Why is "AMP-activated protein kinase" trending?
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- Date: 2026-03-13 13:34:44
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Wikipedia Overview
5' AMP-activated protein kinase or AMPK or 5' adenosine monophosphate-activated protein kinase is an enzyme that plays a role in cellular energy homeostasis, largely to activate glucose and fatty acid uptake and oxidation when cellular energy is low. It belongs to a highly conserved eukaryotic protein family and its orthologues are SNF1 in yeast, and SnRK1 in plants. It consists of three proteins (subunits) that together make a functional enzyme, conserved from yeast to humans. It is expressed in a number of tissues, including the liver, brain, and skeletal muscle. In response to binding AMP and ADP, the net effect of AMPK activation is stimulation of hepatic fatty acid oxidation, ketogenesis, stimulation of skeletal muscle fatty acid oxidation and glucose uptake, inhibition of cholesterol synthesis, lipogenesis, and triglyceride synthesis, inhibition of adipocyte lipogenesis, inhibition of adipocyte lipolysis, and modulation of insulin secretion by pancreatic β-cells.
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Search Interest Perspective
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AMP-activated protein kinase-driven lipid droplet dynamics govern melanoma sensitivity to polyunsaturated fatty acid and iron-induced ferroptosis - Nature
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Targeting the AMP-activated protein kinase pathway: the active metabolites of botanical drugs represent potential strategies for treating metabolic-associated fatty liver disease - Frontiers
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The Role of Mammalian Target of Rapamycin (mTOR) and Adenosine Monophosphate-Activated Protein Kinase (AMPK) Signaling in Skeletal Muscle Hypertrophy: A Literature Review With Implications for Health and Disease - Cureus
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1,1-Diethoxyethane enhances aerobic respiration in human mitochondria via activation of AMP-activated protein kinase - Nature
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Targeting the AMP-activated protein kinase pathway: the active metabolites of botanical drugs represent potential strategies for treating metabolic-associated fatty liver disease - Frontiers
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AMP-activated protein kinase (AMPK) action in skeletal muscle via direct phosphorylation of PGC-1α - pnas.org
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Statins Activate AMP-Activated Protein Kinase In Vitro and In Vivo - American Heart Association Journals
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Isoform-specific roles of AMP-activated protein kinase in cardiac physiology and pathophysiology - Frontiers
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Advanced glycation end products exacerbate lipopolysaccharide-induced acute lung injury with diabetes by promoting ferroptosis via AMP-activated protein kinase/acetyl-CoA carboxylase signaling - Nature
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AMP-activated protein kinase adapts rRNA synthesis to cellular energy supply - pnas.org
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AMP-Activated Protein Kinase γ2 to the Rescue in Ischemic Heart | Circulation Research - American Heart Association Journals
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Bioactives and exercise synergize to modulate AMPK and inflammation - Frontiers
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AMP-activated protein kinase: the current landscape for drug development - Nature
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Targeting AMP-activated protein kinase in sepsis - Frontiers
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Rapid metabolic reprogramming mediated by the AMP-activated protein kinase during the lytic cycle of Toxoplasma gondii - Nature
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AMP-Activated Protein Kinase and O-GlcNAcylation, Two Partners Tightly Connected to Regulate Key Cellular Processes - Frontiers
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Involvement of AMP-activated Protein Kinase (AMPK) in Regulation of Cell Membrane Potential in a Gastric Cancer Cell Line - Nature
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Roles of AMP-Activated Protein Kinase (AMPK) in Mammalian Reproduction - Frontiers
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AMP-activated protein kinase modulates tau phosphorylation and tau pathology in vivo - Nature
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An AMP-activated protein kinase–stabilizing peptide ameliorates adipose tissue wasting in cancer cachexia in mice - Nature
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AMP-activated protein kinase: nature's energy sensor - Nature
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Metformin: Activation of 5′ AMP-activated protein kinase and its emerging potential beyond anti-hyperglycemic action - Frontiers
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Activation of yeast Snf1 and mammalian AMP-activated protein kinase by upstream kinases - pnas.org
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Molecular Mechanisms of Adipogenesis: The Anti-adipogenic Role of AMP-Activated Protein Kinase - Frontiers
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inhibition stimulates AMP-activated protein kinase-mediated autophagy in colorectal cancer cells - Nature
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The role of AMP-activated protein kinase in the cardiovascular system - Nature
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Structural insight into the autoinhibition mechanism of AMP-activated protein kinase - Nature
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β-subunit myristoylation functions as an energy sensor by modulating the dynamics of AMP-activated Protein Kinase - Nature
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Activating AMP-activated protein kinase (AMPK) slows renal cystogenesis - pnas.org
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Impact of 5'-amp-activated Protein Kinase on Male Gonad and Spermatozoa Functions - Frontiers
