Why is "25-hydroxycholecalciferol" trending?
Latest news, Wikipedia summary, and trend analysis.
Trend Analysis
- Ranking position: #
- Date: 2026-05-13 14:40:01
This topic has appeared in the trending rankings 1 time(s) in the past year. While it does not trend frequently, its appearance suggests a renewed or concentrated surge of public interest.
Based on Wikipedia pageviews and search interest, this topic gained significant attention on the selected date.
Trend Insight
25-hydroxycholecalciferol entered the ranking for the first time today at position #. This is its highest position ever recorded.
Trend History
This topic has appeared in the English Wikipedia rankings 1 time. It first appeared on 2026-05-13 and was most recently seen on 2026-05-13.
Wikipedia Overview
Calcifediol, also known as calcidiol, 25-hydroxycholecalciferol, or 25-hydroxyvitamin D3 (abbreviated 25(OH)D3), is a form of vitamin D produced in the liver by hydroxylation of vitamin D3 (cholecalciferol) by the enzyme vitamin D 25-hydroxylase. Calcifediol can be further hydroxylated by the enzyme 25(OH)D-1α-hydroxylase, primarily in the kidney, to form calcitriol (1,25-(OH)2D3), which is the active hormonal form of vitamin D.
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Trending Topic Today
Search Interest Perspective
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metabolism modulates the effect of variable UV exposure on 25-hydroxyvitamin D - Nature
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Plasma 25-hydroxyvitamin D concentrations, vitamin D deficiency and mortality in community-dwelling Japanese adults - Cambridge University Press & Assessment
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Association of 25-hydroxyvitamin D with sex hormones and body composition in Chinese older adults - Frontiers
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25-Hydroxycholecalciferol is most effective in raising serum 25-hydroxyvitamin D - American Society for Nutrition
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Hy-D feed supplement receives EU approval for use in aquaculture - WEAREAQUACULTURE
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Association of 25-hydroxyvitamin D levels and vitamin D receptor gene polymorphisms with breast cancer risk in Bangladeshi women - Nature
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China’s new feed rule spurs warnings - All About Feed
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China vitamin D3 feed standard may redirect non-compliant products to global markets - Food Ingredients First
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The relationship between serum 25-hydroxyvitamin D levels and dyslipidemia risk: insights from a study of elderly Chinese diabetic foot ulcer patients - Frontiers
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25-Hydroxy Vitamin D Test: Purpose, Procedure, and Results - Healthline
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Maternal vitamin D intake correlates with serum 25-Hydroxyvitamin D, Interleukin-6, and ferritin in maternal and umbilical cord | Scientific Reports - Nature
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Analysis of chemiluminescence and liquid chromatography-mass spectrometry in 25-hydroxyvitamin D detection using fuzzy logic - Nature
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Persistent Increase in Serum 25-Hydroxyvitamin D Concentration in a Dog Following Cholecalciferol Intoxication - Frontiers
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Effect of freezing and storage on serum vitamin D levels measured by mass spectrometry and immunoassay in reproductive age women - Nature
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Genome-wide association study identifies 143 loci associated with 25 hydroxyvitamin D concentration - Nature
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Relationship of serum 25-hydroxyvitamin D, obesity with new-onset obstructive sleep apnea - Nature
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Genetic correlates of vitamin D-binding protein and 25-hydroxyvitamin D in neonatal dried blood spots - Nature
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25-Hydroxyvitamin D reference percentiles and the role of their determinants among European children and adolescents - Nature
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The relationship between serum 25-hydroxyvitamin D levels and the severity of COVID-19 disease and its mortality - Nature
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Seasonal variability of serum 25-hydroxyvitamin D on multiple sclerosis onset - Nature
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Causal effect of the 25-Hydroxyvitamin D concentration on ocular diseases: A Mendelian randomization study - Nature
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The association between serum 25-hydroxyvitamin D levels and erectile dysfunction: a two-sample Mendelian randomization analysis - Nature
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Association of 25-hydroxyvitamin D with Parkinson’s disease based on the results from the NHANES 2007 to 2018 and Mendelian randomization analysis - Nature
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Nonlinear association between serum 25-hydroxyvitamin D concentrations and lung function in the United States adult population with COPD - Nature
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Association between serum 25-hydroxyvitamin D and fasting blood glucose in osteoporosis patients - Nature
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Clinical characteristics and serum 25-hydroxyvitamin D levels in children with febrile seizures in China - Nature
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Circulating 25-hydroxyvitamin D and survival outcomes of colorectal cancer: evidence from population-based prospective cohorts and Mendelian randomisation - Nature
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Association between circulating 25-hydroxyvitamin D and cardiometabolic risk factors in adults in rural and urban settings - Nature
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Spatial distribution differences of 25-hydroxyvitamin D in healthy elderly people under the influence of geographical environmental factors - Nature
