Why is "6-Diazo-5-oxo-L-norleucine" trending?
Latest news, Wikipedia summary, and trend analysis.
Trend Analysis
- Ranking position: #
- Date: 2026-03-13 10:57:03
This topic has appeared in the trending rankings 1 time(s) in the past year. While it does not trend frequently, its appearance suggests a renewed or concentrated surge of public interest.
Based on Wikipedia pageviews and search interest, this topic gained significant attention on the selected date.
Trend Insight
6-Diazo-5-oxo-L-norleucine entered the ranking for the first time today at position #. This is its highest position ever recorded.
Trend History
This topic has appeared in the English Wikipedia rankings 1 time. It first appeared on 2026-03-13 and was most recently seen on 2026-03-13.
Wikipedia Overview
6-Diazo-5-oxo-L-norleucine (DON) is a glutamine antagonist, which was isolated originally from Streptomyces in a sample of Peruvian soil. This diazo compound is biosynthesized from lysine by three enzymes in bacteria. It is one of the most famous non-proteinogenic amino acid and was characterized in 1956 by Henry W Dion et al., who suggested a possible use in cancer therapy. This antitumoral efficacy was confirmed in different animal models. DON was tested as chemotherapeutic agent in different clinical studies, but was never approved. In 2019, DON was shown to kill tumor cells while reversing disease symptoms and improve overall survival in late-stage experimental glioblastoma in mice, when combined with calorie-restricted ketogenic diet.
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Trending Topic Today
Search Interest Perspective
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Discovery of DRP-104, a tumor-targeted metabolic inhibitor prodrug - Science | AAAS
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Newfound Mechanism Suggests Drug Combination Could Starve Pancreatic Cancer - NYU Langone Health
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Exploiting the Achilles’ heel of cancer: disrupting glutamine metabolism for effective cancer treatment - Frontiers
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Beyond the tumor: Enhancing pancreatic cancer therapy through glutamine metabolism and innovative drug delivery - onlinelibrary.wiley.com
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Targeting pancreatic cancer metabolic dependencies through glutamine antagonism - Nature
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Johns Hopkins Researchers Design ‘Prodrug’ That Targets Cancer Cells’ Big Appetite for Glutamine, Leaving Healthy Cells Unharmed - Johns Hopkins Medicine
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New Prodrug Targets Cancer Cells Appetite for Glutamine; Eliminates Cancer Without Causing Toxicity - Onco'Zine
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Rethinking glutamine metabolism and the regulation of glutamine addiction by oncogenes in cancer - Frontiers
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Reprogramming macrophage immunometabolism via glutamine antagonism potentiates colorectal cancer therapy in mice - Nature
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Drug Helps Reprogram Macrophage Immune Cells, Suppress Prostate and Bladder Tumor Growth - Johns Hopkins Medicine
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Cell polarity proteins promote macropinocytosis in response to metabolic stress - Nature
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Exploring the metabolic signaling network of GFPT in cancer - Nature
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Revolutionizing cancer treatment with Halomonas Aquamarina L-Glutaminase: insights from in vitro and computational studies - Nature
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Disrupting glutamine metabolic pathways to sensitize gemcitabine-resistant pancreatic cancer - Nature
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Glutamine metabolism inhibition has dual immunomodulatory and antibacterial activities against Mycobacterium tuberculosis - Nature
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Additive effects of inhibiting both mTOR and glutamine metabolism on the arthritis in SKG mice - Nature
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Structural Basis for the Active Site Inhibition Mechanism of Human Kidney-Type Glutaminase (KGA) - Nature
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Therapeutic benefit of combining calorie-restricted ketogenic diet and glutamine targeting in late-stage experimental glioblastoma - Nature
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High expression of GFAT1 predicts poor prognosis in patients with pancreatic cancer | Scientific Reports - Nature
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Targeting Abnormal Cell Metabolism Shows Promise for Treating Aggressive Pediatric Brain Tumors - Johns Hopkins Medicine
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Targeting glutamine metabolism rescues mice from late-stage cerebral malaria - PNAS
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Discovery of Novel Glutamine Antagonist Prodrugs: A Story From Bench 2 Bedside - Technology Networks
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David A. Karnofsky’s Early Contributions to Cancer Research Helped Establish Oncology as a Medical Discipline - The ASCO Post
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International projects spearheaded by Children’s National Neurology leaders - Children's National
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High-resolution crystal structure of human asparagine synthetase enables analysis of inhibitor binding and selectivity - Nature
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CNS GNPDA2 Does Not Control Appetite, but Regulates Glucose Homeostasis - Frontiers
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Forming cytoophidia prolongs the half-life of CTP synthase - Nature
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Complete Biosynthetic Pathway of Alazopeptin, a Tripeptide Consisting of Two Molecules of 6‐Diazo‐5‐oxo‐l‐norleucine and One Molecule of Alanine - onlinelibrary.wiley.com
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Help Stephen MacDonald beat cancer - Cayman Marl Road
Why This Topic Is Trending
This topic has recently gained attention due to increased public interest. Search activity and Wikipedia pageviews suggest growing global engagement.
Search Interest & Related Topics
Search interest data over the past 12 months indicates that this topic periodically attracts global attention. Sudden spikes often correlate with major news events, public statements, or geopolitical developments.