Why is "5-HT2C receptor" trending?
Latest news, Wikipedia summary, and trend analysis.
Trend Analysis
- Ranking position: #
- Date: 2026-03-16 10:01:26
This topic has appeared in the trending rankings 1 time(s) in the past year. While it does not trend frequently, its appearance suggests a renewed or concentrated surge of public interest.
Based on Wikipedia pageviews and search interest, this topic gained significant attention on the selected date.
Trend Insight
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Wikipedia Overview
The 5-HT2C receptor is a subtype of the 5-HT2 receptor that binds the endogenous neurotransmitter serotonin (5-hydroxytryptamine, 5-HT). Like all 5-HT2 receptors, it is a G protein-coupled receptor (GPCR) that is coupled to Gq/G11 and mediates excitatory neurotransmission. HTR2C denotes the human gene encoding for the receptor, that in humans is located on the X chromosome. As males have one copy of the gene and females have one of the two copies of the gene repressed, polymorphisms at this receptor can affect the two sexes to differing extent.
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Trending Topic Today
Search Interest Perspective
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Chemogenetic modulation of CRF neurons in the BNST compensates for phenotypic behavioral differences in fear extinction learning of 5-HT2C receptor mutant mice - Nature
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Bright Minds shines with phase 2 win for anti-seizure serotonin receptor activator - Fierce Biotech
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5-HT2C receptors in the nucleus accumbens constrain the rewarding effects of MDMA | Molecular Psychiatry - Nature
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Receptor Activation Suppresses Binge Intake and the Reinforcing and Motivational Properties of High-Fat Food - Frontiers
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Receptor Interaction with Phosphatase and Tensin Homolog to Allosterically Modulate Cellular Signaling and Behavior - Journal of Neuroscience
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Constitutive 5-HT2C receptor knock-out facilitates fear extinction through altered activity of a dorsal raphe-bed nucleus of the stria terminalis pathway | Translational Psychiatry - Nature
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Receptor Antagonists on Serial Spatial Reversal Learning in Rats - Nature
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Receptor Cys23Ser Single Nucleotide Polymorphism Associates with Receptor Function and Localization In Vitro - Nature
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Serotonin 5-HT2C receptor knockout in mice attenuates fear responses in contextual or cued but not compound context-cue fear conditioning | Translational Psychiatry - Nature
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Pharmacological Modulation of 5-HT2C Receptor Activity Produces Bidirectional Changes in Locomotor Activity, Responding for a Conditioned Reinforcer, and Mesolimbic DA Release in C57BL/6 Mice | Neuropsychopharmacology - Nature
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Sleep and Sleep Homeostasis in Mice Lacking the 5-HT2c Receptor - Nature
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receptor: implications for neuropsychopharmacology and neurotherapeutics - Nature
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receptor function: relevance to anxiety and aggression in VGV mice - Nature
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Ectopic expression of Snord115 in choroid plexus interferes with editing but not splicing of 5-Ht2c receptor pre-mRNA in mice - Nature
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The 5-HT2C Receptor Agonist Ro60-0175 Reduces Cocaine Self-Administration and Reinstatement Induced by the Stressor Yohimbine, and Contextual Cues | Neuropsychopharmacology - Nature
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The 5-HT2C Receptor Agonist Lorcaserin Reduces Nicotine Self-Administration, Discrimination, and Reinstatement: Relationship to Feeding Behavior and Impulse Control | Neuropsychopharmacology - Nature
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Receptor: Alterations in Suicide and Implications for Serotonergic Pharmacotherapy - Nature
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Decreased Incentive Motivation Following Knockout or Acute Blockade of the Serotonin Transporter: Role of the 5-HT - Nature
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In Vivo Evidence that 5-HT2C Receptor Antagonist but not Agonist Modulates Cocaine-Induced Dopamine Outflow in the Rat Nucleus Accumbens and Striatum | Neuropsychopharmacology - Nature
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Injection of the 5-HT2C Receptor Agonist Ro60-0175 into the Ventral Tegmental Area Reduces Cocaine-Induced Locomotor Activity and Cocaine Self-Administration | Neuropsychopharmacology - Nature
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RNA Editing of Serotonin 2C Receptor and Alcohol Intake - Frontiers
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Variability of 5-HT2C receptor cys23ser polymorphism among European populations and vulnerability to affective disorder - Nature
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receptor function by Cys23Ser, an abundant, naturally occurring amino-acid substitution - Nature
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Beyond the 5-HT2A Receptor: Classic and Nonclassic Targets in Psychedelic Drug Action - Journal of Neuroscience
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Messenger RNA Editing of the Human Serotonin 5-HT2C Receptor | Neuropsychopharmacology - Nature
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BMB-101 5-HT2C biased agonist overcomes tolerance in chronic epilepsy treatment - BioWorld MedTech
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Unlearning fear faster - EurekAlert!
