Why is "4-Methoxyestradiol" trending?
Latest news, Wikipedia summary, and trend analysis.
Trend Analysis
- Ranking position: #
- Date: 2026-03-30 13:58:54
This topic has appeared in the trending rankings 1 time(s) in the past year. While it does not trend frequently, its appearance suggests a renewed or concentrated surge of public interest.
Based on Wikipedia pageviews and search interest, this topic gained significant attention on the selected date.
Trend Insight
This topic is not currently in the ranking.
Wikipedia Overview
4-Methoxyestradiol (4-ME2) is an endogenous, naturally occurring methoxylated catechol estrogen and metabolite of estradiol that is formed by catechol O-methyltransferase via the intermediate 4-hydroxyestradiol. It has estrogenic activity similarly to estrone and 4-hydroxyestrone.
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Trending Topic Today
Search Interest Perspective
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Central Interaction of 2-Methoxyestradiol and Lipoxygenase in AngII-Hypertension - American Heart Association Journals
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Urinary estrogen metabolites and gastric cancer risk among postmenopausal women - Wiley Online Library
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2-Methoxyestradiol Protects Against Lung Ischemia/Reperfusion Injury by Upregulating Annexin A1 Protein Expression - Frontiers
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Dynamic change of estrogen and progesterone metabolites in human urine during pregnancy - Nature
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Protection of HT22 neuronal cells against chemically-induced ferroptosis by catechol estrogens: protein disulfide isomerase as a mechanistic target - Nature
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Importance of Estrogen Metabolites - American Heart Association Journals
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Sex Differences, Estrogen Metabolism and Signaling in the Development of Pulmonary Arterial Hypertension - Frontiers
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CYP3A7*1C allele is associated with reduced levels of 2-hydroxylation pathway oestrogen metabolites - Nature
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Sex Differences in Pulmonary Hypertension - Frontiers
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Estradiol-17β and Its Cytochrome P450- and Catechol- O -Methyltransferase–Derived Metabolites Stimulate Proliferation in Uterine Artery Endothelial Cells: - American Heart Association Journals
Why This Topic Is Trending
This topic has recently gained attention due to increased public interest. Search activity and Wikipedia pageviews suggest growing global engagement.
Search Interest & Related Topics
Search interest data over the past 12 months indicates that this topic periodically attracts global attention. Sudden spikes often correlate with major news events, public statements, or geopolitical developments.