Why is "8-Oxoguanine" trending?

Search Interest Perspective

• Direct detection of 8-oxo-dG using nanopore sequencing - Nature
• 8-oxoguanine riboswitches in bacteria detect and respond to oxidative DNA damage - PNAS
• Roles for the 8-Oxoguanine DNA Repair System in Protecting Telomeres From Oxidative Stress - Frontiers
• 8-Oxoguanine: from oxidative damage to epigenetic and epitranscriptional modification - Nature
• Concordance of hydrogen peroxide–induced 8-oxo-guanine patterns with two cancer mutation signatures of upper GI tract tumors - Science | AAAS
• Overview of distinct 8-oxoguanine profiles of messenger RNA in normal and senescent cancer cells - Frontiers
• Click-code-seq reveals strand biases of DNA oxidation and depurination in human genome - Nature
• OGG1 and MUTYH repair activities promote telomeric 8-oxoguanine induced senescence in human fibroblasts - Nature
• Human 8-oxoguanine glycosylase OGG1 binds nucleosome at the dsDNA ends and the super-helical locations - Nature
• Widespread 8-oxoguanine modifications of miRNA seeds differentially regulate redox-dependent cancer development - Nature
• MTH1 and OGG1 maintain a low level of 8-oxoguanine in Alzheimer's brain, and prevent the progression of Alzheimer's pathogenesis - Nature
• Small molecule-mediated allosteric activation of the base excision repair enzyme 8-oxoguanine DNA glycosylase and its impact on mitochondrial function - Nature
• Structural basis of DNA synthesis opposite 8-oxoguanine by human PrimPol primase-polymerase - Nature
• The trajectory of intrahelical lesion recognition and extrusion by the human 8-oxoguanine DNA glycosylase - Nature
• Circadian Modulation of 8-Oxoguanine DNA Damage Repair - Nature
• Telomeric 8-oxo-guanine drives rapid premature senescence in the absence of telomere shortening - Nature
• Global and transcription-coupled repair of 8-oxoG is initiated by nucleotide excision repair proteins - Nature
• Impact of cryopreservation on DNA damage in Acer platanoides L. seeds evaluated by the comet assay - Nature
• 8-OxoG in GC-rich Sp1 binding sites enhances gene transcription in adipose tissue of juvenile mice - Nature
• 8-oxoguanine causes spontaneous de novo germline mutations in mice - Nature
• Contributing factors to the oxidation-induced mutational landscape in human cells - Nature
• Replication protein A and proliferating cell nuclear antigen coordinate DNA polymerase selection in 8-oxo-guanine repair - PNAS
• Efficient UV-induced charge separation and recombination in an 8-oxoguanine-containing dinucleotide - PNAS
• Structure of human MUTYH and functional profiling of cancer-associated variants reveal an allosteric network between its [4Fe-4S] cluster cofactor and active site required for DNA repair - Nature
• 8-Oxoguanine accumulation in mitochondrial DNA causes mitochondrial dysfunction and impairs neuritogenesis in cultured adult mouse cortical neurons under oxidative conditions - Nature
• OGG1-DNA interactions facilitate NF-κB binding to DNA targets - Nature
• The two faces of DNA oxidation in genomic and functional mosaicism during aging in human neurons - Frontiers
• UVA radiation is highly mutagenic in cells that are unable to repair 7,8-dihydro-8-oxoguanine in Saccharomyces cerevisiae - PNAS
• Mitochondrial repair of 8-oxoguanine is deficient in Cockayne syndrome group B - Nature
• An 8-oxo-guanine repair pathway coordinated by MUTYH glycosylase and DNA polymerase λ - PNAS
• 8-Oxoguanine causes neurodegeneration during MUTYH-mediated DNA base excision repair - jci.org
• Transcriptional coupling and repair of 8-OxoG activate a RecA-dependent checkpoint that controls the onset of sporulation in Bacillus subtilis - Nature
• Structural basis for removal of adenine mispaired with 8-oxoguanine by MutY adenine DNA glycosylase - Nature
• Transcriptional mutagenesis by 8-oxodG in α-synuclein aggregation and the pathogenesis of Parkinson’s disease - Nature
• Structural insights into lesion recognition and repair by the bacterial 8-oxoguanine DNA glycosylase MutM - Nature
• Putting the Brakes on Huntington Disease in a Mouse Experimental Model - PLOS
• Limiting oxidative DNA damage reduces microbe-induced colitis-associated colorectal cancer - Nature
• Post-transcriptional air pollution oxidation to the cholesterol biosynthesis pathway promotes pulmonary stress phenotypes | Communications Biology - Nature
• The E3 Ubiquitin Ligase NEDD4L Targets OGG1 for Ubiquitylation and Modulates the Cellular DNA Damage Response - Frontiers
• Human 8-oxoguanine DNA glycosylase increases resistance to hyperoxic cytotoxicity in lung epithelial cells and involvement with altered MAPK activity - Nature
• DNA interstrand cross-links induced by the major oxidative adenine lesion 7,8-dihydro-8-oxoadenine - Nature
• Atomic-level, 3-D structure of MUTYH protein opens small window into DNA repair mechanism - EurekAlert!
• MUTYH DNA glycosylase: the rationale for removing undamaged bases from the DNA - Frontiers
• Creation of RNA molecules that recognize the oxidative lesion 7,8-dihydro-8-hydroxy-2′-deoxyguanosine (8-oxodG) in DNA - PNAS
• Base excision repair of adenine/8-oxoguanine mispairs by an aphidicolin-sensitive DNA polymerase in human cell extracts - Nature
• hSSB1 (NABP2/OBFC2B) is regulated by oxidative stress - Nature
• Atomic substitution reveals the structural basis for substrate adenine recognition and removal by adenine DNA glycosylase - PNAS
• Endogenous oxidized DNA bases and APE1 regulate the formation of G-quadruplex structures in the genome - PNAS
• 8-oxo-guanine bypass by human DNA polymerases in the presence of auxiliary proteins - Nature
• RNA oxidation in chromatin modification and DNA-damage response following exposure to formaldehyde - Nature
• Small-molecule inhibitor of OGG1 suppresses proinflammatory gene expression and inflammation - Science | AAAS
• MUTYH, an adenine DNA glycosylase, mediates p53 tumor suppression via PARP-dependent cell death - Nature
• Efficient and accurate replication in the presence of 7,8-dihydro-8-oxoguanine by DNA polymerase η - Nature
• Development and Application of a Chemical Labeling-Based Biosensing Assay for Rapid Detection of 8-Oxoguanine and Its Repair in vitro and in Human Cells - Wiley Online Library
• DNA damage and cell death assessment in patients with severe multiple trauma using comet assay - SCIRP Open Access
• Human monocytes are severely impaired in base and DNA double-strand break repair that renders them vulnerable to oxidative stress - PNAS
• Oxidative DNA damage stalls the human mitochondrial replisome - Nature
• Oxidative Modifications of RNA and Its Potential Roles in Biosystem - Frontiers
• MTH1, an oxidized purine nucleoside triphosphatase, protects the dopamine neurons from oxidative damage in nucleic acids caused by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine - Nature
• Specific binding of PCBP1 to heavily oxidized RNA to induce cell death - PNAS
• Oxidation and alkylation stresses activate ribosome-quality control - Nature
• How chemicals can speed up evolution - New Scientist
• Global genome repair of 8-oxoG in hamster cells requires a functional CSB gene product - Nature