Why is "5-Hydroxymethylcytosine" trending?

Search Interest Perspective

• Profiling of 5-hydroxymethylcytosine in blood reveals preferential enrichment at exon-intron junctions and predictive value for Parkinson’s disease - Nature
• SCoTCH-seq reveals that 5-hydroxymethylcytosine encodes regulatory information across DNA strands - PNAS
• Direct Sequencing of 5-Methylcytosine and 5-Hydroxymethylcytosine at Single-Base Resolution Unravels Their Distinct Roles in Alzheimer's Disease - Wiley
• Sequencing method gets genetic and epigenetic information from the same molecule - C&EN
• 5-methylcytosine and 5-hydroxymethylcytosine are synergistic biomarkers for early detection of colorectal cancer - Nature
• Research progress on DNA hydroxymethylation in atrial fibrillation: a review - Frontiers
• TET3-Interacting LncRNA TILR Is Essential for DNA Hydroxymethylation–Mediated Neuroprotection After Ischemic Stroke - American Heart Association Journals
• Reduced 5-hydroxymethylcytosine due to TET2 downregulation is associated with chondrosarcoma progression - Nature
• Beyond Five Bases: See What Your Data’s Missing - Technology Networks
• 5-hydroxymethylcytosine analysis reveals stable epigenomic changes in tumor tissue that enable cancer detection in cell-free DNA - Nature
• Mammalian Proteome Profiling Reveals Readers and Antireaders of Strand-Symmetric and -Asymmetric 5-Hydroxymethylcytosine-Modifications in DNA - Wiley
• 5-hydroxymethylcytosine profiles in circulating cell-free DNA associate with disease status in patients with osteosarcoma | npj Precision Oncology - Nature
• Tet Methylcytosine Dioxygenase 3 Promotes Cardiovascular Senescence by DNA 5-Hydroxymethylcytosine-Mediated Sp1 Transcription Factor Expression - Wiley Online Library
• 5-Hydroxymethylcytosine signatures as diagnostic biomarkers for septic cardiomyopathy - Nature
• Immunohistochemical detection of 5-hydroxymethylcytosine as a prognostic biomarker in non-WNT/Non-SHH medulloblastomas - Nature
• A bacterial defense system targeting modified cytosine of phage genomic DNA - Nature
• Tissue-specific 5-hydroxymethylcytosine landscape of the human genome - Nature
• Sequencing DNA methylation and hydroxymethylation at co-occurring chromatin features - Nature
• Brain 5-hydroxymethylcytosine alterations are associated with Alzheimer’s disease neuropathology - Nature
• Distinct dynamics of parental 5-hydroxymethylcytosine during human preimplantation development regulate early lineage gene expression - Nature
• Double and single stranded detection of 5-methylcytosine and 5-hydroxymethylcytosine with nanopore sequencing - Nature
• 5-hydroxymethylcytosine and gene activity in mouse intestinal differentiation - Nature
• Nondestructive, base-resolution sequencing of 5-hydroxymethylcytosine using a DNA deaminase - Nature
• Detection of early stage pancreatic cancer using 5-hydroxymethylcytosine signatures in circulating cell free DNA - Nature
• The role of DNA methylation and demethylation in bladder cancer: a focus on therapeutic strategies - Frontiers
• Bisulfite-free direct detection of 5-methylcytosine and 5-hydroxymethylcytosine at base resolution - Nature
• 5-Hydroxymethylcytosine signatures in cell-free DNA provide information about tumor types and stages - Nature
• Spurious transcription causing innate immune responses is prevented by 5-hydroxymethylcytosine - Nature
• Cell-free DNA 5-hydroxymethylcytosine is an emerging marker of acute myeloid leukemia - Nature
• 5-Hydroxymethylcytosine localizes to enhancer elements and is associated with survival in glioblastoma patients - Nature
• 5-hydroxymethylcytosine sequencing of plasma cell-free DNA identifies epigenomic features in prostate cancer patients receiving androgen deprivation therapies | Communications Medicine - Nature
• Plasma cell-free DNA 5-hydroxymethylcytosine and whole-genome sequencing signatures for early detection of esophageal cancer - Nature