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Correlation and consistency between two detection methods for serum 25 hydroxyvitamin D levels in human venous blood and capillary blood - Frontiers
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Predictors of 25-hydroxyvitamin D concentrations during pregnancy: A longitudinal analysis in the Brazilian Amazon - Nature
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US recommendations fail to correct vitamin D deficiency - Nature
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Serum Bioavailable and Free 25-Hydroxyvitamin D Levels, but Not Its Total Level, Are Associated With the Risk of Mortality in Patients With Coronary Artery Disease | Circulation Research - American Heart Association Journals
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Social determinants of serum 25-hydroxyvitamin D concentrations deficiency in older Chilean people - Nature
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Association of 25-hydroxyvitamin D with risk of overall and colorectal cancer among Japanese using a Mendelian randomization approach - Nature
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Relationship between serum 25 hydroxyvitamin D (25(OH)D) levels and mental health in shift female nurses - Nature
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Reduced 25-hydroxyvitamin D concentration in the aqueous humor of cataract patients with open-angle glaucoma - Nature
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Decreased preoperative serum 25-Hydroxyvitamin D levels in colorectal cancer are associated with systemic inflammation and serrated morphology - Nature
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Association of maternal serum 25-hydroxyvitamin D concentrations in second and third trimester with risk of macrosomia - Nature
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CYP2R1 is a major, but not exclusive, contributor to 25-hydroxyvitamin D production in vivo - PNAS
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Relationship between Sleep Duration, Sun Exposure, and Serum 25-Hydroxyvitamin D Status: A Cross-sectional Study - Nature
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Inverse Relationship between Metabolic Syndrome and 25-Hydroxyvitamin D Concentration in Elderly People without Vitamin D deficiency - Nature
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The impact of vitamin D pathway genetic variation and circulating 25-hydroxyvitamin D on cancer outcome: systematic review and meta-analysis - Nature
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Rapid Analysis of C3 Epimers of 25-Hydroxyvitamin D in Serum by LC–MS/MS - Chromatography Online
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Serum 25-hydroxyvitamin D level is associated with short-term glycemic variability metrics derived from continuous glucose monitoring in T2DM - Nature
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Cholecalciferol-fortified skim milk increased total and free 25-hydroxyvitamin D in Columbian adolescents and women - American Society for Nutrition
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Genome-wide association study in 79,366 European-ancestry individuals informs the genetic architecture of 25-hydroxyvitamin D levels - Nature
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Relationship between serum 25-hydroxyvitamin D and target organ damage in children with essential hypertension - Nature
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C3-epi-25(OH)D3 percentage, not level, may be a potential biomarker to reflect its pathological increase in multiple diseases: a cross-sectional case–control study - Nature
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Utility of umbilical cord blood 25-hydroxyvitamin D levels for predicting bronchopulmonary dysplasia in preterm infants with very low and extremely low birth weight - Frontiers
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Cord Blood 25-hydroxyvitamin D and Fetal Growth in the China-Anhui Birth Cohort Study | Scientific Reports - Nature
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Associations between serum 25-hydroxyvitamin D and bone turnover markers in a population based sample of German children - Nature
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Effect of obesity on the associations of 25-hydroxyvitamin D with prevalent and incident distal sensorimotor polyneuropathy: population-based KORA F4/FF4 study - Nature
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Vitamin D: a critical and essential micronutrient for human health - Frontiers
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The metabolism of 1,25(OH)2D3 in clinical and experimental kidney disease | Scientific Reports - Nature
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High prevalence of low vitamin D status in the Czech Republic: a retrospective study of 119,925 participants - Nature
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25-Hydroxyvitamin D3 induces osteogenic differentiation of human mesenchymal stem cells | Scientific Reports - Nature
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Association between vitamin D supplementation and COVID-19 infection and mortality | Scientific Reports - Nature
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IgG index and not serum 25-hydroxyvitamin D is associated with age at onset of multiple sclerosis - medRxiv
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Sex and body mass index dependent associations between serum 25-hydroxyvitamin D and pulse pressure in middle-aged and older US adults - Nature
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Cosinor modelling of seasonal variation in 25-hydroxyvitamin D concentrations in cardiovascular patients in Norway - Nature
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Parameters of Bone and Cardiovascular Health Related to 25-Hydroxyvitamin D Status in Emirati Nationals attending Primary Care and Diabetes services: a retrospective cohort study - Nature
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Determination of the fate of Cholecalciferol injected by the basis of 25D3 plasma concentration - Nature
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Vitamin D in plants: a review of occurrence, analysis, and biosynthesis - Frontiers
