Why is "ACTN2" trending?

Search Interest Perspective

• Molecular Duet at the Z-Disc: How α-Actinin-4 Fine Tunes Cardiac Contraction - American Heart Association Journals
• Protein-extending ACTN2 frameshift variants cause variable myopathy phenotypes by protein aggregation - Wiley Online Library
• Genome-wide association and multi-omic analyses reveal ACTN2 as a gene linked to heart failure - nature.com
• Characterization and Function of the Interaction of Angiogenin With Alpha-Actinin 2 - Frontiers
• Structural and functional insights into α-actinin isoforms and their implications in cardiovascular disease - Rockefeller University Press
• Cardiac ACTN2 enhancer regulates cardiometabolism and maturation - nature.com
• Researchers develop promising stem cell-based regenerative therapy for heart disease - Medical Xpress
• Molecular autopsy and clinical family screening in a case of sudden cardiac death reveals ACTN2 mutation related to hypertrophic/dilated cardiomyopathy and a novel LZTR1 variant associated with Noonan syndrome - Wiley Online Library
• Alternative Splicing Mediated by RNA-Binding Protein RBM24 Facilitates Cardiac Myofibrillogenesis in a Differentiation Stage-Specific Manner - American Heart Association Journals
• Calcium modulates the domain flexibility and function of an α-actinin similar to the ancestral α-actinin - PNAS
• Structural and signaling proteins in the Z-disk and their role in cardiomyopathies - Frontiers
• Efficient and reproducible generation of human iPSC-derived cardiomyocytes and cardiac organoids in stirred suspension systems - nature.com
• Age-related mitochondrial alterations in brain and skeletal muscle of the YAC128 model of Huntington disease - nature.com
• Cardiac manifestations of human ACTA2 variants recapitulated in a zebrafish model - nature.com
• Identification of novel genetic variants associated with feline cardiomyopathy using targeted next-generation sequencing - nature.com
• QKI is a critical pre-mRNA alternative splicing regulator of cardiac myofibrillogenesis and contractile function - nature.com
• Single-cell transcriptomics in MI identify Slc25a4 as a new modulator of mitochondrial malfunction and apoptosis-associated cardiomyocyte subcluster - nature.com
• Data mining on identifying diagnosis and prognosis biomarkers in head and neck squamous carcinoma - nature.com
• Therapeutic efficacy of AAV-mediated restoration of PKP2 in arrhythmogenic cardiomyopathy - nature.com
• Affimers targeting proteins in the cardiomyocyte Z-disc: Novel tools that improve imaging of heart tissue - Frontiers
• SARS-CoV-2 infection of human iPSC–derived cardiac cells reflects cytopathic features in hearts of patients with COVID-19 - Science | AAAS
• Single-cell RNA sequencing of murine hearts for studying the development of the cardiac conduction system - nature.com
• Genome-wide association analyses of physical activity and sedentary behavior provide insights into underlying mechanisms and roles in disease prevention - nature.com
• Core Transcription Factors, MicroRNAs, and Small Molecules Drive Transdifferentiation of Human Fibroblasts Towards The Cardiac Cell Lineage - nature.com
• Microskeletal stiffness promotes aortic aneurysm by sustaining pathological vascular smooth muscle cell mechanosensation via Piezo1 - nature.com
• CMYA5 establishes cardiac dyad architecture and positioning - nature.com
• Alterations in the host transcriptome in vitro following Rift Valley fever virus infection - nature.com
• A step toward precision medicine: New drug targets for heart failure - News-Medical
• Gene Therapy Improves Heart Function in Hypertrophic Cardiomyopathy - Deutsches Zentrum für Herz-Kreislauf-Forschung