Why is "ABCA1" trending?

Search Interest Perspective

• Cholesterol efflux protein, ABCA1, supports anticancer functions of myeloid immune cells - Science | AAAS
• UBE3A promotes foam cell formation and counters remyelination by targeting ABCA1 for proteasomal degradation - Nature
• ABCA1 protein releases molecular brakes on solid tumor immunotherapy, study finds - Medical Xpress
• Tissue Specific Role of ABCA1 in Lung Cholesterol Homeostasis under High-Cholesterol Diet - Frontiers
• How is good cholesterol made? - EurekAlert!
• Antisense oligonucleotide targeting TARDBP-EGFR splicing axis inhibits progression of oral squamous cell carcinoma through ABCA1-regulated cholesterol efflux - Nature
• The secret life of ‘good cholesterol’ revealed - Wiley Analytical Science
• Specific Loss of ABCA1 (ATP-Binding Cassette Transporter A1) Suppresses TCR (T-Cell Receptor) Signaling and Provides Protection Against Atherosclerosis - American Heart Association Journals
• TNFα induces ABCA1 through NF-κB in macrophages and in phagocytes ingesting apoptotic cells - PNAS
• Traditional Chinese medicine monomers: a new strategy against diabetic kidney disease by regulating cholesterol efflux - Frontiers
• Correction: Antisense oligonucleotide targeting TARDBP-EGFR splicing axis inhibits progression of oral squamous cell carcinoma through ABCA1-regulated cholesterol efflux - Nature
• Astrocytic dysfunction induced by ABCA1 deficiency causes optic neuropathy - Science | AAAS
• Flipped C-Terminal Ends of APOA1 Promote ABCA1-Dependent Cholesterol Efflux by Small HDLs - American Heart Association Journals
• Leukocyte ABCA1 controls susceptibility to atherosclerosis and macrophage recruitment into tissues - PNAS
• Saffron as a natural modulator of reverse cholesterol transport genes in atherosclerotic rabbits, with molecular docking insights - Nature
• Correction: Celastrol induces lipophagy via the LXRα/ABCA1 pathway in clear cell renal cell carcinoma - Nature
• Compounds targeting OSBPL7 increase ABCA1-dependent cholesterol efflux preserving kidney function in two models of kidney disease - Nature
• Exome sequencing identifies rare damaging variants in ATP8B4 and ABCA1 as risk factors for Alzheimer’s disease - Nature
• Expression analysis of ABCA1 in type 2 diabetic Pakistani patients with and without dyslipidemia and correlation with glycemic index and lipid profile | Scientific Reports - Nature
• Novel interactomics approach identifies ABCA1 as direct target of evodiamine, which increases macrophage cholesterol efflux - Nature
• Targeted Deletion of Adipocyte Abca1 (ATP-Binding Cassette Transporter A1) Impairs Diet-Induced Obesity - American Heart Association Journals
• Association between the ABCA1 (R219K) polymorphism and lipid profiles: a meta-analysis - Nature
• CCDC92 promotes podocyte injury by regulating PA28α/ABCA1/cholesterol efflux axis in type 2 diabetic mice - Nature
• SMC Abca1 and Abcg1 Deficiency Enhances Urinary Bladder Distension but Not Atherosclerosis - American Heart Association Journals
• Cholesterol accumulation promotes ABCA1 degradation in astrocytes via Caveolin-1 mediated endocytosis in ApoE4 - Wiley
• ApoE4 Alters ABCA1 Membrane Trafficking in Astrocytes - Journal of Neuroscience
• E17241 as a Novel ABCA1 (ATP-Binding Cassette Transporter A1) Upregulator Ameliorates Atherosclerosis in Mice - American Heart Association Journals
• ABCA1 deficiency contributes to podocyte pyroptosis priming via the APE1/IRF1 axis in diabetic kidney disease - Nature
• adipose tissue macrophages and post-prandial cholesterol levels - Nature
• Inflammatory corpuscle AIM2 facilitates macrophage foam cell formation by inhibiting cholesterol efflux protein ABCA1 - Nature
• Targeted Deletion of Hepatocyte Abca1 Increases Plasma HDL (High-Density Lipoprotein) Reverse Cholesterol Transport via the LDL (Low-Density Lipoprotein) Receptor - American Heart Association Journals
• Reactive astrocytes function as phagocytes after brain ischemia via ABCA1-mediated pathway - Nature
