Why is "3′ UTR" trending?

Search Interest Perspective

• VaxLab: integrated platform for rapid multistrategy mRNA vaccine design - Nature
• 3′UTR Mapping Reveals Alternative Polyadenylation in Right Ventricular Failure - American Heart Association Journals
• Incorporation of a Human-Derived CU-Rich Element in the 3′ UTR Improves Synthetic mRNA Stability and Expression In Vivo - ACS Publications
• 3′UTR Mapping Reveals Alternative Polyadenylation in Right Ventricular Failure - American Heart Association Journals
• Origin and adaptive evolutionary trajectory of the 3′ UTR–derived sRNA UhpU in Enterobacteriaceae - PNAS
• 3′UTR-derived small RNA couples acid resistance to metabolic reprogramming in Salmonella within macrophages - Phys.org
• A common DNA deletion altering the 3’UTR of mdr1 is associated with reduced mefloquine susceptibility in P. vivax parasites from Cambodian patients - Nature
• Structural insights into the role of eIF3 in translation mediated by the HCV IRES - PNAS
• Identification of mathematical patterns in genomic spectrograms linked to variant classification in complete SARS-CoV-2 sequences - Nature
• The SYNGAP1 3′UTR Variant in ALS Patients Causes Aberrant SYNGAP1 Splicing and Dendritic Spine Loss by Recruiting HNRNPK - Journal of Neuroscience
• U-rich elements drive pervasive cryptic splicing in 3’ UTR massively parallel reporter assays - Nature
• Altered polyadenylation site usage in SERPINA1 3’UTR in response to cellular stress affects A1AT protein expression - Nature
• The role of untranslated region variants in Mendelian disease: a review | European Journal of Human Genetics - Nature
• Genome-wide analysis of 3′ untranslated region alternative polyadenylation quantitative trait loci identified a potential novel susceptibility locus for lung cancer in cross-ancestry populations - Nature
• 3′ UTR shortening represses tumor-suppressor genes in trans by disrupting ceRNA crosstalk - Nature
• mRNA 3’UTR lengthening by alternative polyadenylation attenuates inflammatory responses and correlates with virulence of Influenza A virus - Nature
• Immune-response 3′UTR alternative polyadenylation quantitative trait loci contribute to variation in human complex traits and diseases - Nature
• Quantifying 3′UTR length from scRNA-seq data reveals changes independent of gene expression - Nature
• mRNA 3′-UTR shortening is a molecular signature of mTORC1 activation - Nature
• Experimental capture of miRNA targetomes: disease-specific 3′UTR library-based miRNA targetomics for Parkinson’s disease | Experimental & Molecular Medicine - Nature
• A curated census of pathogenic and likely pathogenic UTR variants and evaluation of deep learning models for variant effect prediction - Frontiers
• Enhancers regulate 3′ end processing activity to control expression of alternative 3′UTR isoforms - Nature
• Pan-cancer pervasive upregulation of 3′ UTR splicing drives tumourigenesis - Nature
• Alternative polyadenylation alters protein dosage by switching between intronic and 3′UTR sites - Science | AAAS
• CRISPR knock-in of a chimeric antigen receptor into GAPDH 3’UTR locus generates potent B7H3-specific NK-92MI cells | Cancer Gene Therapy - Nature
• Alternative 3′UTR expression induced by T cell activation is regulated in a temporal and signal dependent manner - Nature
• Massively parallel screen uncovers many rare 3′ UTR variants regulating mRNA abundance of cancer driver genes - Nature
• In vivo RNA interactome profiling reveals 3’UTR-processed small RNA targeting a central regulatory hub - Nature
• Cumulative effects of weakly repressive regulatory regions in the 3’ UTR maintain PD-1 expression homeostasis in mammals - Nature
• Cellular stress alters 3′UTR landscape through alternative polyadenylation and isoform-specific degradation - Nature
• Live cell imaging reveals 3′-UTR dependent mRNA sorting to synapses - Nature
• Post-transcriptional 3´-UTR cleavage of mRNA transcripts generates thousands of stable uncapped autonomous RNA fragments - Nature
