Why is "4-hydroxybutyrate" trending?
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- Date: 2026-04-05 13:33:59
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Wikipedia Overview
γ-Hydroxybutyric acid, also known as gamma-hydroxybutyric acid, GHB, or 4-hydroxybutanoic acid, is a naturally occurring neurotransmitter and a depressant drug. It is a precursor to GABA, glutamate, and glycine in certain brain areas. It acts on the GHB receptor and is a weak agonist at the GABAB receptor. GHB has been used in medicine as a general anesthetic and as treatment for cataplexy, narcolepsy, and alcoholism. It is also used illicitly for performance enhancement, date rape, and recreation.
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Search Interest Perspective
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Development of Photobacterium sp. LN01 as a Versatile Halophilic Platform for Tunable Biosynthesis of Polyhydroxyalkanoates - ACS Publications
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Journal of Applied Polymer Science - Wiley Online Library
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Production of poly(3-hydroxybutyrate) by Rhodococcus qingshengii N9T-4 using the oligotrophic gene expression system | Scientific Reports - Nature
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Poly(4-Hydroxybutyrate): Current State and Perspectives - Frontiers
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A dicarboxylate/4-hydroxybutyrate autotrophic carbon assimilation cycle in the hyperthermophilic Archaeum Ignicoccus hospitalis - PNAS
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A 3-Hydroxypropionate/4-Hydroxybutyrate Autotrophic Carbon Dioxide Assimilation Pathway in Archaea - Science | AAAS
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Polyhydroxybutyrate (PHB) Market Size, Share | CAGR of 16.6% - Market.us
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Gamma-hydroxybutyrate to promote slow-wave sleep in major depressive disorder: a randomized crossover trial - Nature
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d -β-Hydroxybutyrate protects neurons in models of Alzheimer's and Parkinson's disease - PNAS
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Succinic semialdehyde dehydrogenase deficiency: a metabolic and genomic approach to diagnosis - Frontiers
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Crystal structure of the 4-hydroxybutyryl-CoA synthetase (ADP-forming) from nitrosopumilus maritimus - Nature
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A Review on Enhancing Cupriavidus necator Fermentation for Poly(3-hydroxybutyrate) (PHB) Production From Low-Cost Carbon Sources - Frontiers
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Structural insights into bifunctional thaumarchaeal crotonyl-CoA hydratase and 3-hydroxypropionyl-CoA dehydratase from Nitrosopumilus maritimus - Nature
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Suppression by γ-Hydroxybutyric Acid of “Alcohol Deprivation Effect” in Rats: Preclinical Evidence of its anti-Relapse Properties - Frontiers
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β-Hydroxybutyrate suppresses M1 macrophage polarization through β-hydroxybutyrylation of the STAT1 protein - Nature
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Optimization for the efficient recovery of poly(3-hydroxybutyrate) using the green solvent 1,3-dioxolane - Frontiers
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Construction of a synthetic metabolic pathway for biosynthesis of 2,4-dihydroxybutyric acid from ethylene glycol - Nature
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Adipocytes promote malignant growth of breast tumours with monocarboxylate transporter 2 expression via β-hydroxybutyrate - Nature
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Coastal and deep-sea biodegradation of polyhydroxyalkanoate microbeads - Nature
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Chemical synthesis of perfectly isotactic and high melting bacterial poly(3-hydroxybutyrate) from bio-sourced racemic cyclic diolide - Nature
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The effect of natural fillers on the marine biodegradation behaviour of poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) - Nature
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Biodegradation of polyhydroxyalkanoates: current state and future prospects - Frontiers
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α4βδ GABAA receptors are high-affinity targets for γ-hydroxybutyric acid (GHB) - PNAS
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Five ways to cycle carbon - Nature
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Targeted quantitative profiling of metabolites and gene transcripts associated with 4-aminobutyrate (GABA) in apple fruit stored under multiple abiotic stresses | Horticulture Research - Nature
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Repurposing of substances with lactone moiety for the treatment of γ-Hydroxybutyric acid and γ-Butyrolactone intoxication through modulating paraoxonase and PPARγ - Frontiers
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Gamma-Hydroxybutyrate Increases Resting-State Limbic Perfusion and Body and Emotion Awareness in Humans - Nature
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Gamma-hydroxybutyric acid-induced organic delirium complicated by polydrug use successfully treated with electroconvulsive therapy: a case report - Springer Nature Link
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A review on poly(3-hydroxybutyrate-co-3-hydroxyhexanoate) [P(3HB-co-3HHx)] and genetic modifications that affect its production - Frontiers
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Urinary concentrations of GHB and its novel amino acid and carnitine conjugates following controlled GHB administration to humans - Nature
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Emergency Medicine Australasia | ACEM Journal - Wiley Online Library
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Extrasynaptic site of action for γ-hydroxybutyrate - PNAS
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Relative Abuse Liability of GHB in Humans: A Comparison of Psychomotor, Subjective, and Cognitive Effects of Supratherapeutic Doses of Triazolam, Pentobarbital, and GHB - Nature
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-mediated Inhibitory Postsynaptic Potentials in the CA1 Region of Hippocampus - Nature
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Synergistic interactions between “club drugs”: gamma-hydroxybutyrate and N-methyl-d-aspartate antagonists. - Wiley
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GHB and harm reduction - Alcohol and Drug Foundation
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A nail polish to detect drugs? - McGill University
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Gamma-Hydroxybutyrate and Cocaine Administration Increases mRNA Expression of Dopamine D - Nature
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Parcel containing 17.75L of GHB was largest quantity Weyburn police have seen - 980 CJME
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