• Deciphering TAL effectors for 5-methylcytosine and 5-hydroxymethylcytosine recognition - Nature
• Loss of 5-hydroxymethylcytosine induces chemotherapy resistance in hepatocellular carcinoma via the 5-hmC/PCAF/AKT axis - Nature
• 5-Hydroxymethylcytosine signatures in circulating cell-free DNA as diagnostic biomarkers for human cancers - Nature
• Dissecting the dynamic changes of 5-hydroxymethylcytosine in T-cell development and differentiation - PNAS
• 5-hydroxymethylcytosine Marks Mammalian Origins Acting as a Barrier to Replication - Nature
• Exploring the epigenetic landscape: The role of 5-hydroxymethylcytosine in neurodevelopmental disorders - Cambridge University Press & Assessment
• Dynamics of 5-hydroxymethylcytosine during mouse spermatogenesis - Nature
• Selective chemical labeling reveals the genome-wide distribution of 5-hydroxymethylcytosine - Nature
• A hybrid residue based sequential encoding mechanism with XGBoost improved ensemble model for identifying 5-hydroxymethylcytosine modifications - Nature
• TET Enzymes and 5-Hydroxymethylcytosine in Neural Progenitor Cell Biology and Neurodevelopment - Frontiers
• Genome-wide mapping of 5-hydroxymethylcytosine in embryonic stem cells - Nature
• Genome-wide profiling of DNA 5-hydroxymethylcytosine during rat Sertoli cell maturation - Nature
• Loss of 5-hydroxymethylcytosine is linked to gene body hypermethylation in kidney cancer - Nature
• Genome-wide 5-hydroxymethylcytosine (5hmC) emerges at early stage of in vitro differentiation of a putative hepatocyte progenitor - Nature
• Sequence based model using deep neural network and hybrid features for identification of 5-hydroxymethylcytosine modification | Scientific Reports - Nature
• Mutations along a TET2 active site scaffold stall oxidation at 5-hydroxymethylcytosine - Nature
• Uncovering the role of 5-hydroxymethylcytosine in the epigenome - Nature
• 5-Hydroxymethylcytosine in the mammalian zygote is linked with epigenetic reprogramming - Nature
• NSUN5/TET2-directed chromatin-associated RNA modification of 5-methylcytosine to 5-hydroxymethylcytosine governs glioma immune evasion - PNAS
• Epigenomic landscape of 5-hydroxymethylcytosine reveals its transcriptional regulation of lncRNAs in colorectal cancer - Nature
• Conversion of 5-Methylcytosine to 5-Hydroxymethylcytosine in Mammalian DNA by MLL Partner TET1 - Science | AAAS
• Neocortical Tet3-mediated accumulation of 5-hydroxymethylcytosine promotes rapid behavioral adaptation - PNAS
• PPARγ-induced PARylation promotes local DNA demethylation by production of 5-hydroxymethylcytosine - Nature
• Sensitive and specific single-molecule sequencing of 5-hydroxymethylcytosine - Nature
• 5-hydroxymethylcytosine loss is associated with poor prognosis for patients with WHO grade II diffuse astrocytomas - Nature
• Dynamic regulation of 5-hydroxymethylcytosine in mouse ES cells and during differentiation - Nature
• 5-Hydroxymethylcytosine profilings in circulating cell-free DNA as diagnostic biomarkers for DLBCL - Frontiers
• TET-catalyzed 5-hydroxymethylcytosine regulates gene expression in differentiating colonocytes and colon cancer - Nature
• Immunohistochemical evaluation of nuclear 5-hydroxymethylcytosine (5-hmC) accurately distinguishes malignant pleural mesothelioma from benign mesothelial proliferations - Nature
• A human tissue map of 5-hydroxymethylcytosines exhibits tissue specificity through gene and enhancer modulation - Nature
• Role of Tet1 and 5-hydroxymethylcytosine in cocaine action - Nature
• Loss of 5-hydroxymethylcytosine correlates with increasing morphologic dysplasia in melanocytic tumors - Nature
• Subtraction-free and bisulfite-free specific sequencing of 5-methylcytosine and its oxidized derivatives at base resolution - Nature
• tet2 and tet3 regulate cell fate specification and differentiation events during retinal development - Nature
