Why is "5-HT2A" trending?
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- Date: 2026-04-05 16:09:50
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Wikipedia Overview
The 5-HT2A receptor is a subtype of the 5-HT2 receptor that belongs to the serotonin receptor family and functions as a G protein-coupled receptor (GPCR). It is a cell surface receptor that activates multiple intracellular signalling cascades.
Like all 5-HT2 receptors, the 5-HT2A receptor is coupled to the Gq/G11 signaling pathway. It is the primary excitatory receptor subtype among the serotonin-responsive GPCRs. The 5-HT2A receptor was initially noted for its central role as the primary target of serotonergic psychedelic drugs such as LSD and psilocybin mushrooms. It later regained research prominence when found to mediate, at least in part, the effects of many antipsychotic drugs, particularly atypical antipsychotics.
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Psychedelics elicit their effects by 5-HT2A receptor-mediated Gi signalling - Nature
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Psychedelic 5-HT2A agonist increases spontaneous and evoked 5-Hz oscillations in visual and retrosplenial cortex - Nature
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Investigating 5-HT2A receptor agonists with psychedelic-like activity in preclinical models - News-Medical
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NIDA boost for Atai’s 5-HT2A/2C receptor agonists - BioWorld MedTech
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Psychedelics and the quantum brain: a falsifiable hypothesis on Posner molecules and spin-dependent pharmacology - frontiersin.org
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Study links psilocybin receptor activation to sustained structural brain changes - PsyPost
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Beyond the 5-HT2A Receptor: Classic and Nonclassic Targets in Psychedelic Drug Action - jneurosci.org
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Enveric Biosciences reports EB-003 receptor engagement assay data - Yahoo Finance
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Psilocybin as Transformative Fast-Acting Antidepressant: Pharmacological Properties and Molecular Mechanisms - Wiley Online Library
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Psychedelics promote neuroplasticity through the activation of intracellular 5-HT2A receptors - Science | AAAS
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receptor agonism alters neurovascular coupling and differentially affects neuronal and hemodynamic measures of brain function - Nature
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How 5-HT2A and 5-HT2B receptor reserves shape agonist pharmacology and implications for preclinical safety testing - News-Medical
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receptors in depression and suicide: a systematic review and meta-analysis of in vivo and post-mortem imaging studies - Nature
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layer V medial prefrontal cortex neurons through 5-HT - Nature
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receptor in psilocybin-induced extinction of opioid reward - Nature
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The psychedelic phenethylamine 25C-NBF, a selective 5-HT2A agonist, shows psychoplastogenic properties and rapid antidepressant effects in male rodents | Molecular Psychiatry - Nature
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Binding pose depth modulates photoswitchable ligands’ efficacy at the 5-HT2A receptor | Communications Chemistry - Nature
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receptor in psychedelic-induced neuroplasticity and antidepressant effects - Nature
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Identification of 5-HT2A receptor signaling pathways associated with psychedelic potential | Nature Communications - Nature
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Alzheimer Psychosis Agent ACP-204 Shows No Impact on Corrected QT Intervals in Phase 1 Analysis - NeurologyLive
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Psychedelics activate the 5-HT2A receptor, upregulate brain-derived neurotrophic factor, and enhance synaptic plasticity - EurekAlert!
