Why is "ADP-ribosylation" trending?
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Trend Analysis
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- Date: 2026-03-12 03:06:51
This topic has appeared in the trending rankings 1 time(s) in the past year. While it does not trend frequently, its appearance suggests a renewed or concentrated surge of public interest.
Based on Wikipedia pageviews and search interest, this topic gained significant attention on the selected date.
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Wikipedia Overview
ADP-ribosylation is the addition of one or more ADP-ribose moieties to a protein. It is a reversible post-translational modification that is involved in many cellular processes, including cell signaling, DNA repair, gene regulation and apoptosis.
Improper ADP-ribosylation has been implicated in some forms of cancer. It is also the basis for the toxicity of bacterial compounds such as cholera toxin, diphtheria toxin, and others.
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Trending Topic Today
Search Interest Perspective
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Global remodeling of ADP-ribosylation by PARP1 suppresses influenza A virus infection - Nature
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A ribosomally synthesized and posttranslationally modified peptide with ADP-ribosylation - PNAS
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ADP-Ribosylation in Experimental Atherosclerosis: A Potential Link Between Dyslipidemia and Inflammation in Cardiovascular Disease - American Heart Association Journals
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An evaluation of high-field asymmetric-waveform ion mobility spectrometry coupled to electron-transfer/higher-energy collision dissociation for ADP-ribosylation proteomics - Frontiers
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AcrIF11 is a potent CRISPR-specific ADP-ribosyltransferase encoded by phage and plasmid - ASM Journals
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Targeted DNA ADP-ribosylation triggers templated repair in bacteria and base mutagenesis in eukaryotes - Nature
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Deltex and RING-UIM E3 ligases cooperate to create a ubiquitin-ADP-ribose hybrid mark on tankyrase, promoting its stabilization - Science | AAAS
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Elevated TRIM25 Impairs Poly (ADP-ribose) Metabolism via PARG Degradation and Mediates Compression-Induced Intervertebral Disc Degeneration - Wiley
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A ribosomally synthesized and posttranslationally modified peptide with ADP-ribosylation - PNAS
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Versatile and sensitive detection of mono- and poly(ADP-ribosyl)ation reveals XRCC1-dependent remodelling of PARP1 signalling - Nature
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ADP-Ribosylation in Experimental Atherosclerosis: A Potential Link Between Dyslipidemia and Inflammation in Cardiovascular Disease - American Heart Association Journals
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PARP14 is an interferon-induced host factor that promotes IFN production and affects the replication of multiple viruses - ASM Journals
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PARP12-mediated mono-ADP-ribosylation as a checkpoint for necroptosis and apoptosis - PNAS
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PARP1-HPF1 structure and dynamics on nicked DNA suggest a mechanism for acute and localized ADP-ribosylation - Nature
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Cardiomyocyte mitochondrial mono-ADP-ribosylation dictates cardiac tolerance to sepsis by configuring bioenergetic reserve in male mice - Nature
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Regulation of ADP-ribosyltransferase activity by ART domain dimerization in PARP15 - Nature
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Serine ADPr on histones and PARP1 is a cellular target of ester-linked ubiquitylation - Nature
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Single nucleosome imaging reveals principles of transient multiscale chromatin reorganization triggered by histone ADP-ribosylation at DNA lesions - Nature
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Identification of RNF114 as ADPr-Ub reader through non-hydrolysable ubiquitinated ADP-ribose - Nature
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The rise of ADP-ribose–ubiquitin - Nature
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Discovery of Inhibitors for Bacterial Arr Enzymes ADP-Ribosylating and Inactivating Rifamycin Antibiotics - ACS Publications
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Poly (ADP-Ribose) Glycohydrolase-Dependent dePARylation of PCNA Is Essential for DNA Replication - Wiley
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Deregulated DNA ADP-ribosylation impairs telomere replication - Nature
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Preserving ester-linked modifications reveals glutamate and aspartate mono-ADP-ribosylation by PARP1 and its reversal by PARG - Nature
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A repurposed AMP binding domain reveals mitochondrial protein AMPylation as a regulator of cellular metabolism - Nature
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Mono-ADP-ribosylation, a MARylationmultifaced modification of protein, DNA and RNA: characterizations, functions and mechanisms - Nature
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Mechanism of threonine ADP-ribosylation of F-actin by a Tc toxin - Nature