• Shifting the spotlight away from coding regions uncovers that 3’UTR mutations may contribute to cellular oncogenicity and poor patient prognosis in advanced stage prostate cancer - Fred Hutchinson Cancer Center
• Optimization of the 5ʹ untranslated region of mRNA vaccines - Nature
• Effective inhibition of dengue virus replication using 3′UTR-targeted Vivo-Morpholinos - Frontiers
• Bacterial 3′UTRs: A Useful Resource in Post-transcriptional Regulation - Frontiers
• Misfolded human tRNA isodecoder binds and neutralizes a 3′ UTR-embedded Alu element - PNAS
• Fusing the 3’UTR of seed storage protein genes leads to massive recombinant protein accumulation in seeds - Nature
• Whole-genome sequencing reveals that variants in the Interleukin 18 Receptor Accessory Protein 3′UTR protect against ALS - Nature
• Roquin targets mRNAs in a 3′-UTR-specific manner by different modes of regulation - Nature
• RNase III-CLASH of multi-drug resistant Staphylococcus aureus reveals a regulatory mRNA 3′UTR required for intermediate vancomycin resistance - Nature
• Tuning of mRNA stability through altering 3′-UTR sequences generates distinct output expression in a synthetic circuit driven by p53 oscillations - Nature
• Genetic 3′UTR variations and clinical factors significantly contribute to survival prediction and clinical response in breast cancer patients - Nature
• Pervasive 3′-UTR Isoform Switches During Mouse Oocyte Maturation - Frontiers
• Global 3′ UTR shortening has a limited effect on protein abundance in proliferating T cells - Nature
• A specific domain within the 3′ untranslated region of Usutu virus confers resistance to the exonuclease ISG20 - Nature
• An RNA-binding regulatory cascade controls the switch from proliferation to differentiation in the Drosophila male germ cell lineage - PNAS
• Autonomous action and cooperativity between the ONECUT2 transcription factor and its 3′ untranslated region - Frontiers
• Massively parallel identification of mRNA localization elements in primary cortical neurons - Nature
• Conserved 3′ UTR of Severe Acute Respiratory Syndrome Coronavirus 2: Potential Therapeutic Targets - Frontiers
• Quantifying negative selection in human 3ʹ UTRs uncovers constrained targets of RNA-binding proteins - Nature
• A Viral mRNA Motif at the 3′-Untranslated Region that Confers Translatability in a Cell-Specific Manner. Implications for Virus Evolution - Nature
• 3'UTR of tobacco vein mottling virus regulates downstream GFP expression and changes in host gene expression - Frontiers
• 3′-UTR engineering to improve soluble expression and fine-tuning of activity of cascade enzymes in Escherichia coli - Nature
• The thymocyte-specific RNA-binding protein Arpp21 provides TCR repertoire diversity by binding to the 3 -UTR and promoting Rag1 mRNA expression - Nature
• Distinct 3′UTRs differentially regulate activity-dependent translation of brain-derived neurotrophic factor (BDNF) - PNAS
• Non-invasive plasma testing for CD274 UTR structural variations by next-generation sequencing in cancer - Nature
• ADAR1-mediated 3′ UTR editing and expression control of antiapoptosis genes fine-tunes cellular apoptosis response - Nature
• Leveraging multi-omics data to infer regulators of mRNA 3’ end processing in glioblastoma - Frontiers
• Arc 3′ UTR Splicing Leads to Dual and Antagonistic Effects in Fine-Tuning Arc Expression Upon BDNF Signaling - Frontiers
• Post-transcriptional reprogramming by thousands of mRNA untranslated regions in trypanosomes - Nature
• A TBX5 3′UTR variant increases the risk of congenital heart disease in the Han Chinese population | Cell Discovery - Nature
• ALKBH5-dependent m6A demethylation controls splicing and stability of long 3′-UTR mRNAs in male germ cells - PNAS
• 3′UTR shortening identifies high-risk cancers with targeted dysregulation of the ceRNA network - Nature
• Dynamic analyses of alternative polyadenylation from RNA-seq reveal a 3′-UTR landscape across seven tumour types - Nature
