Why is "17-OH-Pregnenolone" trending?
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Trend Analysis
- Ranking position: #
- Date: 2026-04-02 02:28:49
This topic has appeared in the trending rankings 1 time(s) in the past year. While it does not trend frequently, its appearance suggests a renewed or concentrated surge of public interest.
Based on Wikipedia pageviews and search interest, this topic gained significant attention on the selected date.
Trend Insight
This topic is not currently in the ranking.
Wikipedia Overview
17α-Hydroxypregnenolone is a pregnane (C21) steroid that is obtained by hydroxylation of pregnenolone at the C17α position. This step is performed by the mitochondrial cytochrome P450 enzyme 17α-hydroxylase (CYP17A1) that is present in the adrenal and gonads. Peak levels are reached in humans at the end of puberty and then decline. High levels are also achieved during pregnancy. It is also a known neuromodulator.
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Trending Topic Today
Search Interest Perspective
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Corticosteroid Biosynthesis Revisited: No Direct Hydroxylation of Pregnenolone by Steroid 21-Hydroxylase - Frontiers
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Cytochrome P450 Oxidoreductase Deficiency in Three Patients Initially Regarded as Having 21-Hydroxylase Deficiency and/or Aromatase Deficiency: Diagnostic Value of Urine Steroid Hormone Analysis - Nature
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Compensatory mechanisms that maintain androgen production in mice lacking key androgen biosynthetic enzymes - Wiley
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Non-human Papillomavirus Cervical Mucinous Adenocarcinoma in a Phenotypic Male with Congenital Adrenal Hyperplasia - Cureus
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ACTH Stimulation Tests and Plasma Dehydroepiandrosterone Sulfate Levels in Women with Hirsutism - NEJM
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Do Dehydroepiandrosterone (DHEA) and Its Sulfate (DHEAS) Play a Role in the Stress Response in Domestic Animals? - Frontiers
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Comparison of Serum Cortisol Concentrations in Preterm Infants With or Without Late-Onset Circulatory Collapse due to Adrenal Insufficiency of Prematurity - Nature
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Diagnostic value of total testosterone and free androgen index measured by LC–MS/MS for PCOS and insulin resistance - Wiley Online Library
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Dehydroepiandrosterone Biosynthesis, Role, and Mechanism of Action in the Developing Neural Tube - Frontiers
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Impaired Glucocorticoid Synthesis in Premature Infants Developing Chronic Lung Disease - Nature
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Isolated hypoaldosteronism managed by DOCP in a dog with chronic kidney disease and hypercortisolism - Wiley Online Library
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Black ginseng: a novel medicine for treating heart failure - Frontiers
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Decrease in the Expression of the 3β-Hydroxysteroid Dehydrogenase Gene in Human Adrenal Tissue during Prepuberty and Early Puberty: Implications for the Mechanism of Adrenarche - Nature
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Subtle perturbations of ovarian steroidogenesis in patients classified as Poseidon Group 3. Which consequences for therapeutic strategy? - Frontiers
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Stimulatory Effect of Intermittent Hypoxia on the Production of Corticosterone by Zona Fasciculata-Reticularis Cells in Rats - Nature
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Blood and adipose tissue steroid metabolomics and mRNA expression of steroidogenic enzymes in periparturient dairy cows differing in body condition - Nature
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7α-Hydroxypregnenolone, a key neuronal modulator of locomotion, stimulates upstream migration by means of the dopaminergic system in salmon - Nature
Why This Topic Is Trending
This topic has recently gained attention due to increased public interest. Search activity and Wikipedia pageviews suggest growing global engagement.
Search Interest & Related Topics
Search interest data over the past 12 months indicates that this topic periodically attracts global attention. Sudden spikes often correlate with major news events, public statements, or geopolitical developments.