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(ADP-ribose) polymerase 1 and AMP-activated protein kinase mediate progressive dopaminergic neuronal degeneration in a mouse model of Parkinson’s disease | Cell Death & Disease - Nature
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Structural basis for AMP binding to mammalian AMP-activated protein kinase - Nature
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A plant triterpenoid, avicin D, induces autophagy by activation of AMP-activated protein kinase - Nature
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Reduction of AMP-Activated Protein Kinase α2 Increases Endoplasmic Reticulum Stress and Atherosclerosis In Vivo - American Heart Association Journals
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Targeting the AMP-Activated Protein Kinase for Cancer Prevention and Therapy - Frontiers
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AMP-activated protein kinase is physiologically regulated by inositol polyphosphate multikinase - pnas.org
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HIV and Cocaine Impact Glial Metabolism: Energy Sensor AMP-activated protein kinase Role in Mitochondrial Biogenesis and Epigenetic Remodeling - Nature
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Human kinome profiling identifies a requirement for AMP-activated protein kinase during human cytomegalovirus infection - pnas.org
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AMP-activated protein kinase as a key molecular link between metabolism and clockwork - Nature
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Role of AMP-activated protein kinase in cross-talk between apoptosis and autophagy in human colon cancer - Nature
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Glucose-dependent regulation of pregnane X receptor is modulated by AMP-activated protein kinase - Nature
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AMP-Activated Protein Kinase Regulates Neuronal Polarization by Interfering with PI 3-Kinase Localization - Science | AAAS
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AMP-activated protein kinase activation in skeletal muscle modulates exercise-induced uncoupled protein 1 expression in brown adipocyte in mouse model - Wiley
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AMPK activators: mechanisms of action and physiological activities | Experimental & Molecular Medicine - Nature
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Salicylate induces epithelial actin reorganization via activation of the AMP-activated protein kinase and promotes wound healing and contraction in mice - Nature
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Interactome analysis of AMP-activated protein kinase (AMPK)-α1 and -β1 in INS-1 pancreatic beta-cells by affinity purification-mass spectrometry - Nature
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Soluble Uric Acid Promotes Atherosclerosis via AMPK (AMP-Activated Protein Kinase)-Mediated Inflammation - American Heart Association Journals
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Snf1/AMP-activated protein kinase activates Arf3p to promote invasive yeast growth via a non-canonical GEF domain - Nature
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AMP-activated protein kinase activation primes cytoplasmic translocation and autophagic degradation of the BCR-ABL protein in CML cells - onlinelibrary.wiley.com
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The microbial metabolite imidazole propionate dysregulates bone homeostasis by inhibiting AMP-activated protein kinase (AMPK) signaling - Nature
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AMP-activated protein kinase-α1 as an activating kinase of TGF-β-activated kinase 1 has a key role in inflammatory signals | Cell Death & Disease - Nature
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Activation of AMP-activated protein kinase stimulates the nuclear localization of glyceraldehyde 3-phosphate dehydrogenase in human diploid fibroblasts - Nature
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Bmf upregulation through the AMP-activated protein kinase pathway may protect the brain from seizure-induced cell death - Nature
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AMP-Activated Protein Kinase: - American Heart Association Journals
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Adiponectin stimulates glucose utilization and fatty-acid oxidation by activating AMP-activated protein kinase - Nature
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Deficiency of the hepatokine selenoprotein P increases responsiveness to exercise in mice through upregulation of reactive oxygen species and AMP-activated protein kinase in muscle - Nature
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Adiponectin protects the rats liver against chronic intermittent hypoxia induced injury through AMP-activated protein kinase pathway - Nature
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Energy-dependent regulation of cell structure by AMP-activated protein kinase - Nature
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New dammarane-type glucosides as potential activators of AMP-activated protein kinase (AMPK) from Gynostemma pentaphyllum - ScienceDirect.com
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Danthron activates AMP-activated protein kinase and regulates lipid and glucose metabolism in vitro - Nature
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Spatial regulation of AMPK signaling revealed by a sensitive kinase activity reporter - Nature
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What Athletes Should Know About AICAR and Others | USADA - usada.org
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Prognostic significance of AMP-activated protein kinase expression and modifying effect of MAPK3/1 in colorectal cancer - Nature
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Reduced Activity of AMP-Activated Protein Kinase Protects against Genetic Models of Motor Neuron Disease - Journal of Neuroscience
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Enhanced muscle fat oxidation and glucose transport by ACRP30 globular domain: Acetyl–CoA carboxylase inhibition and AMP-activated protein kinase activation - pnas.org
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Reduced Activity of AMP-Activated Protein Kinase Protects against Genetic Models of Motor Neuron Disease - Journal of Neuroscience
