Why is "17α-hydroxylase" trending?
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- Date: 2026-03-30 22:43:39
This topic has appeared in the trending rankings 1 time(s) in the past year. While it does not trend frequently, its appearance suggests a renewed or concentrated surge of public interest.
Based on Wikipedia pageviews and search interest, this topic gained significant attention on the selected date.
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Wikipedia Overview
Cytochrome P450 17A1 is an enzyme of the hydroxylase type that in humans is encoded by the CYP17A1 gene on chromosome 10. It is ubiquitously expressed in many tissues and cell types, including the zona reticularis and zona fasciculata of the adrenal cortex as well as gonadal tissues. It has both 17α-hydroxylase and 17,20-lyase activities, and is a key enzyme in the steroidogenic pathway that produces progestins, mineralocorticoids, glucocorticoids, androgens, and estrogens. More specifically, the enzyme acts upon pregnenolone and progesterone to add a hydroxyl (-OH) group at carbon 17 position (C17) of the steroid D ring, or acts upon 17α-hydroxyprogesterone and 17α-hydroxypregnenolone to split the side-chain off the steroid nucleus.
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Search Interest Perspective
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Novel estrogen-related gene variants identified by whole-exome sequencing in pregnancy-associated intrahepatic cholestasis - Frontiers
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-lyase inhibitor abiraterone acetate (CB7630) in patients with prostate cancer - nature.com
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Hypogonadism and Mineralocorticoid Excess | NEJM - NEJM
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Case report: 17α− hydroxylase deficiency due to a hotspot variant and a novel compound heterozygous variant in the CYP17A1 gene of five Chinese patients - Frontiers
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Assessment of the potential of polyphenols as a CYP17 inhibitor free of adverse corticosteroid elevation - ScienceDirect.com
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Genetics of P450 oxidoreductase: Sequence variation in 842 individuals of four ethnicities and activities of 15 missense mutations - PNAS
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The Steroid Signature of Fasting in Young Women - Endocrine Society
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Glioblastoma cells express crucial enzymes involved in androgen synthesis: 3β-hydroxysteroid dehydrogenase, 17-20α-hydroxylase, 17β-hydroxysteroid dehydrogenase and 5α-reductase - Wiley Online Library
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Nanoparticles with curcumin and piperine modulate steroid biosynthesis in prostate cancer - nature.com
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Reply to Flück et al.: Alternative androgen pathway biosynthesis drives fetal female virilization in P450 oxidoreductase deficiency - PNAS
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Decreases in Ovarian Cytochrome P450c17α Activity and Serum Free Testosterone after Reduction of Insulin Secretion in Polycystic Ovary Syndrome - NEJM
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Corticosteroid Biosynthesis Revisited: No Direct Hydroxylation of Pregnenolone by Steroid 21-Hydroxylase - Frontiers
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CYP17A1 deficient XY mice display susceptibility to atherosclerosis, altered lipidomic profile and atypical sex development - nature.com
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Targeting of CYP17A1 Lyase by VT-464 Inhibits Adrenal and Intratumoral Androgen Biosynthesis and Tumor Growth of Castration Resistant Prostate Cancer - nature.com
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High carrier frequency of a nonsense p.Trp230* variant in HSD3B2 gene in Ossetians - Frontiers
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Biosynthesis and biological action of pineal allopregnanolone - Frontiers
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Promising Tools in Prostate Cancer Research: Selective Non-Steroidal Cytochrome P450 17A1 Inhibitors - nature.com
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Overview of Monogenic or Mendelian Forms of Hypertension - Frontiers
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CYP17 blockade by abiraterone: further evidence for frequent continued hormone-dependence in castration-resistant prostate cancer - nature.com
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7α-Hydroxypregnenolone, a New Key Regulator of Locomotor Activity of Vertebrates: Identification, Mode of Action, and Functional Significance - Frontiers
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Novel Lead for the Design of Drugs Against Prostate Cancer and Polycystic Ovary Syndrome – Beyond the Abstract - UroToday
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Normal Spermatogenesis in a Man with Mutant Luteinizing Hormone - NEJM
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Cytochrome P450 Oxidoreductase Deficiency in Three Patients Initially Regarded as Having 21-Hydroxylase Deficiency and/or Aromatase Deficiency: Diagnostic Value of Urine Steroid Hormone Analysis - nature.com
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Occurrence and conversion of progestogens and androgens are conserved in land plants - Wiley
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Sporadic solitary aldosterone- and cortisol-co-secreting adenomas: endocrine, histological and genetic findings in a subtype of primary aldosteronism - nature.com
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Trick or Treat? Licorice-Induced Hypokalemia: A Case Report - Cureus
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Impact of ACTH Signaling on Transcriptional Regulation of Steroidogenic Genes - Frontiers
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Synthesis of sex hormone-derived modified steroids possessing antiproliferative activity - ScienceDirect.com
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Abiraterone: New Drug in the Treatment of Metastatic Castration-resistant Prostate Cancer - The ASCO Post
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Expression of steroidogenic enzymes and metabolism of steroids in COS-7 cells known as non-steroidogenic cells - nature.com
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Potential role of increased oxygenation in altering perinatal adrenal steroidogenesis - nature.com
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Decrease in the Expression of the 3β-Hydroxysteroid Dehydrogenase Gene in Human Adrenal Tissue during Prepuberty and Early Puberty: Implications for the Mechanism of Adrenarche - nature.com
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AUA 2012 - mCRPC in focus: Androgen biosynthesis inhibition and metastatic castration-resistant prostate cancer, clinical insights from the Clinical Industry Theater presentation by Judd Moul, MD - UroToday
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Dynamic change of estrogen and progesterone metabolites in human urine during pregnancy - nature.com
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Autoimmune addison disease and premature ovarian failure - nature.com
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The Effect of Soy Isoflavones on Steroid Metabolism - Frontiers
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Abiraterone-Induced Secondary Hypertension: Two Wrongs Don’t Make a Right - Cureus
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Expression of SET Protein in the Ovaries of Patients with Polycystic Ovary Syndrome - Wiley Online Library
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Gene expression and functional abnormalities in XX/ Sry Leydig cells - nature.com
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Genentech Acquires Seragon – Selective Estrogen Receptor Degraders for breast cancer - TLTC Blogs |
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Design for life | Feature - Chemistry World
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Dihydrotestosterone synthesis pathways from inactive androgen 5α-androstane-3β,17β-diol in prostate cancer cells: Inhibition of intratumoural 3β-hydroxysteroid dehydrogenase activities by abiraterone - nature.com
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Unusual case: Woman in Hubei possesses male chromosomal characteristics - China Daily
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