Why is "4-Hydroxycoumarins" trending?
Latest news, Wikipedia summary, and trend analysis.
Trend Analysis
- Ranking position: #
- Date: 2026-03-25 10:51:50
This topic has appeared in the trending rankings 1 time(s) in the past year. While it does not trend frequently, its appearance suggests a renewed or concentrated surge of public interest.
Based on Wikipedia pageviews and search interest, this topic gained significant attention on the selected date.
Trend Insight
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Wikipedia Overview
4-Hydroxycoumarins are a class of vitamin K antagonist (VKA) anticoagulant drug molecules. Chemically, they are derived from coumarin by adding a hydroxy group at the 4 position to obtain 4-hydroxycoumarin, then adding a large aromatic substituent at the 3-position. The large 3-position substituent is required for anticoagulant activity.
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Trending Topic Today
Search Interest Perspective
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Chlorinated bis-4-hydroxycoumarins suppress flavivirus replication by inhibiting dengue virus type 2 translation and replication - Nature
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A Bifunctional Organic Photocatalyst for Efficient Single-Electron and Energy Transfer Activation - Wiley Online Library
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Synthesis, biological evaluation, and molecular docking of novel coumarin-based bisimine derivatives - Nature
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Application of a New Established System for Toxic Doses in Children With 4-Hydroxycoumarin Rodenticide Intoxication - Frontiers
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Divergent Photosensitizer Controlled Reactions of 4‐Hydroxycoumarins and Unactivated Olefins: Hydroarylation and Subsequent [2+2] Cycloaddition - Chang - 2023 - Angewandte Chemie International Edition - Wiley Online Library
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Structural tuning of β-enamino diketones: exploration of solution and crystalline state photochromism - Frontiers
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Crystal structure determination from powder diffraction data of the coumarin vanillin chalcone - cambridge.org
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Design of new α-glucosidase inhibitors based on the bis-4-hydroxycoumarin skeleton: Synthesis, evaluation, and in silico studies - Nature
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Copper(I) Bromide-Dimethyl Sulfide-Catalyzed Direct Sulfanylation of 4-Hydroxycoumarins and 4-Hydroxyquinolinones with Arylsulfonylhydrazides and Selective Fluorescence Switch- On Sensing of Cadmium(II) Ion in Water - Wiley
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A comprehensive review on the potential of coumarin and related derivatives as multi-target therapeutic agents in the management of gynecological cancers - Frontiers
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Synthesis of coumarin derivatives and investigation of their inhibitory effects on lung cancer cell motility - Nature
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Benzenediazonium Tetrafluoroborate-Catalyzed Formal [3 + 3] Cyclization of 4-Hydroxycoumarins With Propargylicalcohols - Wiley Online Library
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Coumarin derivatives from Ainsliaea fragrans and their anticoagulant activity | Scientific Reports - Nature
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Novel macromolecules derived from coumarin: synthesis and antioxidant activity | Scientific Reports - Nature
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Development of novel ferrocene-based MNP and its catalytic activity investigation in the synthesis of 3-amino benzyl-4-hydroxycoumarin derivatives - Wiley Online Library
Why This Topic Is Trending
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Search Interest & Related Topics
Search interest data over the past 12 months indicates that this topic periodically attracts global attention. Sudden spikes often correlate with major news events, public statements, or geopolitical developments.