaired formation of homotypic cell-in-cell structures in human tumor cells lacking alpha-catenin expression - nature.com
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Nanoscale dynamics of the cadherin–catenin complex bound to vinculin revealed by neutron spin echo spectroscopy - PNAS
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αE-catenin is an autoinhibited molecule that coactivates vinculin - PNAS
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Stem Cell Proliferation in the Skin: α-Catenin Takes Over the Hippo Pathway - Science | AAAS
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α-Catenin Is a Tumor Suppressor That Controls Cell Accumulation by Regulating the Localization and Activity of the Transcriptional Coactivator Yap1 - Science | AAAS
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Cadherins and catenins in cancer: connecting cancer pathways and tumor microenvironment - Frontiers
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Binding partner- and force-promoted changes in αE-catenin conformation probed by native cysteine labeling - nature.com
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EPLIN mediates linkage of the cadherin–catenin complex to F-actin and stabilizes the circumferential actin belt - PNAS
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α-catenin acts as a tumour suppressor in E-cadherin-negative basal-like breast cancer by inhibiting NF-κB signalling - nature.com
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α-E-Catenin Inactivation Disrupts the Cardiomyocyte Adherens Junction, Resulting in Cardiomyopathy and Susceptibility to Wall Rupture | Circulation - American Heart Association Journals
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αE-catenin inhibits YAP/TAZ activity to regulate signalling centre formation during tooth development - nature.com
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β-Catenin: A Pivot between Cell Adhesion and Wnt Signalling - ScienceDirect.com
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α-catenin mechanosensing for adherens junctions - nature.com
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Inhibition of β-catenin/B cell lymphoma 9 protein−protein interaction using α-helix–mimicking sulfono-γ-AApeptide inhibitors - PNAS
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Cell Biology: A Tense but Good Day for Actin at Cell–Cell Junctions - ScienceDirect.com
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ARHGAP10 is necessary for α-catenin recruitment at adherens junctions and for Listeria invasion - nature.com
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Direct single-molecule quantification reveals unexpectedly high mechanical stability of vinculin—talin/α-catenin linkages - Science | AAAS
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α-helix bundle mechanical stability. - PLOS
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Modulation of α -catenin Tyr phosphorylation by SHP2 positively effects cell transformation induced by the constitutively active FGFR3 - nature.com
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Deciphering the mechanoresponsive role of β-catenin in keratoconus epithelium - nature.com
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An intrinsically labile α-helix abutting the BCL9-binding site of β-catenin is required for its inhibition by carnosic acid - nature.com
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An optochemical tool for light-induced dissociation of adherens junctions to control mechanical coupling between cells - nature.com
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Chromosome 5q deletion and epigenetic suppression of the gene encoding α-catenin ( CTNNA1 ) in myeloid cell transformation - nature.com
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Stabilisation of β-Catenin Downstream of T Cell Receptor Signalling - PLOS
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N-Cadherin Dependent Collective Cell Invasion of Prostate Cancer Cells Is Regulated by the N-Terminus of α-Catenin - PLOS
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Role of E-Cadherin, α-, β-, and γ-Catenins, and p120 (Cell Adhesion Molecules) in Prolactinoma Behavior - nature.com
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Vinculin forms a directionally asymmetric catch bond with F-actin - Science | AAAS
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Expression of α -catenin in α -catenin-deficient cells results in a reduced proliferation in three-dimensional multicellular spheroids but not in two-dimensional monolayer cultures - nature.com
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β-catenin is a molecular switch that regulates transition of cell-cell adhesion to fusion - nature.com
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Contact inhibition disrupted by EGTA followed by EGF+FGF-2 leads to EMT. - PLOS
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Quantifying cadherin mechanotransduction machinery assembly/disassembly dynamics using fluorescence covariance analysis - nature.com
Why This Topic Is Trending
This topic has recently gained attention due to increased public interest. Search activity and Wikipedia pageviews suggest growing global engagement.
Search Interest & Related Topics
Search interest data over the past 12 months indicates that this topic periodically attracts global attention. Sudden spikes often correlate with major news events, public statements, or geopolitical developments.