Why is "2'-O-methylation" trending?

Search Interest Perspective

• The Role of 2′‐O‐Methylation in Epitranscriptomic Regulation: Gene Expression, Physiological Functions and Applications - Azeem - 2025 - WIREs RNA - Wiley Interdisciplinary Reviews
• MultiV_Nm: a prediction method for 2′-O-methylation sites based on multi-view features - Frontiers
• A bifunctional snoRNA with separable activities in guiding rRNA 2’-O-methylation and scaffolding gametogenesis effectors - Nature
• Targeted RNA 2'-O-methylation for Regulating Telomerase Activity - Projects - Yu Lab - University of Rochester Medical Center
• Identification of FBLL1 as a neuron-specific RNA 2′-O-methyltransferase mediating neuronal differentiation - PNAS
• Small nucleolar RNA SNORD13H suppresses tumor progression via FBL-dependent 2'-O-methylation in hepatocellular carcinoma - Frontiers
• Modification of messenger RNA by 2′- O -methylation regulates gene expression in vivo - Nature
• Identification of sites of 2′-O-methylation vulnerability in human ribosomal RNAs by systematic mapping - Nature
• The Arabidopsis 2′-O-Ribose-Methylation and Pseudouridylation Landscape of rRNA in Comparison to Human and Yeast - Frontiers
• O -methylation in mRNA disrupts tRNA decoding during translation elongation - Nature
• A single 2′- O -methylation of ribosomal RNA gates assembly of a functional ribosome - Nature
• Nm-seq maps 2′- O -methylation sites in human mRNA with base precision - Nature
• Fractional 2′-O-methylation in the ribosomal RNA of Dictyostelium discoideum supports ribosome heterogeneity in Amoebozoa - Nature
• Germline NPM1 mutations lead to altered rRNA 2′-O-methylation and cause dyskeratosis congenita - Nature
• A PRC2-independent function for EZH2 in regulating rRNA 2′- O methylation and IRES-dependent translation - Nature
• LncRNA INHEG promotes glioma stem cell maintenance and tumorigenicity through regulating rRNA 2’-O-methylation - Nature
• SNORD88C guided 2′-O-methylation of 28S rRNA regulates SCD1 translation to inhibit autophagy and promote growth and metastasis in non-small cell lung cancer - Nature
• Ribose 2′- O -methylation provides a molecular signature for the distinction of self and non-self mRNA dependent on the RNA sensor Mda5 - Nature
• RNA 2′-O-methylation modification and its implication in COVID-19 immunity - Nature
• A metal ion orients SARS-CoV-2 mRNA to ensure accurate 2′- O methylation of its first nucleotide - Nature
• 2′-O methylation of the viral mRNA cap evades host restriction by IFIT family members - Nature
• SNORD11B-mediated 2′-O-methylation of primary let-7a in colorectal carcinogenesis - Nature
• O -Methyl-guanosine RNA fragments antagonize TLR7 and TLR8 to limit autoimmunity - Nature
• CMTr cap-adjacent 2′- O -ribose mRNA methyltransferases are required for reward learning and mRNA localization to synapses - Nature
• Correction: 2'-O-methylation of the mRNA cap protects RNAs from decapping and degradation by DXO - PLOS
• Box C/D snoRNA SNORD89 influences the occurrence and development of endometrial cancer through 2’- O -methylation modification of Bim - Nature
• Structural and biochemical insights into 2′-O-methylation at the 3′-terminal nucleotide of RNA by Hen1 - PNAS
• Natural evidence of coronaviral 2′-O-methyltransferase activity affecting viral pathogenesis via improved substrate RNA binding - Nature
• DeepOMe: A Web Server for the Prediction of 2′-O-Me Sites Based on the Hybrid CNN and BLSTM Architecture - Frontiers
• Structural analysis of human 2′- O -ribose methyltransferases involved in mRNA cap structure formation - Nature
• N7-Methylation of the Coronavirus RNA Cap Is Required for Maximal Virulence by Preventing Innate Immune Recognition - ASM Journals
• Highly efficient and safe genome editing by CRISPR-Cas12a using CRISPR RNA with a ribosyl-2′-O-methylated uridinylate-rich 3′-overhang in mouse zygotes - Nature
• The Biological Roles of tRNA Modifications - Projects - Phizicky Lab - University of Rochester Medical Center
• KtzJ-dependent serine activation and O -methylation by KtzH for kutznerides biosynthesis - Nature
• Discovery on how aggressive breast cancer controls protein production - Umeå universitet