Why is "AMPA receptor" trending?
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- Date: 2026-03-11 09:49:14
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Wikipedia Overview
The α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor is an ionotropic glutamate receptor (iGluR) and predominantly sodium ion channel that mediates fast excitatory neurotransmission in the central nervous system (CNS). Its activation by the neurotransmitter glutamate facilitates rapid neuronal communication, essential for various brain functions, including learning and memory. Its name is derived from the ability to be activated by the artificial glutamate analog AMPA. The receptor was initially named the "quisqualate receptor" by Watkins and colleagues after the naturally occurring agonist quisqualate. Later, the receptor was designated as the "AMPA receptor" following the development of the selective agonist AMPA by Tage Honore and colleagues at the Royal Danish School of Pharmacy in Copenhagen. The GRIA2-encoded AMPA receptor ligand binding core was the first glutamate receptor ion channel domain to be crystallized.
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Search Interest Perspective
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AMPA Receptor Modulation Shows Promise in Major Depressive Disorder Treatment - HMP Global Learning Network
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GluA4 AMPA receptor gating mechanisms and modulation by auxiliary proteins - Nature
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Generalised Hodgkin–Huxley model captures human P2X and AMPA receptor currents - Wiley
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Clinical Characterization and Long-Term Outcome in Children and Adults With Anti-AMPA Receptor Encephalitis - Neurology® Journals
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First-in-Human Study of 18F-Labeled PET Tracer for Glutamate AMPA Receptor [18F]K-40: A Derivative of [11C]K-2 - Journal of Nuclear Medicine
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Dynamic extracellular interactions with AMPA receptors - PNAS
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New research sheds light on why brain fog is a common symptom of long COVID. - Psychology Today
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Augmenting AMPA receptor signaling after spinal cord injury increases ependymal-derived neural stem/progenitor cell migration and promotes functional recovery - Nature
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AMPA receptors in the evolving synapse: structure, function, and disease implications - Frontiers
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Correction to “Photobiomodulation Suppresses JNK3 by Activation of ERK/MKP7 to Attenuate AMPA Receptor Endocytosis in Alzheimer's Disease” - Wiley Online Library
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Intracellular Spermine Is a Key Player in GSG1L’s Regulation of Calcium-Permeable AMPAR Channel Conductance and Recovery from Desensitization - Journal of Neuroscience
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Essential oils from Artemisia judaica Ruta graveolens and Salvia palaestina with antiradical, cytotoxic and AMPA receptor-modulatory activities - Nature
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Linking Nanoscale Dynamics of AMPA Receptor Organization to Plasticity of Excitatory Synapses and Learning - Journal of Neuroscience
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PICK1 interacts with PACSIN to regulate AMPA receptor internalization and cerebellar long-term depression - PNAS
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Prolonged visual experience accelerates developmental synaptic downscaling via epigenetic regulation and Rab5c mediated AMPA receptor trafficking - Nature
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AMPA receptor structure and auxiliary subunits - Wiley
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Celebrating the Birthday of AMPA Receptor Nanodomains: Illuminating the Nanoscale Organization of Excitatory Synapses with 10 Nanocandles - Journal of Neuroscience
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Proton-triggered rearrangement of the AMPA receptor N-terminal domains impacts receptor kinetics and synaptic localization - Nature
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Hippocampal AMPA receptor assemblies and mechanism of allosteric inhibition - Nature
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AMPA-receptor specific biogenesis complexes control synaptic transmission and intellectual ability - Nature
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Regulation of AMPA receptor trafficking by secreted protein factors - Frontiers
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Structure of transmembrane AMPA receptor regulatory protein subunit γ2 - Nature
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High-resolution imaging and manipulation of endogenous AMPA receptor surface mobility during synaptic plasticity and learning - Science | AAAS
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Caspase-2 promotes AMPA receptor internalization and cognitive flexibility via mTORC2-AKT-GSK3β signaling - Nature
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Diminished Neuronal ESCRT-0 Function Exacerbates AMPA Receptor Derangement and Accelerates Prion-Induced Neurodegeneration - Journal of Neuroscience
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Modulatory mechanisms of TARP γ8-selective AMPA receptor therapeutics - Nature
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AMPA Receptor Trafficking for Postsynaptic Potentiation - Frontiers
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Celebrating the Birthday of AMPA Receptor Nanodomains: Illuminating the Nanoscale Organization of Excitatory Synapses with 10 Nanocandles - Journal of Neuroscience
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Recent Findings on AMPA Receptor Recycling - Frontiers