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Natural Vitamin D in Food: To What Degree Does 25-Hydroxyvitamin D Contribute to the Vitamin D Activity in Food? - Wiley Online Library
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Exploring vitamin D metabolism and function in cancer - Nature
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25-Hydroxyvitamin D, APOE ɛ4 genotype and cognitive function: findings from the 1958 British birth cohort - Nature
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Graphene oxide and fluorescent aptamer based novel biosensor for detection of 25-hydroxyvitamin D - Nature
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The Role of Vitamin D Binding Protein, Total and Free 25-Hydroxyvitamin D in Diabetes - Frontiers
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Causal effect of serum 25-hydroxyvitamin D levels on low back pain: A two-sample mendelian randomization study - Frontiers
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shows markedly elevated levels in early life, particularly from vitamin D supplementation in preterm infants - Nature
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Role of Vitamin D Supplementation in Heart Failure Patients With Vitamin D Deficiency and Its Effects on Clinical Outcomes: A Literature Review - Cureus
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Relationship between serum 25-hydroxyvitamin D and parathyroid hormone in the search for a biochemical definition of vitamin D deficiency in children - Nature
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Associations between 25-hydroxyvitamin D levels and pregnancy outcomes: a prospective observational study in southern China - Nature
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The dynamic relationships between the active and catabolic vitamin D metabolites, their ratios, and associations with PTH - Nature
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UVB-emitting cloth to prevent low serum 25-hydroxyvitamin D caused by clothing - Nature
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Winter 25-hydroxyvitamin D levels in young urban adults are affected by smoking, body mass index and educational level - Nature
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Seasonal variation of idiopathic benign paroxysmal positional vertigo correlates with serum 25-hydroxyvitamin D levels: a six-year registry study in Shanghai, China | Scientific Reports - Nature
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Low serum 25-hydroxyvitamin D levels are associated with liver injury markers in the US adult population - Cambridge University Press & Assessment
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Is there a relationship between 25-hydroxyvitamin D (25[OH]D) levels and anthropometry in patients with epilepsy? - SciELO España
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Vitamin D intake, blood 25(OH)D levels, and breast cancer risk or mortality: a meta-analysis | British Journal of Cancer - Nature
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25-Hydroxyvitamin D2/D3 Analysis in Human Plasma Using LC–MS - Chromatography Online
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The Non-conventional Effects of Hypovitaminosis D: A Pandemic Even in Sunlight-Rich Countries - Cureus
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Circulating 25-hydroxyvitamin D levels and hypertension risk after adjusting for publication bias. - Physician's Weekly
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Analysis of UV-Treated Mushrooms: Dietary Source of Vitamin D2? - Chromatography Online
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Redefining Human Vitamin D Sufficiency: Back to the Basics - Nature
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25-Hydroxyvitamin D and cognitive performance in mid-life - Cambridge University Press & Assessment
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The association between low 25-hydroxyvitamin D and increased aortic stiffness - Nature
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Single bout of exercise triggers the increase of vitamin D blood concentration in adolescent trained boys: a pilot study - Nature
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Effect of adipose tissue volume loss on circulating 25-hydroxyvitamin D levels: results from a 1-year lifestyle intervention in viscerally obese men - Nature
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Association of 25‐hydroxyvitamin D status with brain volume changes - Lee - 2021 - Food Science & Nutrition - Wiley Online Library
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New insights into the vitamin D requirements during pregnancy - Nature
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Decreased serum levels of 25-OH vitamin D and vitamin K in patients with type 2 diabetes mellitus - Frontiers
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The correlation between serum 25-hydroxy-vitamin D levels and anti-SARS-CoV-2 S-RBD IgG and neutralizing antibody levels among cancer patients receiving COVID-19 vaccines - Frontiers
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Yeast as a biological platform for vitamin D production: A promising alternative to help reduce vitamin D deficiency in humans - Wiley Online Library
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Higher Levels of Vitamin D Correspond to Lower Cancer Risk, Researchers Say - UC San Diego Today
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Serum 25-Hydroxyvitamin D Concentrations and Risk for Hip Fractures - ACP Journals
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25(OH)D Concentration in Neonates, Infants, and Toddlers From Poland—Evaluation of Trends During Years 1981–2011 - Frontiers
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Vitamin D binding protein is required to utilize skin-generated vitamin D - PNAS
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Vitamin D Status and Mortality - Endocrine Society
Why This Topic Is Trending
This topic has recently gained attention due to increased public interest. Search activity and Wikipedia pageviews suggest growing global engagement.
Search Interest & Related Topics
Search interest data over the past 12 months indicates that this topic periodically attracts global attention. Sudden spikes often correlate with major news events, public statements, or geopolitical developments.