Why is "2-Hydroxyestrone" trending?
Latest news, Wikipedia summary, and trend analysis.
Trend Analysis
- Ranking position: #
- Date: 2026-04-13 09:13:07
This topic has appeared in the trending rankings 1 time(s) in the past year. While it does not trend frequently, its appearance suggests a renewed or concentrated surge of public interest.
Based on Wikipedia pageviews and search interest, this topic gained significant attention on the selected date.
Trend Insight
This topic is not currently in the ranking.
Wikipedia Overview
2-Hydroxyestrone (2-OHE1), also known as estra-1,3,5(10)-trien-2,3-diol-17-one, is an endogenous, naturally occurring catechol estrogen and a major metabolite of estrone and estradiol. It is formed irreversibly from estrone in the liver and to a lesser extent in other tissues via 2-hydroxylation mediated by cytochrome P450 enzymes, mainly the CYP3A and CYP1A subfamilies. 2-OHE1 is the most abundant catechol estrogen in the body.
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Trending Topic Today
Search Interest Perspective
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DIM Supplement Alters Estradiol Patch Metabolism - Conexiant
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The Effects of Diet and Exercise on Endogenous Estrogens and Subsequent Breast Cancer Risk in Postmenopausal Women - Frontiers
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Dynamic change of estrogen and progesterone metabolites in human urine during pregnancy - Nature
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Estrogen byproducts linked to survival in breast cancer patients - UNC Gillings School of Global Public Health
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Urinary estrogen metabolites and gastric cancer risk among postmenopausal women - Wiley Online Library
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DIM Supplements: Benefits, Side Effects, and Dosage - Healthline
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4-Hydroxyestrone, an Endogenous Estrogen Metabolite, Can Strongly Protect Neuronal Cells Against Oxidative Damage - Nature
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Scientists find a soup of suspects while probing milk’s link to cancer - Science News
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Association Between Estrogen Levels, Head and Neck Cancers | Newswise - Newswise
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CYP3A7*1C allele is associated with reduced levels of 2-hydroxylation pathway oestrogen metabolites - Nature
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Association between urine and serum estradiol levels in in vitro fertilization cycles - Nature
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Protection of HT22 neuronal cells against chemically-induced ferroptosis by catechol estrogens: protein disulfide isomerase as a mechanistic target - Nature
Why This Topic Is Trending
This topic has recently gained attention due to increased public interest. Search activity and Wikipedia pageviews suggest growing global engagement.
Search Interest & Related Topics
Search interest data over the past 12 months indicates that this topic periodically attracts global attention. Sudden spikes often correlate with major news events, public statements, or geopolitical developments.