Why is "17β-estradiol" trending?
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Trend Analysis
- Ranking position: #
- Date: 2026-04-08 22:33:19
This topic has appeared in the trending rankings 1 time(s) in the past year. While it does not trend frequently, its appearance suggests a renewed or concentrated surge of public interest.
Based on Wikipedia pageviews and search interest, this topic gained significant attention on the selected date.
Trend Insight
17β-estradiol entered the ranking for the first time today at position #. This is its highest position ever recorded.
Wikipedia Overview
Estradiol (E2), also called oestrogen, oestradiol, is an estrogen steroid hormone and the major female sex hormone. It is involved in the regulation of female reproductive cycles such as estrous and menstrual cycles. Estradiol is responsible for the development of female secondary sexual characteristics such as the breasts, widening of the hips and a female pattern of fat distribution. It is also important in the development and maintenance of female reproductive tissues such as the mammary glands, uterus and vagina during puberty, adulthood and pregnancy. It also has important effects in many other tissues including bone, fat, skin, liver, and the brain.
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Differential effects of 17β-estradiol on knee and temporomandibular joints in ovariectomized rats - Nature
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Clinical outcomes of different 17β-estradiol drug regimens and their impact on endometrial receptivity - Frontiers
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Journal of Neuroendocrinology | BSN Journal - Wiley Online Library
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Role of 17β-estradiol injection on growth, physiology, and reproductive performance in male goldfish ( Carassius auratus ) with or without female interaction - Nature
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Chronic 17β-estradiol treatment improves negative valence, anhedonic profile, and social interactions in ovariectomized, middle-aged female rats - Frontiers
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Overlooked hormone may be deadly driver of postmenopausal breast cancer in women with obesity - Medical Xpress
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Tailored microenvironment of functional DNA enables highly robust blood estradiol tests - ScienceDirect.com
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17β estradiol activates autophagy and attenuates homocysteine mediated inflammation in endothelial cells through PI3K AKT MTOR signaling | Scientific Reports - Nature
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Estrogen signaling processes in fibroblasts: a scoping review - Frontiers
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Effects of 17β-estradiol and equilin on atherosclerosis development in female Apoeshl mice | Scientific Reports - Nature
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Multidimensional regulation of estrogen signaling in pelvic floor connective tissue homeostasis and remodeling - Frontiers
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Estrogen modulates reward prediction errors and reinforcement learning - Nature
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The estrogen–brain interface in neuroinflammation: a multidimensional mechanistic insight - Frontiers
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Dihydrotestosterone and 17β-estradiol modulate TMJ osteoarthritis development and reveal sex-specific differences in pathogenesis - Nature
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Diversity of estrogen biodegradation pathways and application in environmental bioremediation - Frontiers
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Seasonal dynamics of plasma estradiol 17β level, gonadosomatic index, and ovarian development in female golden trevally ( Gnathanodon speciosus - Nature
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Estrogen, menopause, and Alzheimer’s disease: understanding the link to cognitive decline in women - Frontiers
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Salivary hormonal analysis as a tool for skeletal maturity assessment - Nature
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Effect of environmental factors on laccase-mediated 17β-estradiol coupling reaction - Nature
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Multiple oestradiol functions inhibit ferroptosis and acute kidney injury - Nature
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Chapter 3. Impact of estrogens on hemostasis - Frontiers
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Metalloestrogens and Breast Cancer: Endocrine Disruption Insights - European Society of Medicine
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A framework for safe estradiol modulation in male bipolar disorder: theoretical justification for SERM-enabled adjunctive therapy - Frontiers
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Sex differences in G protein-coupled estrogen receptor-mediated mechanisms in preclinical models of anxiety and fear - Frontiers
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Estradiol pauses microtubule growth without increased incidence of catastrophe events - Nature
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Menopause-induced 17β-estradiol and progesterone loss increases senescence markers, matrix disassembly and degeneration in mouse cartilage - Nature
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Effect of environmentally relevant concentrations of estrogens on the aggressive response of male zebrafish - Frontiers
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Complex Interplay Between Estrogen and Aging via Lipid Metabolism and Inflammation Forms the Novel Treatment Strategies for Atherosclerosis - Wiley