• The Length of the Expressed 3′ UTR Is an Intermediate Molecular Phenotype Linking Genetic Variants to Complex Diseases - Frontiers
• Altered RNA editing in 3′ UTR perturbs microRNA-mediated regulation of oncogenes and tumor-suppressors - Nature
• Long 3′UTRs predispose neurons to inflammation by promoting immunostimulatory double-stranded RNA formation - Science | AAAS
• Roquin recognizes a non-canonical hexaloop structure in the 3′-UTR of Ox40 - Nature
• UTR Therapeutics Inc Announces IND submission to the US FDA - GlobeNewswire
• Staphylococcus aureus ftnA 3’-Untranslated Region Modulates Ferritin Production Facilitating Growth Under Iron Starvation Conditions - Frontiers
• 3′-end mRNA processing within apicomplexan parasites, a patchwork of classic, and unexpected players - Wiley Interdisciplinary Reviews
• Mutation in the 3’untranslated region of APP as a genetic determinant of cerebral amyloid angiopathy - Nature
• Integrative analysis reveals RNA G-quadruplexes in UTRs are selectively constrained and enriched for functional associations - Nature
• miR-526b targets 3′ UTR of MMP1 mRNA - Nature
• Ribosome-induced RNA conformational changes in a viral 3′-UTR sense and regulate translation levels - Nature
• A Novel SARS-CoV-2 Viral Sequence Bioinformatic Pipeline Has Found Genetic Evidence That the Viral 3′ Untranslated Region (UTR) Is Evolving and Generating Increased Viral Diversity - Frontiers
• HLA-G 3′ untranslated region variants +3187G/G, +3196G/G and +3035T define diametrical clinical status and disease outcome in epithelial ovarian cancer - Nature
• Structural analysis of 3’UTRs in insect flaviviruses reveals novel determinants of sfRNA biogenesis and provides new insights into flavivirus evolution - Nature
• Aberrant PD-L1 expression through 3′-UTR disruption in multiple cancers - Nature
• G-quadruplex structures within the 3′ UTR of LINE-1 elements stimulate retrotransposition - Nature
• The 5′ and 3′ Untranslated Regions of the Japanese Encephalitis Virus (JEV): Molecular Genetics and Higher Order Structures - Frontiers
• Context-specific regulation and function of mRNA alternative polyadenylation - Nature
• AU-Rich Long 3′ Untranslated Region Regulates Gene Expression in Bacteria - Frontiers
• MicroRNA-421 confers paclitaxel resistance by binding to the KEAP1 3′UTR and predicts poor survival in non-small cell lung cancer - Nature
• A gain-of-function ACTC1 3′UTR mutation that introduces a miR-139-5p target site may be associated with a dominant familial atrial septal defect - Nature
• Leveraging omic features with F3UTER enables identification of unannotated 3’UTRs for synaptic genes - Nature
• Development of the urogenital system is regulated via the 3′UTR of GDNF - Nature
• Phylogenetic analysis of the 5ʹ untranslated region of HCV from cirrhotic patients in Khyber Pakhtunkhwa, Pakistan - Nature
• The 3’UTRs of Myelin Basic Protein mRNAs Regulate Transport, Local Translation and Sensitivity to Neuronal Activity in Zebrafish - Frontiers
• The tRNA methyltransferase NSun2 stabilizes p16 - Nature
• Crosstalk Between mRNA 3'-End Processing and Epigenetics - Frontiers
• Features of CFTR mRNA and implications for therapeutics development - Frontiers
• A 3′UTR modification of the TNF-α mouse gene increases peripheral TNF-α and modulates the Alzheimer-like phenotype in 5XFAD mice - Nature
• TMV mutants with poly(A) tracts of different lengths demonstrate structural variations in 3′UTR affecting viral RNAs accumulation and symptom expression - Nature
• Human cellular CYBA UTR sequences increase mRNA translation without affecting the half-life of recombinant RNA transcripts - Nature
• Effects of microRNA-298 on APP and BACE1 translation differ according to cell type and 3′-UTR variation - Nature
• RNA Structure Duplication in the Dengue Virus 3′ UTR: Redundancy or Host Specificity? - ASM Journals
• Hes7 3′UTR is required for somite segmentation function - Nature
• A prevalent cancer susceptibility APOBEC3A hybrid allele bearing APOBEC3B 3′UTR enhances chromosomal DNA damage - Nature