Why is "5-HT2C" trending?
Latest news, Wikipedia summary, and trend analysis.
Trend Analysis
- Ranking position: #
- Date: 2026-04-21 19:39:14
This topic has appeared in the trending rankings 1 time(s) in the past year. While it does not trend frequently, its appearance suggests a renewed or concentrated surge of public interest.
Based on Wikipedia pageviews and search interest, this topic gained significant attention on the selected date.
Trend Insight
5-HT2C entered the ranking for the first time today at position #. This is its highest position ever recorded.
Trend History
This topic has appeared in the English Wikipedia rankings 1 time. It first appeared on 2026-04-21 and was most recently seen on 2026-04-21.
Wikipedia Overview
The 5-HT2C receptor is a subtype of the 5-HT2 receptor that binds the endogenous neurotransmitter serotonin (5-hydroxytryptamine, 5-HT). Like all 5-HT2 receptors, it is a G protein-coupled receptor (GPCR) that is coupled to Gq/G11 and mediates excitatory neurotransmission. HTR2C denotes the human gene encoding for the receptor, that in humans is located on the X chromosome. As males have one copy of the gene and females have one of the two copies of the gene repressed, polymorphisms at this receptor can affect the two sexes to differing extent.
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Trending Topic Today
Search Interest Perspective
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New 5-HT2C receptor agonists reported in Hansoh patent - BioWorld News
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Chemogenetic modulation of CRF neurons in the BNST compensates for phenotypic behavioral differences in fear extinction learning of 5-HT2C receptor mutant mice - Nature
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Choroid Plexus Secretion Regulates CSF Proteome and Alters Brain Development - Simons Foundation Autism Research Initiative | SFARI
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Unlearning fear faster - EurekAlert!
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5-HT2C receptors in the nucleus accumbens constrain the rewarding effects of MDMA | Molecular Psychiatry - Nature
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Bright Minds shines with phase 2 win for anti-seizure serotonin receptor activator - Fierce Biotech
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Küleon Bioscience Awarded $2 Million NIAAA Grant to Advance a Novel, Non-Hallucinogenic 5-HT2C Therapeutic Program for Alcohol Use Disorder - Business Wire
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Brain Switch Identified for Unlearning Fear Faster - Neuroscience News
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Newly Initiated Phase 2 BREAKTHROUGH Trial to Test 5-HT2C Receptor Agonist BMB-101 in Drug-Resistant Epilepsies - NeurologyLive
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Dopamine and serotonin inversely modulate D2 medium spiny neurons to regulate cocaine reward - Nature
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Pharmacological Modulation of 5-HT2C Receptor Activity Produces Bidirectional Changes in Locomotor Activity, Responding for a Conditioned Reinforcer, and Mesolimbic DA Release in C57BL/6 Mice | Neuropsychopharmacology - Nature
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Constitutive 5-HT2C receptor knock-out facilitates fear extinction through altered activity of a dorsal raphe-bed nucleus of the stria terminalis pathway | Translational Psychiatry - Nature
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Receptor Cys23Ser Single Nucleotide Polymorphism Associates with Receptor Function and Localization In Vitro - Nature
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receptor: implications for neuropsychopharmacology and neurotherapeutics - Nature
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Sleep and Sleep Homeostasis in Mice Lacking the 5-HT2c Receptor - Nature
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Receptors Potentiates Consequences of Serotonin Reuptake Blockade - Nature
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Subcortical serotonin 5HT2c receptor-containing neurons sex-specifically regulate binge-like alcohol consumption, social, and arousal behaviors in mice - Nature
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Receptor Antagonists on Serial Spatial Reversal Learning in Rats - Nature
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Receptors in the Nucleus Accumbens on Inhibitory Response Control in the 5-Choice Serial Reaction Time Task - Nature
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Activation of Ventral Tegmental Area 5-HT2C Receptors Reduces Incentive Motivation | Neuropsychopharmacology - Nature
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The 5-HT2C Receptor Agonist Lorcaserin Reduces Nicotine Self-Administration, Discrimination, and Reinstatement: Relationship to Feeding Behavior and Impulse Control | Neuropsychopharmacology - Nature
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Ectopic expression of Snord115 in choroid plexus interferes with editing but not splicing of 5-Ht2c receptor pre-mRNA in mice - Nature
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Augmentation of SSRI Effects on Serotonin by 5-HT2C Antagonists: Mechanistic Studies | Neuropsychopharmacology - Nature
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Human loss-of-function variants in the serotonin 2C receptor associated with obesity and maladaptive behavior - Nature
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G proteins of the G12 family expressed by POMC neurons regulate key metabolic functions - Science | AAAS
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Messenger RNA Editing of the Human Serotonin 5-HT2C Receptor | Neuropsychopharmacology - Nature
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Receptor: Alterations in Suicide and Implications for Serotonergic Pharmacotherapy - Nature
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Recovery of motoneuron and locomotor function after spinal cord injury depends on constitutive activity in 5-HT - Nature
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Disruption of PTEN coupling with 5-HT2C receptors suppresses behavioral responses induced by drugs of abuse - Nature
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5-HT2A and 5-HT2C Receptors Exert Opposing Effects on Locomotor Activity in Mice | Neuropsychopharmacology - Nature
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The 5-HT2C Receptor Agonist Ro60-0175 Reduces Cocaine Self-Administration and Reinstatement Induced by the Stressor Yohimbine, and Contextual Cues | Neuropsychopharmacology - Nature
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In Vivo Evidence that 5-HT2C Receptor Antagonist but not Agonist Modulates Cocaine-Induced Dopamine Outflow in the Rat Nucleus Accumbens and Striatum | Neuropsychopharmacology - Nature
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Effects of the 5-HT2C/2B Antagonist SB 206553 on Hyperactivity Induced by Cocaine | Neuropsychopharmacology - Nature
