Why is "ANO1" trending?
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- Date: 2026-03-17 14:04:31
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Wikipedia Overview
Anoctamin-1 (ANO1), also known as Transmembrane member 16A (TMEM16A), is a protein that, in humans, is encoded by the ANO1 gene. Anoctamin-1 is a voltage-gated calcium-activated anion channel, which acts as a chloride channel and a bicarbonate channel. additionally Anoctamin-1 is apical iodide channel.
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Search Interest Perspective
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ANO1 channels are expressed in mouse urethral smooth muscle but do not contribute to agonist or neurally evoked contractions - Nature
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Contribution of chloride channels to the action potential and contraction in human myometrium during labour - British Pharmacological Society | Journals
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ANO1: central role and clinical significance in non-neoplastic and neoplastic diseases - Frontiers
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A functional and robust cellular model for high-throughput screening of piezo1 modulators - Nature
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The emerging role of anoctamin-1 in cardiac and cerebrovascular diseases - Frontiers
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Multiple cAMP/PKA complexes at the STIM1 ER/PM junction specified by E-Syt1 and E-Syt2 reciprocally gates ANO1 (TMEM16A) via Ca - Nature
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Mechanism of action and therapeutic value of anoctamin-1 in gastrointestinal cancers - Frontiers
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High Ano1 expression as key driver of resistance to radiation and cisplatin in HPV-negative head and neck squamous cell carcinoma - Nature
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ANO1: More Than Just Calcium-Activated Chloride Channel in Cancer - Frontiers
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Promoter hypermethylation as a novel regulator of ANO1 expression and function in prostate cancer bone metastasis - Nature
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Low dose cadmium exposure regulates miR-381–ANO1 interaction in airway epithelial cells | Scientific Reports - Nature
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TRPV3-ANO1 interaction positively regulates wound healing in keratinocytes - Nature
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Prostaglandin E2 depolarises sensory axons in vitro in an ANO1 and Nav1.8 dependent manner - Nature
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Inhibition of ANO1/TMEM16A induces apoptosis in human prostate carcinoma cells by activating TNF-α signaling - Nature
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Detection of ANO1 mRNA in PBMCs is a promising method for GISTs diagnosis - Nature
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MicroRNA-9 downregulates the ANO1 chloride channel and contributes to cystic fibrosis lung pathology - Nature
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channel TMEM16A/ANO1 identified in zebrafish skeletal muscle is crucial for action potential acceleration - Nature
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Inhibition of mucus secretion by niclosamide and benzbromarone in airways and intestine - Nature
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DNA methylation regulates TMEM16A/ANO1 expression through multiple CpG islands in head and neck squamous cell carcinoma - Nature
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Suppression of 14-3-3γ-mediated surface expression of ANO1 inhibits cancer progression of glioblastoma cells - Nature
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ANO1 inhibits cardiac fibrosis after myocardial infraction via TGF-β/smad3 pathway - Nature
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Voltage- and calcium-dependent gating of TMEM16A/Ano1 chloride channels are physically coupled by the first intracellular loop - PNAS
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Anoctamin-1 is a core component of a mechanosensory anion channel complex in C. elegans - Nature
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ANO1: an additional key player in cyst growth - ScienceDirect.com
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ANO1 amplification and expression in HNSCC with a high propensity for future distant metastasis and its functions in HNSCC cell lines - Nature
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Dynamic modulation of ANO1/TMEM16A HCO3− permeability by Ca2+/calmodulin - PNAS
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ANO1-Mediated Inhibition of Cancer Ferroptosis Confers Immunotherapeutic Resistance through Recruiting Cancer-Associated Fibroblasts - Wiley
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Distinct modulation of calcium-activated chloride channel TMEM16A by drug-binding sites - PNAS
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COPD: The effect of low-dose cadmium, a highly toxic metal, on airway epithelial cells | UAB News - The University of Alabama at Birmingham
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Tamsulosin ameliorates bone loss by inhibiting the release of Cl− through wedging into an allosteric site of TMEM16A - PNAS
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Pain-enhancing mechanism through interaction between TRPV1 and anoctamin 1 in sensory neurons - PNAS
