Why is "ADP-ribose" trending?
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- Date: 2026-03-27 02:49:35
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Wikipedia Overview
Adenosine diphosphate ribose (ADPR) is an ester molecule formed into chains by the enzyme poly ADP ribose polymerase. ADPR is created from cyclic ADP-ribose (cADPR) by the CD38 enzyme using nicotinamide adenine dinucleotide (NAD+) as a cofactor.
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Search Interest Perspective
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The rise of ADP-ribose–ubiquitin - Nature
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Deltex and RING-UIM E3 ligases cooperate to create a ubiquitin-ADP-ribose hybrid mark on tankyrase, promoting its stabilization - Science | AAAS
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Elevated TRIM25 Impairs Poly (ADP-ribose) Metabolism via PARG Degradation and Mediates Compression-Induced Intervertebral Disc Degeneration - Wiley
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A ribosomally synthesized and posttranslationally modified peptide with ADP-ribosylation - PNAS
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An evaluation of high-field asymmetric-waveform ion mobility spectrometry coupled to electron-transfer/higher-energy collision dissociation for ADP-ribosylation proteomics - Frontiers
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Global remodeling of ADP-ribosylation by PARP1 suppresses influenza A virus infection - Nature
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AcrIF11 is a potent CRISPR-specific ADP-ribosyltransferase encoded by phage and plasmid - ASM Journals
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Synthesis of Structural ADP-Ribose Analogues as Inhibitors for SARS-CoV-2 Macrodomain 1 - ACS Publications
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Poly(ADP-ribose) polymerase 1 orchestrates vascular smooth muscle cell homeostasis in arterial disease - Nature
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Synthesis of Bispecific Conjugates by ADP‐Ribosyl Cyclases - Wiley
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Cyclic ADP ribose isomers: Production, chemical structures, and immune signaling - Science | AAAS
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Identification of RNF114 as ADPr-Ub reader through non-hydrolysable ubiquitinated ADP-ribose - Nature
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Poly (ADP-Ribose) Glycohydrolase-Dependent dePARylation of PCNA Is Essential for DNA Replication - Wiley
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Targeted DNA ADP-ribosylation triggers templated repair in bacteria and base mutagenesis in eukaryotes - Nature
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Cardiomyocyte mitochondrial mono-ADP-ribosylation dictates cardiac tolerance to sepsis by configuring bioenergetic reserve in male mice - Nature
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Serine ADPr on histones and PARP1 is a cellular target of ester-linked ubiquitylation - Nature
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A versatile platform for chemical engineering of exosomes empowered by ADP-ribosyl cyclases - Nature
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Cation-induced intramolecular coil-to-globule transition in poly(ADP-ribose) - Nature
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Preserving ester-linked modifications reveals glutamate and aspartate mono-ADP-ribosylation by PARP1 and its reversal by PARG - Nature
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Mono-ADP-ribosylation, a MARylationmultifaced modification of protein, DNA and RNA: characterizations, functions and mechanisms - Nature
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CHD6 has poly(ADP-ribose)- and DNA-binding domains and regulates PARP1/2-trapping inhibitor sensitivity via abasic site repair - Nature
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Mechanistic insights into the three steps of poly(ADP-ribosylation) reversal - Nature
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Engineering Af1521 improves ADP-ribose binding and identification of ADP-ribosylated proteins - Nature
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Regulation of stress granule maturation and dynamics by poly(ADP-ribose) interaction with PARP13 - Nature
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Poly(ADP-ribose) binding sites on collagen I fibrils for nucleating intrafibrillar bone mineral - PNAS
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Poly(ADP-ribose) polymerase inhibition: past, present and future - Nature
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CRISPR screens and quantitative proteomics reveal remodeling of the aryl hydrocarbon receptor–driven proteome through PARP7 activity - PNAS
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Deregulated DNA ADP-ribosylation impairs telomere replication - Nature
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Cooperative nucleic acid binding by Poly ADP-ribose polymerase 1 - Nature
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Pathogenic ARH3 mutations result in ADP-ribose chromatin scars during DNA strand break repair - Nature
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Poly(ADP-ribose): novel functions for an old molecule - Nature