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Long-QT mutations in KCNE1 modulate the 17β-estradiol response of Kv7.1/KCNE1 - Science | AAAS
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Avoiding touching until 60 min—contamination of transdermal estradiol gel after physical contact - Frontiers
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17β-estradiol status alters NMDAR function and antipsychotic-like activity in female rats | Molecular Psychiatry - Nature
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The truth about 17-beta estradiol: menopause beyond “old wives’ tales” - Frontiers
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Estrogen regulates duodenal calcium absorption and improves postmenopausal osteoporosis by the effect of ERβ on PMCA1b - Nature
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Estrogen Shapes Dopamine Reward Learning - Neuroscience News
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Interferon Genes Are Influenced by 17β-Estradiol in SLE - Frontiers
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Systemically circulating 17β-estradiol enhances the neuroprotective effect of the smoking cessation drug cytisine in female parkinsonian mice - Nature
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The Diverse Roles of 17β-Estradiol in Non-Gonadal Tissues and Its Consequential Impact on Reproduction in Laying and Broiler Breeder Hens - Frontiers
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Microbiota alter metabolism and mediate neurodevelopmental toxicity of 17β-estradiol - Nature
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Effect of 17β-estradiol on a human vaginal Lactobacillus crispatus strain - Nature
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Estrogen-Based MHT Does Not Consistently Reduce Anxiety Symptoms in Midlife Women - Pharmacy Times
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Neuroprotective Effects of 17β-Estradiol Rely on Estrogen Receptor Membrane Initiated Signals - Frontiers
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17β-Estradiol Inhibits PCSK9-Mediated LDLR Degradation Through GPER/PLC Activation in HepG2 Cells - Frontiers
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17-beta estradiol prevents cardiac myocyte hypertrophy by regulating mitochondrial E3 ubiquitin ligase 1 - Nature
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17β-Estradiol promotes sex-specific dysfunction in isolated human arterioles - American Physiological Society Journal
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The molecular nature of the 17β-Estradiol binding site in the voltage- and Ca - Nature
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The prodrug DHED selectively delivers 17β-estradiol to the brain for treating estrogen-responsive disorders - Science | AAAS
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The Role of 17β-Estradiol and Estrogen Receptors in Regulation of Ca - Frontiers
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Variability of the response of human vaginal Lactobacillus crispatus to 17β-estradiol - Nature
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The impact of 17β-estradiol on the estrogen-deficient female brain: from mechanisms to therapy with hot flushes as target symptoms - Frontiers
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From mitochondria to sarcopenia: role of 17β-estradiol and testosterone - Frontiers
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Estrogen and viral infection - Frontiers
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Surprising hormone found to protect male brains from stress - PsyPost
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Intrapatient 16α-[18F]Fluoro-17β-Estradiol PET Heterogeneity as a Prognostic Factor for Endocrine Therapy Response and Survival in Patients with Estrogen Receptor–Positive Metastatic Breast Cancer - Journal of Nuclear Medicine
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Rapid modulation of synaptogenesis and spinogenesis by 17β-estradiol in primary cortical neurons - Frontiers
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Targeting 17β-estradiol biosynthesis in neural stem cells improves stroke outcome - Frontiers
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Estrogen and bacterial infection - Frontiers
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17β-Estradiol Induces Mitophagy Upregulation to Protect Chondrocytes via the SIRT1-Mediated AMPK/mTOR Signaling Pathway - Frontiers
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Effects of high and low 17β-estradiol doses on focal cerebral ischemia in rats | Scientific Reports - Nature
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Aspirin Suppresses Aromatase-Mediated Estrogen Biosynthesis to Alleviate Polycystic Ovary Syndrome by the Inhibition of Adenylate Cyclase - Wiley
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Treatment with an orally bioavailable prodrug of 17β-estradiol alleviates hot flushes without hormonal effects in the periphery - Nature
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Prevention of Fatty Streak Formation of 17β-Estradiol Is Not Mediated by the Production of Nitric Oxide in Apolipoprotein E– Deficient Mice - American Heart Association Journals
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In vivo brain estrogen receptor density by neuroendocrine aging and relationships with cognition and symptomatology - Nature
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17β -Estradiol Differentially Regulates Stress Circuitry Activity in Healthy and Depressed Women - Nature
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The effects of 17b-estradiol in cancer are mediated by estrogen receptor signaling at the plasma membrane - Frontiers
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Ursolic acid modulates estrogen conversion to relieve inflammation in metabolic dysfunction-associated steatotic liver disease via HSD17B14 - EurekAlert!
