Why is "21-hydroxylase" trending?
Latest news, Wikipedia summary, and trend analysis.
Trend Analysis
- Ranking position: #
- Date: 2026-03-07 05:29:21
This topic has appeared in the trending rankings 1 time(s) in the past year. While it does not trend frequently, its appearance suggests a renewed or concentrated surge of public interest.
Based on Wikipedia pageviews and search interest, this topic gained significant attention on the selected date.
Trend Insight
This topic is not currently in the ranking.
Wikipedia Overview
Steroid 21-hydroxylase is a protein that in humans is encoded by the CYP21A2 gene. The protein is an enzyme that hydroxylates steroids at the C21 position on the molecule. Naming conventions for enzymes are based on the substrate acted upon and the chemical process performed. Biochemically, this enzyme is involved in the biosynthesis of the adrenal gland hormones aldosterone and cortisol, which are important in blood pressure regulation, sodium homeostasis and blood sugar control. The enzyme converts progesterone and 17α-hydroxyprogesterone into 11-deoxycorticosterone and 11-deoxycortisol, respectively, within metabolic pathways which in humans ultimately lead to aldosterone and cortisol creation—deficiency in the enzyme may cause congenital adrenal hyperplasia.
Read more on Wikipedia →Related Topics
Trending Topic Today
Search Interest Perspective
-
Fertility in congenital adrenal hyperplasia due to 21-hydroxylase deficiency: a review - Frontiers
-
High precision characterization of RCCX rearrangements in a 21-hydroxylase deficiency Latin American cohort using oxford nanopore long read sequencing - Nature
-
Simple virilizing form of 21-hydroxylase deficiency presenting with renal Insufficiency and polycythemia: a case report - Frontiers
-
Two Distinct Endocrine Conditions in a Single Pediatric Patient: Congenital Adrenal Hyperplasia and Type 1 Diabetes Mellitus - Cureus
-
Genetics in Congenital Adrenal Hyperplasia Due to 21-Hydroxylase Deficiency and Clinical Implications - Endocrine Society
-
What Hormones Are Affected by CAH? - Cleveland Clinic Health Essentials
-
Congenital Adrenal Hyperplasia Due to 21-Hydroxylase Deficiency - The New England Journal of Medicine
-
High-fidelity long-read sequencing reveals a complex RCCX locus at the single-nucleotide level in Korean patients with congenital adrenal hyperplasia - medRxiv
-
Beyond endocrine features in non-classical congenital adrenal hyperplasia: a narrative review of psychoneuro-social perspectives in pediatric and adolescent patients - SpringerMedizin.de
-
Genetic diagnosis of CYP21A2-related CAH: adaptive sampling long-read sequencing is an accurate and scalable solution | European Journal of Human Genetics - Nature
-
Exploration of the potential of genomic editing in the treatment of congenital adrenal hyperplasia - Frontiers
-
Arterial stiffness and shortened QTc interval are associated with androgen and ACTH levels in classic congenital adrenal hyperplasia - Frontiers
-
Prenatal diagnosis and treatment of congenital adrenal hyperplasia owing to 21-hydroxylase deficiency - Nature
-
Case Report: Challenges of an extremely delayed diagnosis of classic congenital adrenal hyperplasia in a completely virilized 46,XX patient - Frontiers
-
Molecular Diagnosis of Steroid 21-Hydroxylase Deficiency: A Practical Approach - Frontiers
-
Monitoring treatment in pediatric patients with 21-hydroxylase deficiency - Frontiers
-
Neonatal Screening and Genotype-Phenotype Correlation of 21-Hydroxylase Deficiency in the Chinese Population - Frontiers
-
Editorial: Recent advances in diagnosis and treatment of congenital adrenal hyperplasia due to 21-hydroxylase deficiency - Frontiers
-
Characteristics of In2G Variant in Congenital Adrenal Hyperplasia Due to 21-Hydroxylase Deficiency - Frontiers
-
Long-Term Health Outcomes of Korean Adults With Classic Congenital Adrenal Hyperplasia Due to 21-Hydroxylase Deficiency - Frontiers
-
EMQN best practice guidelines for molecular genetic testing and reporting of 21-hydroxylase deficiency - Nature
-
Structure-based activity prediction of CYP21A2 stability variants: A survey of available gene variations - Nature
-
Corticosteroid Biosynthesis Revisited: No Direct Hydroxylation of Pregnenolone by Steroid 21-Hydroxylase - Frontiers
-
Two Siblings with the Same Severe Form of 21-Hydroxylase Deficiency But Different Growth and Menstrual Cycle Patterns - Frontiers
-
Case Report: Infant With Congenital Adrenal Hyperplasia and 47,XXY - Frontiers
-
Editorial: Rare forms of pediatric adrenal disorders: beyond congenital adrenal hyperplasia due to 21-hydroxylase deficiency - Frontiers
-
Recommendations for the diagnosis and treatment of classic forms of 21-hydroxylase-deficient congenital adrenal hyperplasia - Anales de Pediatría
-
Mitotane for 21-Hydroxylase Deficiency in an Infertile Man - The New England Journal of Medicine
-
Salt-Wasting Form of Congenital Adrenal Hyperplasia: A Case Report - Cureus
-
Toward Improving the Transition of Patients With Congenital Adrenal Hyperplasia From Pediatrics to Adult Healthcare in Japan - Frontiers
-
The chimeric CYP21P/CYP21 gene and 21-hydroxylase deficiency - Nature
-
Cardiovascular Health in Children and Adolescents With Congenital Adrenal Hyperplasia Due to 21-Hydroxilase Deficiency - Frontiers
-