• Complete genomic sequence of the human ABCA1 gene: Analysis of the human and mouse ATP-binding cassette A promoter - PNAS
• Temporary sequestration of cholesterol and phosphatidylcholine within extracellular domains of ABCA1 during nascent HDL generation - Nature
• Structural properties of apolipoprotein A-I mimetic peptides that promote ABCA1-dependent cholesterol efflux - Nature
• Elucidating the Structural Features of ABCA1 in its Heterogeneous Membrane Environment - Frontiers
• Celastrol induces lipophagy via the LXRα/ABCA1 pathway in clear cell renal cell carcinoma - Nature
• Integrated analysis of m6A regulator mediated RNA methylation and key immune related genes in ischemic stroke - Nature
• ABCA1 promote tumor environment heterogeneity via epithelial mesenchymal transition in Huh7 and HepG2 liver cancer cell - Frontiers
• ABCA1 and Inflammation: - American Heart Association Journals
• New insights into cholesterol efflux via ABCA1 - Nature
• LXRβ controls glioblastoma cell growth, lipid balance, and immune modulation independently of ABCA1 - Nature
• ApoE4 requires lipidation enhancement to resolve cellular lipid and protein abnormalities following NPC1 inhibition - Nature
• FTY720 Modulating Microglia-Mediated Cholesterol Recycling via TREM2 Promotes Remyelination Following Ischemic Damage | Stroke - American Heart Association Journals
• Proteus mirabilis Vesicles Induce Mitochondrial Apoptosis by Regulating miR96-5p/Abca1 to Inhibit Osteoclastogenesis and Bone Loss - Frontiers
• Exome sequencing identifies rare damaging variants in the ATB8B4 and ABCA1 genes as novel risk factors for Alzheimer’s disease - Wiley
• ABCA1-Derived Nascent High-Density Lipoprotein–Apolipoprotein AI and Lipids Metabolically Segregate - American Heart Association Journals
• Difference in expression patterns of placental cholesterol transporters, ABCA1 and SR-BI, in Meishan and Yorkshire pigs with different placental efficiency - Nature
• The role of ABCB1 and ABCA1 in beta-amyloid clearance at the neurovascular unit in Alzheimer's disease - Frontiers
• ABCA1 dimer–monomer interconversion during HDL generation revealed by single-molecule imaging - PNAS
• IRAK1 mediates TLR4-induced ABCA1 downregulation and lipid accumulation in VSMCs - Nature
• Tetrandrine ameliorated atherosclerosis in vitamin D3/high cholesterol diet-challenged rats via modulation of miR-34a and Wnt5a/Ror2/ABCA1/NF-kB trajectory - Nature
• Atrial Natriuretic Peptide Inhibited ABCA1/G1-dependent Cholesterol Efflux Related to Low HDL-C in Hypertensive Pregnant Patients - Frontiers
• PMP22 Regulates Cholesterol Trafficking and ABCA1-Mediated Cholesterol Efflux - Journal of Neuroscience
• CCAAT/Enhancer-binding protein delta mediates glioma stem-like cell enrichment and ATP-binding cassette transporter ABCA1 activation for temozolomide resistance in glioblastoma - Nature
• Protective role of ABCA1 in ischemic preconditioning is mediated by downregulation of miR-33-5p and miR-135-5p - Nature
• USC-led study finds potential new drug target for Alzheimer’s disease - Keck School of Medicine of USC
• Deletion of miR-33, a regulator of the ABCA1–APOE pathway, ameliorates neuropathological phenotypes in APP/PS1 mice - Wiley
• ApoE4 Alters ABCA1 Membrane Trafficking in Astrocytes - Journal of Neuroscience
• V-ATPase (Vacuolar ATPase) Activity Required for ABCA1 (ATP-Binding Cassette Protein A1)-Mediated Cholesterol Efflux | Arteriosclerosis, Thrombosis, and Vascular Biology - American Heart Association Journals
• Pro-apoptotic miRNA-128-2 modulates ABCA1, ABCG1 and RXRα expression and cholesterol homeostasis - Nature
• ABCA1 69C>T Polymorphism and the Risk of Type 2 Diabetes Mellitus: A Systematic Review and Updated Meta-Analysis - Frontiers
• Ferredoxin reductase and p53 are necessary for lipid homeostasis and tumor suppression through the ABCA1–SREBP pathway - Nature
• T cell cholesterol efflux suppresses apoptosis and senescence and increases atherosclerosis in middle aged mice - Nature
• Dickkopf-1 promotes vascular smooth muscle cell foam cell formation and atherosclerosis development through CYP4A11/SREBP2/ABCA1 - Wiley