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Protective Effect of 17β-Estradiol Upon Hippocampal Spine Density and Cognitive Function in an Animal Model of Vascular Dementia - Nature
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Vastly extended drug release from poly(pro-17β-estradiol) materials facilitates in vitro neurotrophism and neuroprotection - Nature
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Fulvestrant May Falsely Increase 17β-Estradiol Levels in Immunoassays: A Case Report of a 57-Year-Old Postmenopausal Patient With Recurrent Estrogen Receptor-Positive Breast Cancer - Frontiers
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Immunomodulatory Effects of 17β‐Estradiol on Epithelial Cells during Bacterial Infections - Wiley Online Library
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Biodegradation of 17β-estradiol by Bacterial Co-culture Isolated from Manure - Nature
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Low Doses of 17β -Estradiol Rapidly Improve Learning and Increase Hippocampal Dendritic Spines - Nature
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17β-estradiol alleviated ferroptotic neuroinflammation by suppressing ATF4 in mouse model of Parkinson’s disease - Nature
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Highly sensitive colorimetric detection of 17β-estradiol using split DNA aptamers immobilized on unmodified gold nanoparticles - Nature
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Low Doses of 17α-Estradiol and 17β-Estradiol Facilitate, Whereas Higher Doses of Estrone and 17α- and 17β-Estradiol Impair, Contextual Fear Conditioning in Adult Female Rats | Neuropsychopharmacology - Nature
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17β-Estradiol and Progesterone Supplementation in Extremely Low-Birth-Weight Infants - Nature
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17β-Estradiol inhibits ER stress-induced apoptosis through promotion of TFII-I-dependent Grp78 induction in osteoblasts | Laboratory Investigation - Nature
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Effects of high and low 17β-estradiol doses on focal cerebral ischemia: negative results - Nature
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Summary: SNMMI Procedure Standard/EANM Practice Guideline for Estrogen Receptor Imaging of Patients with Breast Cancer Using 16α-[18F]Fluoro-17β-Estradiol PET - Journal of Nuclear Medicine
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iTRAQ-based quantitative proteomic analysis of the global response to 17β-estradiol in estrogen-degradation strain Pseudomonas putida SJTE-1 - Nature
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Mechanisms underlying the low-temperature adaptation of 17β-estradiol-degrading bacterial strain Rhodococcus sp. RCBS9: insights from physiological and transcriptomic analyses - Frontiers
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17β-Estradiol Regulates Glucose Metabolism and Insulin Secretion in Rat Islet β Cells Through GPER and Akt/mTOR/GLUT2 Pathway - Frontiers
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Estrogen receptor 1 signaling in hepatic stellate cells designates resistance to liver fibrosis - Nature
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17β-Estradiol Potentiates the Reinstatement of Cocaine Seeking in Female Rats: Role of the Prelimbic Prefrontal Cortex and Cannabinoid Type-1 Receptors | Neuropsychopharmacology - Nature
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F-Fluoro-17β-Estradiol PET as a Predictor of Disease Outcome in Endometrial Cancer: A Prospective Study - Journal of Nuclear Medicine
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17β-Estradiol inhibition of PPARγ-induced adipogenesis and adipocyte-specific gene expression - Nature
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Effects of 17β -Estradiol on Neuronal Cell Excitability and Neurotransmission in the Suprachiasmatic Nucleus of Rat - Nature
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Therapeutic Effects of 17β-Estradiol on Pelvic Organ Prolapse by Inhibiting Mfn2 Expression: An In Vitro Study - Frontiers
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Immunomodulatory role of estrogen in ischemic stroke: neuroinflammation and effect of sex - Frontiers
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The influence of 17β-estradiol plus norethisterone acetate treatment on markers of glucose and insulin metabolism in women: a systematic review and meta-analysis of randomized controlled trials - Frontiers
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17beta-estradiol counteracts neuropathic pain: a behavioural, immunohistochemical and proteomic investigation on sex-related differences in mice - Nature
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Dynamin II is required for 17β-estradiol signaling and autophagy-based ERα degradation - Nature
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Impact of conjugation strategies for targeting of antibodies in gold nanoparticles for ultrasensitive detection of 17β-estradiol - Nature
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Light-initiated chemiluminescent assay of 17β-estradiol metrological traceability system established by manufacturer according to ISO17511:2020 and basic performance evaluation performed by clinical end-users - Wiley Online Library
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The modulation of potassium channels by estrogens facilitates neuroprotection - Frontiers
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Estradiol metabolism by gut microbiota in women’s depression pathogenesis: inspiration from nature - Frontiers
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TLR4-mediated brain inflammation halts neurogenesis: impact of hormonal replacement therapy - Frontiers
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Estradiol-17β Injection Induces Ovulation in Llamas - Frontiers
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Neuroglobin upregulation induced by 17β -estradiol sequesters cytocrome c in the mitochondria preventing H - Nature
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17-β-estradiol reduces surface PD-L1 expression in estrogen receptor-positive breast cancer but not type 1 endometrial cancer cells - Wiley Online Library
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Gestational oral low-dose estradiol-17β induces altered DNA methylation of CDKN2D and PSAT1 in embryos and adult offspring | Scientific Reports - Nature
Why This Topic Is Trending
This topic has recently gained attention due to increased public interest. Search activity and Wikipedia pageviews suggest growing global engagement.
Search Interest & Related Topics
Search interest data over the past 12 months indicates that this topic periodically attracts global attention. Sudden spikes often correlate with major news events, public statements, or geopolitical developments.