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Serine ADP-ribosylation in Drosophila provides insights into the evolution of reversible ADP-ribosylation signalling - Nature
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Molecular basis for DarT ADP-ribosylation of a DNA base - Nature
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Mechanistic insights into the three steps of poly(ADP-ribosylation) reversal - Nature
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A viral ADP-ribosyltransferase attaches RNA chains to host proteins - Nature
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Legionella metaeffector MavL reverses ubiquitin ADP-ribosylation via a conserved arginine-specific macrodomain - Nature
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Anti-viral defence by an mRNA ADP-ribosyltransferase that blocks translation - Nature
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MacroGreen, a simple tool for detection of ADP-ribosylated proteins - Nature
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Histone ADP-ribosylation promotes resistance to PARP inhibitors by facilitating PARP1 release from DNA lesions - PNAS
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Flap endonuclease 1 repairs DNA-protein cross-links via ADP-ribosylation–dependent mechanisms - Science | AAAS
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Interplay between ADP-ribosyltransferases and essential cell signaling pathways controls cellular responses - Nature
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-dependent poly ADP-ribosylation of mitochondrial nucleoids - Nature
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Androgen signaling uses a writer and a reader of ADP-ribosylation to regulate protein complex assembly - Nature
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Emerging roles of eraser enzymes in the dynamic control of protein ADP-ribosylation - Nature
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Molecular basis of threonine ADP-ribosylation of ubiquitin by bacterial ARTs - Nature
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Regulation of Rad52-dependent replication fork recovery through serine ADP-ribosylation of PolD3 - Nature
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Truncated PARP1 mediates ADP-ribosylation of RNA polymerase III for apoptosis - Nature
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Poly(ADP-ribosylation) of P-TEFb by PARP1 disrupts phase separation to inhibit global transcription after DNA damage - Nature
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HPF1 completes the PARP active site for DNA damage-induced ADP-ribosylation - Nature
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Structural and biochemical evidence supporting poly ADP-ribosylation in the bacterium Deinococcus radiodurans - Nature
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Proteome-wide identification of the endogenous ADP-ribosylome of mammalian cells and tissue - Nature
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PARP2 mediates branched poly ADP-ribosylation in response to DNA damage - Nature
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Zinc-finger PARP proteins ADP-ribosylate alphaviral proteins and are required for interferon-γ–mediated antiviral immunity - Science | AAAS
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PARP9 and PARP14 cross-regulate macrophage activation via STAT1 ADP-ribosylation - Nature
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Biomimetic α-selective ribosylation enables two-step modular synthesis of biologically important ADP-ribosylated peptides - Nature
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Structural insights into ADP-ribosylation of ubiquitin by Deltex family E3 ubiquitin ligases - Science | AAAS
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Insights into the biogenesis, function, and regulation of ADP-ribosylation - Nature
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Cell-Permeable Nicotinamide Adenine Dinucleotides for Exploration of Cellular Protein ADP-Ribosylation - Wiley Online Library
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Poly ADP ribosylation and extracellular vesicle activity in rod photoreceptor degeneration - Nature
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PARPs and ADP-Ribosylation: 50 Years … and Counting - ScienceDirect.com
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An Integrated Chemical Proteomics Approach for Quantitative Profiling of Intracellular ADP-Ribosylation - Nature
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Engineering Af1521 improves ADP-ribose binding and identification of ADP-ribosylated proteins - Nature
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Neuralized-like protein 4 (NEURL4) mediates ADP-ribosylation of mitochondrial proteins - Rockefeller University Press
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SirT7 auto-ADP-ribosylation regulates glucose starvation response through mH2A1 - Science | AAAS
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Nuclear ADP-ribosylation drives IFNγ-dependent STAT1α enhancer formation in macrophages - Nature
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Regulation of stress granule maturation and dynamics by poly(ADP-ribose) interaction with PARP13 - Nature
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with unexpected high activity and selectivity for protein poly-ADP-ribosylation - Nature
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Linking DNA repair and cell cycle progression through serine ADP-ribosylation of histones - Nature
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Poly ADP-ribosylation of SET8 leads to aberrant H4K20 methylation in mammalian nuclear genome - Nature