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The AMP-Activated Protein Kinase KIN10 Is Involved in the Regulation of Autophagy in Arabidopsis - Frontiers
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ATP-Induced Inflammasome Activation and Pyroptosis Is Regulated by AMP-Activated Protein Kinase in Macrophages - Frontiers
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Antiplatelet effect of AMP-activated protein kinase activator and its potentiation by the phosphodiesterase inhibitor dipyridamole - ScienceDirect.com
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Stimulation of glucose uptake by theasinensins through the AMP-activated protein kinase pathway in rat skeletal muscle cells - ScienceDirect.com
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AMP-activated protein kinase inhibition in fibro-adipogenic progenitors impairs muscle regeneration and increases fibrosis - onlinelibrary.wiley.com
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Fatal Infantile Cardiac Glycogenosis with Phosphorylase Kinase Deficiency and a Mutation in the γ2-Subunit of AMP-Activated Protein Kinase - Nature
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AMP kinase: A promising therapeutic drug target for post-COVID-19 complications - ScienceDirect.com
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Raspberry alleviates obesity-induced inflammation and insulin resistance in skeletal muscle through activation of AMP-activated protein kinase (AMPK) α1 - Nature
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Role of AMP‐Activated Protein Kinase in Cancer Therapy - Rehman - 2014 - Archiv der Pharmazie - onlinelibrary.wiley.com
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Evidence for a Cross-Talk Between Cytosolic 5′-Nucleotidases and AMP-Activated Protein Kinase - Frontiers
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The regulation of AMP-activated protein kinase by upstream kinases - Nature
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Pravastatin accelerates ischemia-induced angiogenesis through AMP-activated protein kinase - Nature
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AMP-activated protein kinase as regulator of P2Y6 receptor-induced insulin secretion in mouse pancreatic β-cells - ScienceDirect.com
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Stop Me at Your Own PeRiL: PRL2 Constrains AMPK in the Pressure-Overloaded Heart - American Heart Association Journals
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New research into AMP-activated protein kinase could make cancer treatments more efficient - Phys.org
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AMP-activated protein kinase and human cancer: cancer metabolism revisited - Nature
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Energy sensing by the AMP-activated protein kinase and its effects on muscle metabolism - Cambridge University Press & Assessment
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A High-Concentrate Diet Induced Milk Fat Decline via Glucagon-Mediated Activation of AMP-Activated Protein Kinase in Dairy Cows - Nature
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Treatment of Obese Zebrafish with Saringosterol Acetate through AMP Activated Protein Kinase Pathway - onlinelibrary.wiley.com
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Urocortin 2 autocrine/paracrine and pharmacologic effects to activate AMP-activated protein kinase in the heart - pnas.org
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Regulation of Glucose Transporter 3 Surface Expression by the AMP-Activated Protein Kinase Mediates Tolerance to Glutamate Excitation in Neurons - Journal of Neuroscience
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Anticancer effects of epigallocatechin-3-gallate nanoemulsion on lung cancer cells through the activation of AMP-activated protein kinase signaling pathway - Nature
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Metformin Prevents Progression of Heart Failure in Dogs | Circulation - American Heart Association Journals
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AMPK and Pulmonary Hypertension: Crossroads Between Vasoconstriction and Vascular Remodeling - Frontiers
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AMP-activated protein kinase control of energy metabolism in the ischemic heart - Nature
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Stop Me at Your Own PeRiL: PRL2 Constrains AMPK in the Pressure-Overloaded Heart - American Heart Association Journals
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Canagliflozin inhibits interleukin-1β-stimulated cytokine and chemokine secretion in vascular endothelial cells by AMP-activated protein kinase-dependent and -independent mechanisms - Nature
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Atrial Lesions in a Pedigree With PRKAG2 Cardiomyopathy: Involvement of Disrupted AMP-Activated Protein Kinase Signaling - Frontiers
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Catechin-induced activation of the LKB1/AMP-activated protein kinase pathway - ScienceDirect.com
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Chronic Glutathione Depletion Confers Protection against Alcohol-induced Steatosis: Implication for Redox Activation of AMP-activated Protein Kinase Pathway - Nature
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Natural products targeting AMPK signaling pathway therapy, diabetes mellitus and its complications - Frontiers
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Cucurbitacin B Induces Hypoglycemic Effect in Diabetic Mice by Regulation of AMP-Activated Protein Kinase Alpha and Glucagon-Like Peptide-1 via Bitter Taste Receptor Signaling - Frontiers
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Adiponectin enhances bone marrow mesenchymal stem cell resistance to flow shear stress through AMP-activated protein kinase signaling - Nature
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Regulation and function of AMPK in physiology and diseases - Nature
Why This Topic Is Trending
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Search interest data over the past 12 months indicates that this topic periodically attracts global attention. Sudden spikes often correlate with major news events, public statements, or geopolitical developments.