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receptor function: relevance to anxiety and aggression in VGV mice - Nature
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Injection of the 5-HT2C Receptor Agonist Ro60-0175 into the Ventral Tegmental Area Reduces Cocaine-Induced Locomotor Activity and Cocaine Self-Administration | Neuropsychopharmacology - Nature
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Recent advances in understanding adverse effects associated with drugs targeting the serotonin receptor, 5-HT GPCR - Frontiers
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5-HT2A and 5-HT2C/2B Receptor Subtypes Modulate Dopamine Release Induced in Vivo by Amphetamine and Morphine in Both the Rat Nucleus Accumbens and Striatum | Neuropsychopharmacology - Nature
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Central serotonin-2A (5-HT2A) receptor dysfunction in depression and epilepsy: the missing link? - Frontiers
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Neuronal differentiation induces SNORD115 expression and is accompanied by post-transcriptional changes of serotonin receptor 2c mRNA - Nature
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BMB-101 5-HT2C biased agonist overcomes tolerance in chronic epilepsy treatment - BioWorld News
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Lorcaserin (APD356), a Selective 5‐HT2C Agonist, Reduces Body Weight in Obese Men and Women - Wiley Online Library
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Labeling for ADHD Med Qelbree Updated With Lactation, Pharmacodynamic Data - Medical Professionals Reference
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Endogenous Serotonin Excites Striatal Cholinergic Interneurons via the Activation of 5-HT 2C, 5-HT6, and 5-HT7 Serotonin Receptors: Implications for Extrapyramidal Side Effects of Serotonin Reuptake Inhibitors - Nature
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RNA editing of the 5-HT2C receptor is reduced in schizophrenia - Molecular Psychiatry - Nature
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receptor function by Cys23Ser, an abundant, naturally occurring amino-acid substitution - Nature
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CRF receptor 1 antagonism and brain distribution of active components contribute to the ameliorative effect of rikkunshito on stress-induced anorexia - Nature
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An Interaction between Serotonin Receptor Signaling and Dopamine Enhances Goal-Directed Vigor and Persistence in Mice - Journal of Neuroscience
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N -Methlenedioxymethamphetamine-Induced Hypophagia is Maintained in 5-HT - Nature
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FDA Approves Label Update for Viloxazine Capsules to Include New Lactation Data - HCPLive
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Variability of 5-HT2C receptor cys23ser polymorphism among European populations and vulnerability to affective disorder - Nature
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SR46349-B, a 5-HT2A/2C Receptor Antagonist, Potentiates Haloperidol-induced Dopamine Release in Rat Medial Prefrontal Cortex and Nucleus Accumbens | Neuropsychopharmacology - Nature
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Differential Effects of the 5-HT2A Receptor Antagonist M100,907 and the 5-HT2C Receptor Antagonist SB242,084 on Cocaine-induced Locomotor Activity, Cocaine Self-administration and Cocaine-induced Reinstatement of Responding | Neuropsychopharma - Nature
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Serotonin modulates glutamatergic transmission to neurons in the lateral habenula - Nature
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The Effect of Clozapine on Extracellular Dopamine Levels in the Shell Subregion of the Rat Nucleus Accumbens is Reversed Following Chronic Administration: Comparison with a Selective 5-HT2C Receptor Antagonist | Neuropsychopharmacology - Nature
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Radiosynthesis and Evaluation of 11C-CIMBI-5 as a 5-HT2A Receptor Agonist Radioligand for PET - Journal of Nuclear Medicine
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Striatal serotonin 2C receptors decrease nigrostriatal dopamine release by increasing GABA-A receptor tone in the substantia nigra - Wiley Online Library
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Bexicaserin Produces Significant Seizure Reduction in PACIFIC OLE Trial for Developmental and Epileptic Encephalopathies - Applied Clinical Trials Online
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The vital role of constitutive GPCR activity in the mesolimbic dopamine system - Nature
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Receptors in the Behavioral Interactions Between Serotonin and Catecholamine Reuptake Inhibitors - Nature
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receptor modulate operant alcohol self-administration behavior in mice - Nature
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Administration of SCH 23390 into the Medial Prefrontal Cortex Blocks the Expression of MDMA-Induced Behavioral Sensitization in Rats: An Effect Mediated by 5-HT2C Receptor Stimulation and not by D1 Receptor Blockade | Neuropsychopharmacology - Nature
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Mouse study finds that fearlessness can be learned - Medical Xpress
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Magic Mushrooms Guide: Where Shrooms Are Legal and How To Take Psilocybin - Newsweek
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Mechanisms Contributing to the Phase-Dependent Regulation of Neurogenesis by the Novel Antidepressant, Agomelatine, in the Adult Rat Hippocampus | Neuropsychopharmacology - Nature
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Lundbeck Deepens Neuro, Rare Disease Portfolio With $2.6B Longboard Buy - BioSpace
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Are high-speed antidepressants as sweet as they sound? - The Conversation
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Effect of LSD on Prepulse Inhibition and Spontaneous Behavior in the Rat: A Pharmacological Analysis and Comparison between Two Rat Strains - Nature
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5-HT2 Agonist Clinical Trial Pipeline Appears Robust With - GlobeNewswire
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Rewiring the Serotonin System - Neuroscience News
Why This Topic Is Trending
This topic has recently gained attention due to increased public interest. Search activity and Wikipedia pageviews suggest growing global engagement.
Search Interest & Related Topics
Search interest data over the past 12 months indicates that this topic periodically attracts global attention. Sudden spikes often correlate with major news events, public statements, or geopolitical developments.