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Mechanisms of AMPA Receptor Endosomal Sorting - Frontiers
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binding site critical in regulating ion transport - Nature
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The Regulation of AMPA Receptor Endocytosis by Dynamic Protein-Protein Interactions - Frontiers
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Prolonged contextual fear memory in AMPA receptor palmitoylation-deficient mice - Nature
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Recurrent Anti-AMPA Receptor Limbic Encephalitis: A Case Report and Literature Review - Frontiers
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AMPA receptor GluA2 subunit defects are a cause of neurodevelopmental disorders - Nature
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-Phldb2 is crucial for LTP regulating synaptic NMDA and AMPA receptor density and PSD95 turnover - Nature
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Contribution of AMPA Receptor-Mediated LTD in LA/BLA-CeA Pathway to Comorbid Aversive and Depressive Symptoms in Neuropathic Pain - Journal of Neuroscience
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Ketamine induces opposite changes in AMPA receptor calcium permeability in the ventral tegmental area and nucleus accumbens | Translational Psychiatry - Nature
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AMPA Receptor Trafficking in Natural and Pathological Aging - Frontiers
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Assembly and Stoichiometry of the AMPA Receptor and Transmembrane AMPA Receptor Regulatory Protein Complex - Journal of Neuroscience
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Calcineurin and CK2 Reciprocally Regulate Synaptic AMPA Receptor Phenotypes via α2δ-1 in Spinal Excitatory Neurons - Journal of Neuroscience
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LRRTM2 controls presynapse nano-organization and AMPA receptor sub-positioning through Neurexin-binding interface - Nature
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How protons shape AMPA receptor structure, function and diffusion at the synapse - Nature
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Mechanisms underlying TARP modulation of the GluA1/2-γ8 AMPA receptor - Nature
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Characterization of patients with major psychiatric disorders with AMPA receptor positron emission tomography - Nature
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C9ORF72 repeat expansion causes vulnerability of motor neurons to Ca - Nature
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AMPA receptor exchange underlies transient memory destabilization on retrieval - PNAS
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AMPA Receptor Plasticity in the Nucleus Accumbens Mediates Withdrawal-Related Negative-Affective States - Journal of Neuroscience
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Modulation of AMPA receptor surface diffusion restores hippocampal plasticity and memory in Huntington’s disease models - Nature
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SHP2 regulates GluA2 tyrosine phosphorylation required for AMPA receptor endocytosis and mGluR-LTD - PNAS
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Akt and calcium-permeable AMPA receptor are involved in the effect of pinoresinol on amyloid β-induced synaptic plasticity and memory deficits - ScienceDirect.com
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AMPA receptor anchoring at CA1 synapses is determined by N-terminal domain and TARP γ8 interactions - Nature
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Alternative Splicing of the Flip/Flop Cassette and TARP Auxiliary Subunits Engage in a Privileged Relationship That Fine-Tunes AMPA Receptor Gating - Journal of Neuroscience
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Different AMPA receptor subtypes mediate the distinct kinetic components of a biphasic EPSC in hippocampal interneurons - Frontiers
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KIF13A drives AMPA receptor synaptic delivery for long-term potentiation via endosomal remodeling - Rockefeller University Press
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Posterior cortical and white matter changes on MRI in anti–AMPA receptor antibody encephalitis - Neurology® Journals
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Molecular Dissection of the Interaction between the AMPA Receptor and Cornichon Homolog-3 - Journal of Neuroscience
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A unique intracellular tyrosine in neuroligin-1 regulates AMPA receptor recruitment during synapse differentiation and potentiation - Nature
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S-nitrosylation of AMPA receptor GluA1 regulates phosphorylation, single-channel conductance, and endocytosis - PNAS
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Encephalitis and AMPA receptor antibodies - Neurology® Journals
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Ubiquitin ligase RNF167 regulates AMPA receptor-mediated synaptic transmission - PNAS
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AMPA receptors and stargazin-like transmembrane AMPA receptor-regulatory proteins mediate hippocampal kainate neurotoxicity - PNAS
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PKA drives an increase in AMPA receptor unitary conductance during LTP in the hippocampus - Nature
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Role of AMPA receptor desensitization in short term depression – lessons from retinogeniculate synapses - Wiley
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Bidirectional Dysregulation of AMPA Receptor-Mediated Synaptic Transmission and Plasticity in Brain Disorders - Frontiers
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AMPA receptor downscaling at the onset of Alzheimer’s disease pathology in double knockin mice - PNAS