• Identification of a novel cholesterol-lowering dipeptide, phenylalanine-proline (FP), and its down-regulation of intestinal ABCA1 in hypercholesterolemic rats and Caco-2 cells - Nature
• Small HDL Promotes Cholesterol Efflux by the ABCA1 Pathway in Macrophages: - American Heart Association Journals
• ABCA1 mRNA and Protein Distribution Patterns Predict Multiple Different Roles and Levels of Regulation - Nature
• An iPSC-derived astrocyte model of fragile X syndrome exhibits dysregulated cholesterol homeostasis - Nature
• PPAR-α and PPAR-γ activators induce cholesterol removal from human macrophage foam cells through stimulation of the ABCA1 pathway - Nature
• Common variants near ABCA1 AFAP1 and GMDS confer risk of primary open-angle glaucoma - Nature
• The ATP-binding cassette transporter A1 regulates phosphoantigen release and Vγ9Vδ2 T cell activation by dendritic cells - Nature
• MicroRNA-148a regulates LDL receptor and ABCA1 expression to control circulating lipoprotein levels - Nature
• Tumour-associated macrophage-derived DOCK7-enriched extracellular vesicles drive tumour metastasis in colorectal cancer via the RAC1/ABCA1 axis - Wiley Online Library
• High glucose, unsaturated and saturated fatty acids differentially regulate expression of ATP-binding cassette transporters ABCA1 and ABCG1 in human macrophages - Nature
• Common variants near ABCA1 and in PMM2 are associated with primary open-angle glaucoma - Nature
• Maternal ABCA1 genotype is associated with severity of Smith–Lemli–Opitz syndrome and with viability of patients homozygous for null mutations - Nature
• High glucose upregulates BACE1-mediated Aβ production through ROS-dependent HIF-1α and LXRα/ABCA1-regulated lipid raft reorganization in SK-N-MC cells - Nature
• β-cell ABCA1 influences insulin secretion, glucose homeostasis and response to thiazolidinedione treatment - Nature
• A new role for lncRNAs in atherosclerosis - Nature
• ABC Transporters and the Alzheimer’s Disease Enigma - Frontiers
• The effect of ABCA1 gene DNA methylation on blood pressure levels in a Chinese hyperlipidemic population - Nature
• Control of cellular cholesterol efflux by the nuclear oxysterol receptor LXRα - PNAS
• Cholesterol Efflux-Independent Modification of Lipid Rafts by AIBP (Apolipoprotein A-I Binding Protein) - American Heart Association Journals
• How two key proteins orchestrate flip-flopping cholesterol in the cell membrane - Phys.org
• With No Treatment for Tangier Disease, Management Focuses on Preventing Atherosclerosis - AJMC
• Elder ( Sambucus nigra ), identified by high-content screening, counteracts foam cell formation without promoting hepatic lipogenesis - Nature
• Changes in the asymmetric distribution of cholesterol in the plasma membrane influence streptolysin O pore formation - Nature
• Gut Microbially Produced Indole-3-Propionic Acid Inhibits Atherosclerosis by Promoting Reverse Cholesterol Transport and Its Deficiency Is Causally Related to Atherosclerotic Cardiovascular Disease - American Heart Association Journals
• Clemson researchers tackle atherosclerosis – the ‘silent killer’ - Clemson News
• DMSO - Dove Medical Press
• Integration of methylation quantitative trait loci (mQTL) on dietary intake on DNA methylation levels: an example of n-3 PUFA and ABCA1 gene - Nature
• miR-33 links SREBP-2 induction to repression of sterol transporters - PNAS
• Adipocyte Membrane Cholesterol Regulates Obesity - American Heart Association Journals
• Small HDL particles in brain appear protective against Alzheimer’s disease - Healio
• Probucol increased the targeting of mitochondria to lysosomes through ABCA1. - PLOS
• Pathways and Mechanisms of Cellular Cholesterol Efflux—Insight From Imaging - Frontiers
• Nascent HDL (High-Density Lipoprotein) Discs Carry Cholesterol to HDL Spheres: - American Heart Association Journals
• ATP-binding cassette transporter-2 (ABCA2) as a therapeutic target - ScienceDirect.com
• Mendelian randomization reveals probucol’s preventive role in Behçet’s disease via circulating metabolites - Nature