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The 1675–1676 Malta plague epidemic was a major outbreak of plague on the island of Malta, then ruled by the Order of St John. It occurred between December 1675 and August 1676, and resulted in approximately 11,300 deaths, making it the deadliest epidemic in Maltese history. Most deaths were in the urban areas, including the capital Valletta and the Three Cities, which had a mortality rate of about 41%. In the rural settlements, the mortality rate was 6.9%.
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