• Functional role of Tet-mediated RNA hydroxymethylcytosine in mouse ES cells and during differentiation - Nature
• The hypomethylating agent Decitabine causes a paradoxical increase in 5-hydroxymethylcytosine in human leukemia cells - Nature
• Mapping DNA methylation with high-throughput nanopore sequencing - Nature
• Subtelomeric hotspots of aberrant 5-hydroxymethylcytosine-mediated epigenetic modifications during reprogramming to pluripotency - Nature
• Dynamics of 5-methylcytosine and 5-hydroxymethylcytosine during germ cell reprogramming | Cell Research - Nature
• Interaction preferences between protein side chains and key epigenetic modifications 5-methylcytosine, 5-hydroxymethycytosine and N6-methyladenine | Scientific Reports - Nature
• TET (Ten-eleven translocation) family proteins: structure, biological functions and applications - Nature
• New Insights into 5hmC DNA Modification: Generation, Distribution and Function - Frontiers
• Associations in cell type-specific hydroxymethylation and transcriptional alterations of pediatric central nervous system tumors - Nature
• DNA hydroxymethylation controls cardiomyocyte gene expression in development and hypertrophy - Nature
• Ten-eleven translocation 1 mediated-DNA hydroxymethylation is required for myelination and remyelination in the mouse brain - Nature
• Genome-wide hydroxymethylcytosine pattern changes in response to oxidative stress - Nature
• The emerging role of 5-hydroxymethylcytosine in neurodegenerative diseases - Frontiers
• Hydroxymethylation profile of cell-free DNA is a biomarker for early colorectal cancer - Nature
• A postreplicative C5-cytosine hypermodification triggered by bacteriophage methyltransferase and hydroxylase - PNAS
• Quantifying mammalian genomic DNA hydroxymethylcytosine content using solid-state nanopores - Nature
• Higher 5-hydroxymethylcytosine identifies immortal DNA strand chromosomes in asymmetrically self-renewing distributed stem cells - PNAS
• Species-Specific 5 mC and 5 hmC Genomic Landscapes Indicate Epigenetic Contribution to Human Brain Evolution - Frontiers
• Nitric oxide inhibits ten-eleven translocation DNA demethylases to regulate 5mC and 5hmC across the genome - Nature
• Gene body DNA hydroxymethylation restricts the magnitude of transcriptional changes during aging - Nature
• Active DNA demethylation of developmental cis-regulatory regions predates vertebrate origins - Science | AAAS
• Simultaneous sequencing of genetic and epigenetic bases in DNA - Nature
• 5-Hydroxymethylcytosine expression in metastatic melanoma versus nodal nevus in sentinel lymph node biopsies - Nature
• Gene-body 5-hydroxymethylation is associated with gene expression changes in the prefrontal cortex of depressed individuals - Nature
• Succinate dehydrogenase deficiency is associated with decreased 5-hydroxymethylcytosine production in gastrointestinal stromal tumors: implications for mechanisms of tumorigenesis - Nature
• Mechanistic insights into the recognition of 5-methylcytosine oxidation derivatives by the SUVH5 SRA domain - Nature
• TET Enzymes and 5hmC in Adaptive and Innate Immune Systems - Frontiers
• Elevated 5hmC levels characterize DNA of the cerebellum in Parkinson’s disease - Nature
• Genome-wide hydroxymethylation profiles in liver of female Nile tilapia with distinct growth performance | Scientific Data - Nature
• Induction of DNA Hydroxymethylation Protects the Brain After Stroke - American Heart Association Journals
• Lineage-specific distribution of high levels of genomic - Cell Research - Nature
• The level of active DNA demethylation compounds in leukocytes and urine samples as potential epigenetic biomarkers in breast cancer patients - Nature
• Epigenetics of Modified DNA Bases: 5-Methylcytosine and Beyond - Frontiers
• Diversity of two forms of DNA methylation in the brain - Frontiers