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Poly(ADP-ribose) drives pathologic α-synuclein neurodegeneration in Parkinson’s disease - Science | AAAS
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Targeting Poly(ADP)ribose polymerase in BCR/ABL1-positive cells - Nature
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Mechanism of threonine ADP-ribosylation of F-actin by a Tc toxin - Nature
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Family-wide analysis of poly(ADP-ribose) polymerase activity - Nature
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MacroGreen, a simple tool for detection of ADP-ribosylated proteins - Nature
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Poly(ADP-ribose) Polymerase 1 (PARP1) restrains MyoD-dependent gene expression during muscle differentiation - Nature
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Effects of poly (ADP-ribose) polymerase inhibitor treatment on the repair process of ischemic acute kidney injury - Nature
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Poly(ADP-ribose) polymerase-1 antagonizes DNA resection at double-strand breaks - Nature
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DELTEX E3 ligases ubiquitylate ADP-ribosyl modification on protein substrates - Science | AAAS
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Structural analyses of NudT16–ADP-ribose complexes direct rational design of mutants with improved processing of poly(ADP-ribosyl)ated proteins - Nature
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PARP1-produced poly-ADP-ribose causes the PARP12 translocation to stress granules and impairment of Golgi complex functions - Nature
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PARG is essential for Polθ-mediated DNA end-joining by removing repressive poly-ADP-ribose marks - Nature
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A novel 18F-labeled brain penetrant PET ligand for imaging poly(ADP-ribose) polymerase-1 - Journal of Nuclear Medicine
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Legionella metaeffector MavL reverses ubiquitin ADP-ribosylation via a conserved arginine-specific macrodomain - Nature
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Structural basis for nicotinamide cleavage and ADP-ribose transfer by NAD - PNAS
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signaling is essential for hepatic gluconeogenesis in fasting and diabetes - Nature
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Oncogenic activity of poly (ADP-ribose) glycohydrolase - Nature
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Caspase-7 uses an exosite to promote poly(ADP ribose) polymerase 1 proteolysis - PNAS
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Identification of regulators of poly-ADP-ribose polymerase inhibitor response through complementary CRISPR knockout and activation screens - Nature
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Poly(ADP) ribose polymerase promotes DNA polymerase theta-mediated end joining by activation of end resection - Nature
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Poly(ADP-ribose) glycohydrolase coordinates meiotic DNA double-strand break induction and repair independent of its catalytic activity - Nature
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Nudix hydrolases degrade protein-conjugated ADP-ribose - Nature
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Architecture of the TRPM2 channel and its activation mechanism by ADP-ribose and calcium - Nature
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Liquid demixing of intrinsically disordered proteins is seeded by poly(ADP-ribose) - Nature
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Poly(ADP-ribose)-binding protein RCD1 is a plant PARylation reader regulated by Photoregulatory Protein Kinases - Nature
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Does Cyclic ADP-Ribose (cADPR) Activate the Non-selective Cation Channel TRPM2? - Frontiers
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Functional Roles of Poly(ADP-Ribose) in Stress Granule Formation and Dynamics - Frontiers
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with unexpected high activity and selectivity for protein poly-ADP-ribosylation - Nature
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Mitochondrial damage elicits a TCDD-inducible poly(ADP-ribose) polymerase-mediated antiviral response - PNAS
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Identification of poly(ADP-ribose) polymerase 9 (PARP9) as a noncanonical sensor for RNA virus in dendritic cells - Nature
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Visualization of poly(ADP-ribose) bound to PARG reveals inherent balance between exo - and endo -glycohydrolase activities - Nature
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Structural and Biochemical Characterization of Poly-ADP-ribose Polymerase from Trypanosoma brucei - Nature
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The oligonucleotide/oligosaccharide-binding fold motif is a poly(ADP-ribose)-binding domain that mediates DNA damage response - PNAS
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Poly(ADP-ribose) polymerase 1 in genome-wide expression control in Drosophila - Nature
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Virus–Host Interplay Between Poly (ADP-Ribose) Polymerase 1 and Oncogenic Gammaherpesviruses - Frontiers