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Hormonal regulation of AMPA receptor trafficking and memory formation - Frontiers
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GSG1L-containing AMPA receptor complexes are defined by their spatiotemporal expression, native interactome and allosteric sites - Nature
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Unified quantitative model of AMPA receptor trafficking at synapses - PNAS
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Dysfunction of AMPA receptor GluA3 is associated with aggressive behavior in human - Nature
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AMPA Receptor Function in Hypothalamic Synapses - Frontiers
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The essential role of AMPA receptor GluR2 subunit RNA editing in the normal and diseased brain - Frontiers
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Synaptotagmin-3 drives AMPA receptor endocytosis, depression of synapse strength, and forgetting - Science | AAAS
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Actin-dependent mechanisms in AMPA receptor trafficking - Frontiers
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SNP rs10420324 in the AMPA receptor auxiliary subunit TARP γ-8 regulates the susceptibility to antisocial personality disorder | Scientific Reports - Nature
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β3 integrin interacts directly with GluA2 AMPA receptor subunit and regulates AMPA receptor expression in hippocampal neurons - PNAS
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The neuronal K-Cl cotransporter KCC2 influences postsynaptic AMPA receptor content and lateral diffusion in dendritic spines - PNAS
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Role of GluA3 AMPA Receptor Subunits in the Presynaptic and Postsynaptic Maturation of Synaptic Transmission and Plasticity of Endbulb−Bushy Cell Synapses in the Cochlear Nucleus - Journal of Neuroscience
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The Prefrontal Dectin-1/AMPA Receptor Signaling Pathway Mediates The Robust and Prolonged Antidepressant Effect of Proteo-β-Glucan from Maitake - Nature
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AMPA receptor trafficking and its role in heterosynaptic plasticity - Nature
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Heterogeneity of AMPA receptor trafficking and molecular interactions revealed by superresolution analysis of live cell imaging - PNAS
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Regulation of Metabotropic Glutamate Receptor Internalization and Synaptic AMPA Receptor Endocytosis by the Postsynaptic Protein Norbin - Journal of Neuroscience
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Functional comparison of the effects of TARPs and cornichons on AMPA receptor trafficking and gating - PNAS
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Contribution of Postsynaptic Molecules to AMPA Receptor Nanodomain Organization - Journal of Neuroscience
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AMPA receptor-mTORC1 signaling activation is required for neuroplastic effects of LY341495 in rat hippocampal neurons - Nature
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Postsynaptic synaptotagmins mediate AMPA receptor exocytosis during LTP - Nature
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MAP1B Light Chain Modulates Synaptic Transmission via AMPA Receptor Intracellular Trapping - Journal of Neuroscience
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AMPA receptor pHluorin-GluA2 reports NMDA receptor-induced intracellular acidification in hippocampal neurons - PNAS
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Biodistribution and radiation dosimetry of the positron emission tomography probe for AMPA receptor, [ - Nature
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p97 regulates GluA1 homomeric AMPA receptor formation and plasma membrane expression - Nature
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New structures show how auxiliary subunits modulate hippocampal AMPA receptor neurotransmission - Medical Xpress
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Reactive Oxygen Species Modulate Activity-Dependent AMPA Receptor Transport in C. elegans - Journal of Neuroscience
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Elucidation of AMPA receptor–stargazin complexes by cryo–electron microscopy - Science | AAAS
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Not All Desensitizations Are Created Equal: Physiological Evidence That AMPA Receptor Desensitization Differs for Kainate and Glutamate - Journal of Neuroscience
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FUS regulates AMPA receptor function and FTLD/ALS-associated behaviour via GluA1 mRNA stabilization - Nature
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The Shaping of AMPA Receptor Surface Distribution by Neuronal Activity - Frontiers
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Role of the Ion Channel Extracellular Collar in AMPA Receptor Gating - Nature
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The diversity of AMPA receptor inhibition mechanisms among amidine-containing compounds - Frontiers
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Transcranial magnetic stimulation as a translational biomarker for AMPA receptor modulation - Nature
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A combination of NMDA and AMPA receptor antagonists retards granule cell dispersion and epileptogenesis in a model of acquired epilepsy - Nature
Why This Topic Is Trending
This topic has recently gained attention due to increased public interest. Search activity and Wikipedia pageviews suggest growing global engagement.
Search Interest & Related Topics
Search interest data over the past 12 months indicates that this topic periodically attracts global attention. Sudden spikes often correlate with major news events, public statements, or geopolitical developments.