Why is "ASIC1" trending?

Search Interest Perspective

• The secreted protein PCYOX1L controls the surface expression of acid-sensing ion channel 1a - Science | AAAS
• Molecular mechanisms and hotspots of pH sensing in ASIC1a revealed by computational and functional analysis - Nature
• Selective blockade of acid-sensing ion channel 1a can provide substantial hippocampal neuroprotection - Frontiers
• Molecular determinants of ASIC1 modulation by divalent cations - Nature
• A brain-specific SGK1 splice isoform regulates expression of ASIC1 in neurons - PNAS
• McGill University and Neurasic Therapeutics discover new ASIC1 blockers for pain - BioWorld News
• Upregulation of Spinal ASIC1 and NKCC1 Expression Contributes to Chronic Visceral Pain in Rats - Frontiers
• ASIC1 and ASIC3 contribute to acidity-induced EMT of pancreatic cancer through activating Ca - Nature
• The Role of ASIC1a in Inflammatory Immune Diseases: A Potential Therapeutic Target - Frontiers
• Acid-sensing ion channel 1a modulation of apoptosis in acidosis-related diseases: implications for therapeutic intervention - Nature
• Acid-Sensing Ion Channel 1 Contributes to Weak Acid-Induced Migration of Human Malignant Glioma Cells - Frontiers
• Conformational sampling on acid-sensing ion channel 1 (ASIC1): implication for a symmetric conformation - Nature
• ERK-mediated NF-κB activation through ASIC1 in response to acidosis - Nature
• Structure of the Acid-sensing ion channel 1 in complex with the gating modifier Psalmotoxin 1 - Nature
• Shear force modulates the activity of acid-sensing ion channels at low pH or in the presence of non-proton ligands - Nature
• Outlines of the pore in open and closed conformations describe the gating mechanism of ASIC1 - Nature
• Histone Modifications in a Mouse Model of Early Adversities and Panic Disorder: Role for Asic1 and Neurodevelopmental Genes - Nature
• Acidosis induces RIPK1-dependent death of glioblastoma stem cells via acid-sensing ion channel 1a - Nature
• Physiologically relevant acid-sensing ion channel (ASIC) 2a/3 heteromers have a 1:2 stoichiometry - Nature
• ASIC mind - Nature
• Astrocytic Acid-Sensing Ion Channel 1a Contributes to the Development of Chronic Epileptogenesis - Nature
• Glutamate acts on acid-sensing ion channels to worsen ischaemic brain injury - Nature
• Mutations in the palm domain disrupt modulation of acid-sensing ion channel 1a currents by neuropeptides - Nature
• Citric Acid in Drug Formulations Causes Pain by Potentiating Acid-Sensing Ion Channel 1 - Journal of Neuroscience
• Acid-Sensing Ion Channels: Expression and Function in Resident and Infiltrating Immune Cells in the Central Nervous System - Frontiers
• Acid-sensing ion channels are expressed in the ventrolateral medulla and contribute to central chemoreception - Nature
• Acid-Sensing Ion Channel 1 Is Localized in Brain Regions with High Synaptic Density and Contributes to Fear Conditioning - Journal of Neuroscience
• Mambalgin-3 potentiates human acid-sensing ion channel 1b under mild to moderate acidosis: Implications as an analgesic lead - PNAS
• Glioblastoma cancer stem cell lines express functional acid sensing ion channels ASIC1a and ASIC3 - Nature
• Potentially repurposable drugs for schizophrenia identified from its interactome - Nature
• Oxidant regulated inter-subunit disulfide bond formation between ASIC1a subunits - PNAS
• Acid-sensitive ionic channels in midbrain dopamine neurons are sensitive to ammonium, which may contribute to hyperammonemia damage - PNAS
• The role of macrophage ion channels in the progression of atherosclerosis - Frontiers
• Functional and pharmacological characterization of two different ASIC1a/2a heteromers reveals their sensitivity to the spider toxin PcTx1 | Scientific Reports - Nature
• β-Estradiol Protects Against Acidosis-Mediated and Ischemic Neuronal Injury by Promoting ASIC1a (Acid-Sensing Ion Channel 1a) Protein Degradation - American Heart Association Journals
• Targeting ASIC1a Promotes Neural Progenitor Cell Migration and Neurogenesis in Ischemic Stroke - Science Partner Journals
• Signaling Pathways in Proton and Non-proton ASIC1a Activation - Frontiers
• Human ASIC3 channel dynamically adapts its activity to sense the extracellular pH in both acidic and alkaline directions - PNAS
• New Intel IPUs and Mount Evans ASIC is its First DPU Sheds x86 - ServeTheHome
• ASIC-dependent LTP at multiple glutamatergic synapses in amygdala network is required for fear memory - Nature
• Intel Architecture Day 2021 IPU Mount Evans ASIC Block Diagram - ServeTheHome
• New Intel Mount Evans IPU ASIC DPU at Intel Vision 2022 - ServeTheHome