Why is "12-O-Tetradecanoylphorbol-13-acetate" trending?
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- Date: 2026-03-16 01:27:51
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Wikipedia Overview
12-O-Tetradecanoylphorbol-13-acetate (TPA), also commonly known as tetradecanoylphorbol acetate, tetradecanoyl phorbol acetate, and phorbol 12-myristate 13-acetate (PMA) is a diester of phorbol. It is a potent tumor promoter often employed in biomedical research to activate the signal transduction enzyme protein kinase C (PKC). The effects of TPA on PKC result from its similarity to one of the natural activators of classic PKC isoforms, diacylglycerol. TPA is a small molecule drug.
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Search Interest Perspective
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12-O-Tetradecanoylphorbol-13-acetate increases cardiomyogenesis through PKC/ERK signaling - Nature
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Coxiella burnetii: A model system to study host–pathogen interaction and zoonotic infectious diseases. - PLOS
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12-O-Tetradecanoylphorbol-13-acetate (TPA) is anti-tumorigenic in liver cancer cells via inhibiting YAP through AMOT - Nature
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Aqueous extract of Anisomeles indica and its purified compound exerts anti-metastatic activity through inhibition of NF-κB/AP-1-dependent MMP-9 activation in human breast cancer MCF-7 cells - ScienceDirect.com
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Heat shock protein 90 inhibitor RGRN-305 potently attenuates skin inflammation - Frontiers
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Oncology Reports - Spandidos Publications
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Antibodies to Butyrate-Inducible Antigens of Kaposi's Sarcoma–Associated Herpesvirus in Patients with HIV-1 Infection - The New England Journal of Medicine
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Delayed activation of PPARγ by LPS and IFN-γ attenuates the oxidative burst in macrophages - Wiley
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Development of a Viral Induction Study for Cell Bank Characterization - Genetic Engineering and Biotechnology News
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7th-Grader Finds Cancer-Fighting Chemical in Green Tea - Olive Oil Times
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Vav Proteins' Role in Skin Cancer - PLOS
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JNK interacting protein 1 (JIP-1) protects LNCaP prostate cancer cells from growth arrest and apoptosis mediated by 12- 0 -tetradecanoylphorbol-13-acetate (TPA) - Nature
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Annexin V inhibits the 12- O -tetradecanoylphorbol-13-acetate-induced activation of Ras/extracellular signal-regulated kinase (ERK) signaling pathway upstream of Shc in MCF-7 cells - Nature
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Mitochondrial targeting of JNK/SAPK in the phorbol ester response of myeloid leukemia cells - Nature
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Novel function of the chromosome 7 open reading frame 41 gene to promote leukemic megakaryocyte differentiation by modulating TPA-induced signaling - Nature
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Dual-directional epi-genotoxicity assay for assessing chemically induced epigenetic effects utilizing the housekeeping TK gene | Scientific Reports - Nature
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The loss of Tm7sf gene accelerates skin papilloma formation in mice - Nature
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ERK/c-Jun Recruits Tet1 to Induce Zta Expression and Epstein-Barr Virus Reactivation through DNA Demethylation - Nature
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Improved multiparametric scrape loading-dye transfer assay for a simultaneous high-throughput analysis of gap junctional intercellular communication, cell density and viability - Nature
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The regulatory domain of protein kinase Cθ localises to the Golgi complex and induces apoptosis in neuroblastoma and Jurkat cells | Cell Death & Differentiation - Nature
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Isolation and characterization of 1-palmitoyl-2-linoleoyl- sn -glycerol as a hormogonium-inducing factor (HIF) from the coralloid roots of Cycas revoluta (Cycadaceae) - Nature
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Anti-inflammatory Activity of Some Extracts and Isolates from Leonotis nepetaefolia on TPA-induced Edema Model - SciELO México
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Shea butter for skin cancer, typhoid fever - The Guardian Nigeria News
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