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Why is "3-hydroxy-3-methylglutaryl-CoA lyase deficiency" trending?

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Trend Analysis

  • Ranking position: #
  • Date: 2026-03-16 21:10:41

This topic has appeared in the trending rankings 1 time(s) in the past year. While it does not trend frequently, its appearance suggests a renewed or concentrated surge of public interest.

Based on Wikipedia pageviews and search interest, this topic gained significant attention on the selected date.

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3-hydroxy-3-methylglutaryl-CoA lyase deficiency

Wikipedia Overview

3-Hydroxy-3-methylglutaryl-CoA lyase deficiency, (HMGCLD) also known as HMGCL deficiency, HMG-CoA lyase deficiency, or hydroxymethylglutaric aciduria, is an uncommon autosomal recessive inborn error in ketone body production and leucine breakdown caused by HMGCL gene mutations. HMGCL, located on chromosome 1p36.11's short arm, codes for HMG-CoA lyase, which aids in the metabolism of dietary proteins by converting HMG-CoA into acetyl-CoA and acetoacetate.

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This topic has recently gained attention due to increased public interest. Search activity and Wikipedia pageviews suggest growing global engagement.


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Search interest data over the past 12 months indicates that this topic periodically attracts global attention. Sudden spikes often correlate with major news events, public statements, or geopolitical developments.

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