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2,4,6-TMPEA-NBOMe, also known as ψ-2C-O-NBOMe or 26O-NBOMe as well as N-(2-methoxybenzyl)-2,4,6-trimethoxyphenethylamine, is a psychedelic drug of the phenethylamine, ψ-PEA, and N-benzylphenethylamine (NBOMe) families. It is the NBOMe derivative of ψ-2C-O (2,4,6-TMPEA). The drug is said to produce psychedelic effects such as visuals. It has been found to act as a potent serotonin 5-HT2A receptor partial agonist, with an EC50Tooltip half-maximal effective concentration of 1.7 nM and an EmaxTooltip maximal efficacy of 49%. 2,4,6-TMPEA-NBOMe was first described in the scientific literature in 2009. Subsequently, it was encountered as a novel designer drug in Russia in 2015. The drug is a controlled substance in Canada under phenethylamine blanket-ban language.
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