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Why is "1721 Boston smallpox outbreak" trending?

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  • Date: 2026-03-30 08:17:18

This topic has appeared in the trending rankings 1 time(s) in the past year. While it does not trend frequently, its appearance suggests a renewed or concentrated surge of public interest.

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1721 Boston smallpox outbreak

Wikipedia Overview

In 1721, Boston experienced its worst outbreak of smallpox. 5,759 people out of around 10,600 in Boston were infected and 844 were recorded to have died between April 1721 and February 1722. The outbreak motivated Puritan minister Cotton Mather and physician Zabdiel Boylston to variolate hundreds of Bostonians as part of the Thirteen Colonies' earliest experiment with public inoculation. Their efforts would inspire further research for immunizing people from smallpox, placing the Massachusetts Bay Colony at the epicenter of the Colonies' first inoculation debate and changing Western society's medical treatment of the disease. The outbreak also altered social and religious public discourse about disease, as Boston's newspapers published various pamphlets opposing and supporting the inoculation efforts.

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