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HPF1 remodels the active site of PARP1 to enable the serine ADP-ribosylation of histones - Nature
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Cooperative nucleic acid binding by Poly ADP-ribose polymerase 1 - Nature
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Chemical O‐ADP‐Ribosylations: Synthesis and Bioconjugation of ADPr‐Peptides/Proteins from NAD+ - Wiley Online Library
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PARP14 is a PARP with both ADP-ribosyl transferase and hydrolase activities - Science | AAAS
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DELTEX E3 ligases ubiquitylate ADP-ribosyl modification on protein substrates - Science | AAAS
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Poly(ADP-ribose) polymerase inhibition: past, present and future - Nature
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Wnt pathway activation by ADP-ribosylation - Nature
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Serine is a new target residue for endogenous ADP-ribosylation on histones - Nature
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On the role of STAT1 and STAT6 ADP-ribosylation in the regulation of macrophage activation - Nature
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Mono-ADP-Ribosylation: A Tool for Modulating Immune Response and Cell Signaling - Science | AAAS
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The Making and Breaking of Serine-ADP-Ribosylation in the DNA Damage Response - Frontiers
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Cytoplasmic ADP-ribosylation levels correlate with markers of patient outcome in distinct human cancers - Nature
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Family-wide analysis of poly(ADP-ribose) polymerase activity - Nature
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Redesign of Rifamycin Antibiotics to Overcome ADP‐Ribosylation‐Mediated Resistance - Wiley Online Library
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Expression of the mono-ADP-ribosyltransferase ART1 by tumor cells mediates immune resistance in non–small cell lung cancer - Science | AAAS
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Poly-ADP-ribosylation-mediated degradation of ARTD1 by the NLRP3 inflammasome is a prerequisite for osteoclast maturation - Nature
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ADP-ribosylating and vacuolating cytotoxin of Mycoplasma pneumoniae represents unique virulence determinant among bacterial pathogens - PNAS
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Site-specific ADP-ribosylation of histone H2B in response to DNA double strand breaks - Nature
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Characterization of pertussis-like toxin from Salmonella spp. that catalyzes ADP-ribosylation of G proteins - Nature
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The risky business of ADP-ribosylating telomeric DNA - Nature
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A family of macrodomain proteins reverses cellular mono-ADP-ribosylation - Nature
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ADP-ribosylation promotes transcription elongation - Nature
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Synthesis of Structural ADP-Ribose Analogues as Inhibitors for SARS-CoV-2 Macrodomain 1 - ACS Publications
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PARP1-produced poly-ADP-ribose causes the PARP12 translocation to stress granules and impairment of Golgi complex functions - Nature
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Rhodopsin C terminus, the site of mutations causing retinal disease, regulates trafficking by binding to ADP-ribosylation factor 4 (ARF4) - PNAS
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Poly(ADP-ribose)-binding protein RCD1 is a plant PARylation reader regulated by Photoregulatory Protein Kinases - Nature
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Chemical O‐ADP‐Ribosylations: Synthesis and Bioconjugation of ADPr‐Peptides/Proteins from NAD+ - Wiley Online Library
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Reversible modification of mitochondrial ADP/ATP translocases by paired Legionella effector proteins - PNAS
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Virus–Host Interplay Between Poly (ADP-Ribose) Polymerase 1 and Oncogenic Gammaherpesviruses - Frontiers
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ADP-Ribosylation Factor-Like 2 (ARL2) regulates cilia stability and development of outer segments in rod photoreceptor neurons - Nature
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Poly(ADP-ribose) glycohydrolase coordinates meiotic DNA double-strand break induction and repair independent of its catalytic activity - Nature
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Cis- and trans- resveratrol have opposite effects on histone serine-ADP-ribosylation and tyrosine induced neurodegeneration - Nature
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Chemical proteomics reveals ADP-ribosylation of small GTPases during oxidative stress - Nature
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Progress in the Function and Regulation of ADP-Ribosylation - Science | AAAS
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ADP-ribosyl-acceptor hydrolase 3 regulates poly (ADP-ribose) degradation and cell death during oxidative stress - PNAS
Why This Topic Is Trending
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Search interest data over the past 12 months indicates that this topic periodically attracts global attention. Sudden spikes often correlate with major news events, public statements, or geopolitical developments.