Neurocrine Biosciences Announces Classic Congenital Adrenal Hyperplasia Supplement Published Today in The Journal of Clinical Endocrinology & Metabolism - PR Newswire
-
Phase 3 Trial of Crinecerfont in Pediatric Congenital Adrenal Hyperplasia - The New England Journal of Medicine
-
Congenital Adrenal Hyperplasia - The New England Journal of Medicine
-
Neurocrine Biosciences to Present New Phase 3 CAHtalyst™ Data in Adult and Pediatric Patients with CAH and Study Data for Modified-Release Hydrocortisone in Primary Adrenal Insufficiency and CAH at ENDO 2024 - PR Newswire
-
Case report: Management challenges of late diagnosed 17‐alpha hydroxylase deficiency - Wiley Online Library
-
Management of adolescents with congenital adrenal hyperplasia - The Lancet
-
Adrenal Lymphocytic Infiltration and Adrenocortical Tumors in a Patient with 21-Hydroxylase Deficiency - The New England Journal of Medicine
-
Screening for non-classic congenital adrenal hyperplasia in women: New insights using different immunoassays - Frontiers
-
Obesity and Cardiometabolic Risk Factors in Children and Young Adults With Non-classical 21-Hydroxylase Deficiency - Frontiers
-
Growth of Patients with 21-Hydroxylase Deficiency: An Analysis of the Factors Influencing Adult Height - Nature
-
Genotype Is Associated to the Degree of Virilization in Patients With Classic Congenital Adrenal Hyperplasia - Frontiers
-
After decades with only one option, new therapies emerge for congenital adrenal hyperplasia - Healio
-
Classic vs Nonclassic CAH: Types Explained - Mayo Clinic Press
-
Congenital adrenal hyperplasia due to 11-beta-hydroxylase deficiency: functional consequences of four CYP11B1 mutations - Nature
-
Case report: Development of central precocious puberty in a girl with late-diagnosed simple virilizing congenital adrenal hyperplasia complicated with Williams syndrome - Frontiers
-
Congenital adrenal hyperplasia is a very rare cause of adrenal incidentalomas in Sweden - Frontiers
-
Copy Number Variations in Genetic Diagnosis of Congenital Adrenal Hyperplasia Children - Frontiers
-
Identifying the First Val281L Mutation Causing Nonclassic Congenital Adrenal Hyperplasia in the Central-East Region of Tunisia - Cureus
-
A Cross-Sectional Study of Congenital Adrenal Hyperplasia - Cureus
-
Congenital Adrenal Hyperplasia Due to 21-Hydroxylase Deficiency - The New England Journal of Medicine
-
Adrenal steroid hormone responses to exercise under thermal stress: Potential role for nonclassic congenital adrenal hyperplasia in heat illness susceptibility - Wiley
-
Variant predictions in congenital adrenal hyperplasia caused by mutations in CYP21A2 - Frontiers
-
Tenascin-X—Discovery and Early Research - Frontiers
-
[Figure, Steroid Hormone Synthesis Pathways from...] - StatPearls - National Institutes of Health (.gov)
-
Polycystic Ovary Syndrome and NC-CAH: Distinct Characteristics and Common Findings. A Systematic Review - Frontiers
-
Cytochrome P450 Oxidoreductase Deficiency in Three Patients Initially Regarded as Having 21-Hydroxylase Deficiency and/or Aromatase Deficiency: Diagnostic Value of Urine Steroid Hormone Analysis - Nature
-
Role of the adrenal cortex in genital development | FSHS Project | Results in Brief | FP7 - CORDIS
-
The corpus callosum in people with congenital adrenal hyperplasia (CAH) - Nature
-
Molecular Genetic Analysis of Nonclassic Steroid 21-Hydroxylase Deficiency Associated with HLA-B14,DR1 - The New England Journal of Medicine
-
A unique haplotype of RCCX copy number variation: from the clinics of congenital adrenal hyperplasia to evolutionary genetics - Nature
-
Investigational Gene Therapy Fast Tracked for Congenital Adrenal Hyperplasia - Medical Professionals Reference
-
Restoration of adrenal steroidogenesis by adenovirus-mediated transfer of human cytochromeP450 21-hydroxylase into the adrenal gland of21-hydroxylase-deficient mice - Nature
-
Finding the needle in the genomic haystack with DRAGEN - Illumina
-
Reproductive Function and Fertility in Women with Congenital Adrenal Hyperplasia - European Medical Journal
-
A TNXB splice donor site variant as a cause of hypermobility type Ehlers–Danlos syndrome in patients with congenital adrenal hyperplasia - Wiley Online Library
-
Reproductive Medicine and Biology | Reproduction Journal - Wiley Online Library
-
Establishing the Cut-Off Values of 17-Hydroxyprogesterone for Diagnosing Congenital Adrenal Hyperplasia: A Prospective Observational Study in a Tertiary Care Hospital - Cureus
-
Secondary Biosynthetic Defects in Women with Late-Onset Congenital Adrenal Hyperplasia - The New England Journal of Medicine
-
Genetic Mapping of the 21-Hydroxylase-Deficiency Gene within the HLA Linkage Group - The New England Journal of Medicine
-
Fertility Rates in Female Patients with Congenital Adrenal Hyperplasia due to 21-Hydroxlyase Deficiency - The New England Journal of Medicine
-
Congenital Hypoaldosteronism: The Visser-Cost Syndrome Revisited - Nature
Why This Topic Is Trending
This topic has recently gained attention due to increased public interest. Search activity and Wikipedia pageviews suggest growing global engagement.
Search Interest & Related Topics
Search interest data over the past 12 months indicates that this topic periodically attracts global attention. Sudden spikes often correlate with major news events, public statements, or geopolitical developments.