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Augmentation of SSRI Effects on Serotonin by 5-HT2C Antagonists: Mechanistic Studies | Neuropsychopharmacology - Nature
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New Class of Drugs Shows Promise for the Treatment of Schizophrenia in Animal Models - Brain and Behavior Research
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N -Methlenedioxymethamphetamine-Induced Hypophagia is Maintained in 5-HT - Nature
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Mouse study finds that fearlessness can be learned - Medical Xpress
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Receptors Potentiates Consequences of Serotonin Reuptake Blockade - Nature
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Differential Effects of the 5-HT2A Receptor Antagonist M100,907 and the 5-HT2C Receptor Antagonist SB242,084 on Cocaine-induced Locomotor Activity, Cocaine Self-administration and Cocaine-induced Reinstatement of Responding | Neuropsychopharma - Nature
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Labeling for ADHD Med Qelbree Updated With Lactation, Pharmacodynamic Data - MPR - Medical Professionals Reference
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Bexicaserin Shows Promise for Developmental Epileptic Encephalopathies in Phase 1b/2a PACIFIC Extension - Neurology Live
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Administration of SCH 23390 into the Medial Prefrontal Cortex Blocks the Expression of MDMA-Induced Behavioral Sensitization in Rats: An Effect Mediated by 5-HT2C Receptor Stimulation and not by D1 Receptor Blockade | Neuropsychopharmacology - Nature
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Lundbeck Deepens Neuro, Rare Disease Portfolio With $2.6B Longboard Buy - BioSpace
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The Effect of Clozapine on Extracellular Dopamine Levels in the Shell Subregion of the Rat Nucleus Accumbens is Reversed Following Chronic Administration: Comparison with a Selective 5-HT2C Receptor Antagonist | Neuropsychopharmacology - Nature
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Understanding fear extinction to help treat PTSD - Advanced Science News
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Longboard Stock Skyrockets on Positive Epilepsy Data, Plans $150M Public Offering - BioSpace
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Label Update for ADHD Treatment Qelbree: New Pharmacodynamic Data and Breastfeeding Information - Psychiatric Times
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A genetically encoded sensor to measure serotonin dynamics in vivo - Medical Xpress
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Lundbeck signs $2.5B check for Longboard, seeing blockbuster potential in epilepsy med - Fierce Biotech
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Add-On Nuplazid Gets a Win in Early Schizophrenia Trial - MedPage Today
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Societal CDMO Selected by Longboard Pharmaceuticals to - GlobeNewswire
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Lundbeck’s Neuro-Rare Pipeline Lands Cornerstone Drug via $2.6B Longboard Pharma Acquisition - MedCity News
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Rewiring the Serotonin System - Neuroscience News
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Longboard Pharmaceuticals Announces Positive Topline Data from the PACIFIC Study, a Phase 1b/2a Clinical Trial, for Bexicaserin (LP352) in Participants with Developmental and Epileptic Encephalopathies (DEEs) - Business Wire
Why This Topic Is Trending
This topic has recently gained attention due to increased public interest. Search activity and Wikipedia pageviews suggest growing global engagement.
Search Interest & Related Topics
Search interest data over the past 12 months indicates that this topic periodically attracts global attention. Sudden spikes often correlate with major news events, public statements, or geopolitical developments.