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The first European contact in 1492 started an influx of communicable diseases into the Caribbean. Diseases originating in the Old World (Afro-Eurasia) came to the New World for the first time, resulting in demographic and sociopolitical changes due to the Columbian Exchange from the late 15th century onwards. While some of the indigenous died of disease, others died of harsh working conditions. These working conditions were enforced because of the sugar cane in the area. The colonists were realizing that the number of people working was decreasing quickly, so they brought enslaved Africans to work there. These Africans brought more disease to the indigenous, killing more of them. The Indigenous peoples of the Americas had little immunity to the predominantly Old World diseases, resulting in significant loss of life and contributing to their enslavement and exploitation perpetrated by the European colonists. Waves of enslaved Africans were brought to replace the dwindling Indigenous populations, solidifying the position of disease in triangular trade.
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