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Bespoke library docking for 5-HT2A receptor agonists with antidepressant activity - Nature
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receptor regulate psychosis-related effects and memory deficits - Nature
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Psilocybin’s lasting action requires pyramidal cell types and 5-HT2A receptors - Nature
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Pharmacological fingerprint of antipsychotic drugs at the serotonin 5-HT2A receptor | Molecular Psychiatry - Nature
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Gilgamesh touts lasting antidepressive effect with 5-HT2A agonist - FirstWord Pharma
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Role of the 5-HT2A Receptor in Acute Effects of LSD on Empathy and Circulating Oxytocin - frontiersin.org
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New Brain Drugs Mimic Psychedelics Without the Hallucinations - SciTechDaily
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Internalization and recycling of 5-HT2A receptors activated by serotonin and protein kinase C-mediated mechanisms - PNAS
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receptor brain density in subjects with schizophrenia: relevance of radiotracers pharmacological profile - Nature
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Our DNA Could Affect the Potency of Psychedelics in the Brain - Technology Networks
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) receptor affects cell–matrix adhesion and the formation and maintenance of stress fibers in HEK293 cells - Nature
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AbbVie signs to acquire Gilgamesh’s bretisilocin for $1.2bn - Pharmaceutical Technology
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Antidepressant-like effects of psychedelics in a chronic despair mouse model: is the 5-HT - Nature
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Central serotonin-2A (5-HT2A) receptor dysfunction in depression and epilepsy: the missing link? - frontiersin.org
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Molecular, haemodynamic, and functional effects of LSD in the human brain - medRxiv
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Gain control of sensory input across polysynaptic circuitries in mouse visual cortex by a single G protein-coupled receptor type (5-HT - Nature
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Combined oral contraceptive use and serotonin 2A and 2C receptor brain architecture in healthy women - medRxiv
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The role of serotonin 5-HT2A receptors in memory and cognition - frontiersin.org
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Gilgamesh Pharmaceuticals Announces Positive Topline Phase 2a Results for GM-2505 in Major Depressive Disorder (MDD) - PR Newswire
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Effects of a psychedelic 5-HT2A receptor agonist on anxiety-related behavior and fear processing in mice - Nature
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5-HT2A receptor dysregulation in a schizophrenia relevant mouse model of NMDA receptor hypofunction - Nature
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Psilocybin restrains activity-based anorexia in female rats by enhancing cognitive flexibility: contributions from 5-HT1A and 5-HT2A receptor mechanisms | Molecular Psychiatry - Nature
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Molecular design of a therapeutic LSD analogue with reduced hallucinogenic potential - PNAS
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The G protein biased serotonin 5-HT2A receptor agonist lisuride exerts anti-depressant drug-like activities in mice - frontiersin.org
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Psychedelic effects of psilocybin correlate with serotonin 2A receptor occupancy and plasma psilocin levels - Nature
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New Enveric data supports non-hallucinogenic depression and anxiety strategy - Stock Titan
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More Than Serotonin: How Psychedelics Engage the Whole Brain - Neuroscience News
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Variation in Dopamine D2 and Serotonin 5-HT2A Receptor Genes is Associated with Working Memory Processing and Response to Treatment with Antipsychotics - Nature
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Preferential Modulatory Action of 5-HT2A Receptors on the Dynamic Regulation of Basal Ganglia Circuits - jneurosci.org
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The structural diversity of psychedelic drug actions revealed - Nature
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MDMA-Induced Dissociative State not Mediated by the 5-HT2A Receptor - frontiersin.org
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Scientists pinpoint cellular mechanism behind psilocin’s effects on brain activity - PsyPost
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Küleon Bioscience Awarded $2 Million NIAAA Grant to Advance a Novel, Non-Hallucinogenic 5-HT2C Therapeutic Program for Alcohol Use Disorder - Business Wire
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Enhancement of 5-HT2A receptor function and blockade of Kv1.5 by MK801 and ketamine: implications for PCP derivative-induced disease models | Experimental & Molecular Medicine - Nature
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AbbVie To Buy Gilgamesh Pharmaceuticals’ Bretisilocin Therapy - Pulse 2.0
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receptor activity mediates adipocyte differentiation through control of adipogenic gene expression - Nature
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Photoswitchable Serotonins for Optical Control of the 5‐HT2A Receptor** - Wiley Online Library
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Beyond the 5-HT2A Receptor: Classic and Nonclassic Targets in Psychedelic Drug Action - jneurosci.org
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Data-driven analysis of motor activity implicates 5-HT2A neurons in backward locomotion of larval Drosophila - Nature
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Gilgamesh links psychedelic to 94% remission rate in midphase depression trial - Fierce Biotech
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Fully automated head-twitch detection system for the study of 5-HT2A receptor pharmacology in vivo | Scientific Reports - Nature
