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This topic has appeared in the trending rankings 1 time(s) in the past year. While it does not trend frequently, its appearance suggests a renewed or concentrated surge of public interest.
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1-Methyl-2-iodo-LSD entered the ranking for the first time today at position #. This is its highest position ever recorded.
This topic has appeared in the English Wikipedia rankings 1 time. It first appeared on 2026-03-13 and was most recently seen on 2026-03-13.
1-Methyl-2-iodo-LSD (MIL) is a serotonin receptor modulator of the lysergamide family related to lysergic acid diethylamide (LSD). It is the 1-methyl derivative of 2-iodo-LSD (IOL). Extensive metabolism of other 1-methylated lysergamides to their secondary amine derivatives, for instance methysergide (1-methylmethylergometrine) conversion into methylergometrine, has been observed. The properties and effects of MIL in humans are unknown. However, a radiolabeled form of MIL, 1-methyl-2-[125I]iodo-LSD ([125I]-MIL), as well as the analogue 1-ethyl-2-[125I]iodo-LSD ([125I]-EIL), have been developed for use as presumably non-hallucinogenic agents in imaging of serotonin receptors. [125I]-MIL has much greater selectivity for serotonin 5-HT2 receptors over dopamine receptors compared to LSD. MIL and [125I]-MIL were first described in the scientific literature by Beth J. Hoffman and colleagues by 1985.
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