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Flap endonuclease 1 repairs DNA-protein cross-links via ADP-ribosylation–dependent mechanisms - Science | AAAS
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Update on poly(ADP-ribose) polymerase inhibitors resistance in ovarian cancer - Frontiers
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The structure and catalytic mechanism of a poly(ADP-ribose) glycohydrolase - Nature
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Poly(ADP-ribose) polymerase 1 accelerates vascular calcification by upregulating Runx2 - Nature
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Inhibition of Poly(ADP-Ribose) Polymerase in Tumors from BRCA Mutation Carriers - The New England Journal of Medicine
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Structural and biochemical evidence supporting poly ADP-ribosylation in the bacterium Deinococcus radiodurans - Nature
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ADP-ribosyl-acceptor hydrolase 3 regulates poly (ADP-ribose) degradation and cell death during oxidative stress - PNAS
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Barrier-to-autointegration factor 1 (Banf1) regulates poly [ADP-ribose] polymerase 1 (PARP1) activity following oxidative DNA damage - Nature
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Genomic and biological aspects of resistance to selective poly(ADP-ribose) glycohydrolase inhibitor PDD00017273 in human colorectal cancer cells - Wiley Online Library
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Histone ADP-ribosylation promotes resistance to PARP inhibitors by facilitating PARP1 release from DNA lesions - PNAS
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Mediation of Poly(ADP-Ribose) Polymerase-1-Dependent Cell Death by Apoptosis-Inducing Factor - Science | AAAS
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New insights into the molecular and cellular functions of poly(ADP-ribose) and PARPs - Nature
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Poly(ADP-ribose) (PAR) polymer is a death signal - PNAS
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ADP-ribose–derived nuclear ATP synthesis by NUDIX5 is required for chromatin remodeling - Science | AAAS
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Emerging roles of eraser enzymes in the dynamic control of protein ADP-ribosylation - Nature
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The structure of ADP-ribose pyrophosphatase reveals the structural basis for the versatility of the Nudix family - Nature
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Chromatin Loosening by Poly(ADP)-Ribose Polymerase (PARP) at Drosophila Puff Loci - Science | AAAS
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Molecular basis for DarT ADP-ribosylation of a DNA base - Nature
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Serine ADP-ribosylation in Drosophila provides insights into the evolution of reversible ADP-ribosylation signalling - Nature
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Poly(ADP-Ribose)Polymerase-1 in Lung Inflammatory Disorders: A Review - Frontiers
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The dual action of poly(ADP-ribose) polymerase -1 (PARP-1) inhibition in HIV-1 infection: HIV-1 LTR inhibition and diminution in Rho GTPase activity - Frontiers
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A nuclease that mediates cell death induced by DNA damage and poly(ADP-ribose) polymerase-1 - Science | AAAS
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Structure and mechanism of a canonical poly(ADP-ribose) glycohydrolase - Nature
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Doxorubicin-induced necrosis is mediated by poly-(ADP-ribose) polymerase 1 (PARP1) but is independent of p53 - Nature
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Response : Nitric Oxide Toxicity and Poly(ADP-Ribose)Polymerase - Science | AAAS
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Update on Poly ADP-Ribose Polymerase Inhibitors in Ovarian Cancer With Non-BRCA Mutations - Frontiers
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ADP-ribosylation promotes transcription elongation - Nature
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Loss of poly(ADP-ribose) glycohydrolase causes progressive neurodegeneration in Drosophila melanogaster - PNAS
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PARPs and ADP-Ribosylation: 50 Years … and Counting - ScienceDirect.com
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A chromatin localization screen reveals poly (ADP ribose)-regulated recruitment of the repressive polycomb and NuRD complexes to sites of DNA damage - PNAS
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PARP14 is a PARP with both ADP-ribosyl transferase and hydrolase activities - Science | AAAS
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Mono-ADP-Ribosylation: A Tool for Modulating Immune Response and Cell Signaling - Science | AAAS
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Poly(ADP-ribose) mediates bioenergetic defects and redox imbalance in neurons following oxygen and glucose deprivation - Wiley
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Poly(ADP-ribosyl)ating enzymes cooperate to coordinate development - Nature
Why This Topic Is Trending
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