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Mapping of long-range INS promoter interactions reveals a role for calcium-activated chloride channel ANO1 in insulin secretion - PNAS
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Mechanical stimulation controls osteoclast function through the regulation of Ca - Nature
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TMEM16A/ANO1 is differentially expressed in HPV-negative versus HPV-positive head and neck squamous cell carcinoma through promoter methylation - Nature
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Clinical significance of Anoctamin-1 gene at 11q13 in the development and progression of head and neck squamous cell carcinomas - Nature
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Inhibition mechanism of the chloride channel TMEM16A by the pore blocker 1PBC - Nature
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Ani9, A Novel Potent Small-Molecule ANO1 Inhibitor with Negligible Effect on ANO2 - PLOS
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4-isopropylcyclohexanol has potential analgesic effects through the inhibition of anoctamin 1, TRPV1 and TRPA1 channel activities - Nature
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Niclosamide potentiates TMEM16A and induces vasoconstriction - Rockefeller University Press
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Cyst growth in ADPKD is prevented by pharmacological and genetic inhibition of TMEM16A in vivo - Nature
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Anoctamins (TMEM16 proteins) - Neurology® Journals
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The Calcium-Activated Chloride Channel TMEM16A is Inhibitied by Liquiritigenin - Frontiers
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The Prognostic Value and Mechanisms of TMEM16A in Human Cancer - Frontiers
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Cells and ionic conductances contributing to spontaneous activity in bladder and urethral smooth muscle - Wiley
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Calcium-activated chloride channel TMEM16A modulates mucin secretion and airway smooth muscle contraction - PNAS
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Physiological roles and diseases of tmem16/anoctamin proteins: are they all chloride channels? - Nature
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secretion induced by carbachol and cholera toxin - Nature
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TMEM16A/F support exocytosis but do not inhibit Notch-mediated goblet cell metaplasia of BCi-NS1.1 human airway epithelium - Frontiers
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Voltage-Dependent Protonation of the Calcium Pocket Enable Activation of the Calcium-Activated Chloride Channel Anoctamin-1 (TMEM16A) - Nature
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Temporal Expression Patterns of Clock Genes and Aquaporin 5/Anoctamin 1 in Rat Submandibular Gland Cells - Frontiers
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Tonic inhibition of murine proximal colon is due to nitrergic suppression of Ca - Nature
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Role of Quercetin in Modulating Chloride Transport in the Intestine - Frontiers
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ANO9/TMEM16J promotes tumourigenesis via EGFR and is a novel therapeutic target for pancreatic cancer - Nature
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Gene expression may help predict treatment response in thyroid cancer - Karolinska Institutet
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Transient Magnetothermal Neuronal Silencing Using the Chloride Channel Anoctamin 1 (TMEM16A) - Frontiers
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Modulation of Chloride Channel Functions by the Plant Lignan Compounds Kobusin and Eudesmin - Frontiers
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The Two-Step Amplification Of Pain - Asian Scientist Magazine
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TMEM16A controls EGF-induced calcium signaling implicated in pancreatic cancer prognosis - PNAS
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ANO4 (Anoctamin 4) Is a Novel Marker of Zona Glomerulosa That Regulates Stimulated Aldosterone Secretion - American Heart Association Journals
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Case Report Examines Function of Chloride Channel TMEM16A in CF - Cystic Fibrosis News Today
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Cryo-EM structures of the TMEM16A calcium-activated chloride channel - Nature
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Niclosamide does not modulate airway epithelial function through blocking of the calcium activated chloride channel, TMEM16A - Frontiers
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DOG1: a novel marker of salivary acinar and intercalated duct differentiation - Nature
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-activated chloride channel TMEM16A - Nature
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Specific PIP2 binding promotes calcium activation of TMEM16A chloride channels | Communications Biology - Nature
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An ancestral TMEM16 homolog from Dictyostelium discoideum forms a scramblase - PLOS
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One Step Closer to Restoring Respiratory Function in Cystic Fibrosis? - Salle de presse de l'Inserm
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