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Behavioral arrest and a characteristic slow waveform are hallmark responses to selective 5-HT - Nature
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Receptor-informed network control theory links LSD and psilocybin to a flattening of the brain’s control energy landscape - Nature
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antagonist as a clinical candidate for metabolic dysfunction-associated steatohepatitis - Nature
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Htr2a Gene and 5-HT2A Receptor Expression in the Cerebral Cortex Studied Using Genetically Modified Mice - frontiersin.org
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Role of the 5-HT2A Receptor in Self- and Other-Initiated Social Interaction in Lysergic Acid Diethylamide-Induced States: A Pharmacological fMRI Study - jneurosci.org
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Role of the 5-HT2A Receptor in Self- and Other-Initiated Social Interaction in Lysergic Acid Diethylamide-Induced States: A Pharmacological fMRI Study - jneurosci.org
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Blockade of 5-Hydroxytryptamine 2A Receptor Attenuates Precipitation of Naloxone-Induced Withdrawal Symptoms in Opioid-Exposed Mice - frontiersin.org
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Activation of 5-HT2A receptors upregulates the function of the neuronal K-Cl cotransporter KCC2 - PNAS
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Serotonin Modulates Fast-Spiking Interneuron and Synchronous Activity in the Rat Prefrontal Cortex through 5-HT - jneurosci.org
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Transneural Therapeutics: A New Company to Develop Novel Neuroplastogens - Psychiatric Times
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Scientists pinpoint how psychedelic drugs bind to 5-HT2A serotonin receptors. - Psychology Today
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Receptor-Mediated Serotonergic Facilitation of GABA Release in Juvenile Rat Basolateral Amygdala - Nature
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receptor-dependent phosphorylation of mGlu - Nature
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polymorphism and intravaginal ejaculation latency time in Dutch men with lifelong premature ejaculation - Nature
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Receptor-Mediated Serotonergic Enhancement of Synaptic Activity in Rat Medial Prefrontal Cortex - Nature
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Altered 5-HT2A Receptor Binding after Recovery from Bulimia-Type Anorexia Nervosa: Relationships to Harm Avoidance and Drive for Thinness | Neuropsychopharmacology - Nature
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Preferential Modulatory Action of 5-HT2A Receptors on the Dynamic Regulation of Basal Ganglia Circuits - jneurosci.org
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Harnessing psilocybin: antidepressant-like behavioral and synaptic actions of psilocybin are independent of 5-HT2R activation in mice - PNAS
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Serotonin modulates excitatory synapse maturation in the developing prefrontal cortex - Nature
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Small molecule drug screening in Drosophila identifies the 5HT2A receptor as a feeding modulation target - Nature
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Receptors in the Nucleus Accumbens on Inhibitory Response Control in the 5-Choice Serial Reaction Time Task - Nature
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Clozapine-Induced Locomotor Suppression is Mediated by 5-HT - Nature
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Structure-activity relationships of serotonergic 5-MeO-DMT derivatives: insights into psychoactive and thermoregulatory properties | Molecular Psychiatry - Nature
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Trait sensitivity to negative feedback in rats is associated with increased expression of serotonin 5-HT - frontiersin.org
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Evidence for the Preferential Involvement of 5-HT2A Serotonin Receptors in Stress- and Drug-Induced Dopamine Release in the Rat Medial Prefrontal Cortex - Nature
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Serotonin Syndrome: The Role of Pharmacology in Understanding Its Occurrence - Cureus
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Serotonin-prefrontal cortical circuitry in anxiety and depression phenotypes: pivotal role of pre- and post-synaptic 5-HT1A receptor expression - frontiersin.org
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Receptor Antagonists on Serial Spatial Reversal Learning in Rats - Nature
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5-HT2AR and NMDAR psychedelics induce similar hyper-synchronous states in the rat cognitive-limbic cortex-basal ganglia system | Communications Biology - Nature
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Decreased 5-HT2a Receptor Binding in Patients with Anorexia Nervosa - Journal of Nuclear Medicine
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Recent advances in understanding adverse effects associated with drugs targeting the serotonin receptor, 5-HT GPCR - frontiersin.org
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Serotonin regulates mitochondrial biogenesis and function in rodent cortical neurons via the 5-HT - PNAS
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5-HT2A Receptor-Induced Morphological Reorganization of PKCγ-Expressing Interneurons Gates Inflammatory Mechanical Allodynia in Rat - jneurosci.org
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Towards an understanding of psychedelic-induced neuroplasticity | Neuropsychopharmacology - Nature
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receptor sensitization and inhibits rebound phenomena related to D - Wiley Online Library
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Delix Therapeutics describes new 5-HT2A receptor modulators - BioWorld MedTech
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The Effects of the Preferential 5-HT2A Agonist Psilocybin on Prepulse Inhibition of Startle in Healthy Human Volunteers Depend on Interstimulus Interval - Nature
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Receptor Binding and the T102C Polymorphism in Depressed and Healthy Caucasian Subjects - Nature
Why This Topic Is Trending
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