Why is "ATG16L1" trending?

Search Interest Perspective

• ATG16L1 controls mammalian vacuolar proton ATPase - Rockefeller University Press
• Molecular bases of the interactions of ATG16L1 with FIP200 and ATG8 family proteins - Nature
• Atg16L1 T300A variant decreases selective autophagy resulting in altered cytokine signaling and decreased antibacterial defense - PNAS
• ATG16L strikes again! New findings link lysosome stress and physiology - Rockefeller University Press
• ATG16L1 rs2241880/T300A increases susceptibility to perianal Crohn's disease: An updated meta‐analysis on inflammatory bowel disease risk and clinical outcomes - Simovic - 2024 - United European Gastroenterology Journal - Wiley Online Library
• LC3-associated endocytosis and the functions of Rubicon and ATG16L1 - Science | AAAS
• Tumor-intrinsic expression of the autophagy gene Atg16l1 suppresses anti-tumor immunity in colorectal cancer - Nature
• ATG16L1 restrains macrophage NLRP3 activation and alveolar epithelial cell injury during septic lung injury - Wiley Online Library
• The Chlamydia effector CT622/TaiP targets a nonautophagy related function of ATG16L1 - PNAS
• Autophagy-enhancing ATG16L1 polymorphism is associated with improved clinical outcome and T-cell immunity in chronic HIV-1 infection - Nature
• ATG16L1 orchestrates interleukin-22 signaling in the intestinal epithelium via cGAS–STING - Rockefeller University Press
• Distinct functions of ATG16L1 isoforms in membrane binding and LC3B lipidation in autophagy-related processes - Nature
• Crystal structure of the Rab33B/Atg16L1 effector complex - Nature
• Gigaxonin E3 ligase governs ATG16L1 turnover to control autophagosome production - Nature
• ATG16L1 induces the formation of phagophore-like membrane cups - Nature
• Physical and functional interaction between A20 and ATG16L1-WD40 domain in the control of intestinal homeostasis - Nature
• TMEM166/EVA1A interacts with ATG16L1 and induces autophagosome formation and cell death - Nature
• Regulation of cytokine signaling through direct interaction between cytokine receptors and the ATG16L1 WD40 domain - Nature
• A key role for autophagy and the autophagy gene Atg16l1 in mouse and human intestinal Paneth cells - Nature
• NOD1 deficiency promotes inflammation via autophagic degradation of ASK1 - Nature
• A Crohn’s disease variant in Atg16l1 enhances its degradation by caspase 3 - Nature
• TMEM74 promotes tumor cell survival by inducing autophagy via interactions with ATG16L1 and ATG9A - Nature
• The T300A Crohn’s disease risk polymorphism impairs function of the WD40 domain of ATG16L1 - Nature
• The ATG16L1 risk allele associated with Crohn’s disease results in a Rac1-dependent defect in dendritic cell migration that is corrected by thiopurines - Nature
• Loss of the autophagy protein Atg16L1 enhances endotoxin-induced IL-1β production - Nature
• miR-142-3p regulates autophagy by targeting ATG16L1 in thymic-derived regulatory T cell (tTreg) - Nature
• An ATG16L1-dependent pathway promotes plasma membrane repair and limits Listeria monocytogenes cell-to-cell spread - Nature
• Promotion of TLR7-MyD88-dependent inflammation and autoimmunity in mice through stem-loop changes in Lnc-Atg16l1 - Nature
• Control of infection by LC3-associated phagocytosis, CASM, and detection of raised vacuolar pH by the V-ATPase-ATG16L1 axis - Science | AAAS
• Nod1 and Nod2 direct autophagy by recruiting ATG16L1 to the plasma membrane at the site of bacterial entry - Nature
• STING induces LC3B lipidation onto single-membrane vesicles via the V-ATPase and ATG16L1-WD40 domain - Rockefeller University Press
• Autophagy regulates Notch degradation and modulates stem cell development and neurogenesis - Nature
• Association analysis of genetic variants in IL23R ATG16L1 and 5p13.1 loci with Crohn’s disease in Japanese patients - Nature
• V-ATPase is a universal regulator of LC3-associated phagocytosis and non-canonical autophagy - Rockefeller University Press
• ATG5 cancer mutations and alternative mRNA splicing reveal a conjugation switch that regulates ATG12–ATG5-ATG16L1 complex assembly and autophagy - Nature
• Research Suggests New Way to Treat Inflammatory Gut Disease & Prevent Bone Marrow Transplant Rejection - NYU Langone Health
• Interaction between FIP200 and ATG16L1 distinguishes ULK1 complex–dependent and –independent autophagy - Nature
• Full article: An alteration in ATG16L1 stability in Crohn disease - Taylor & Francis Online
• Genetic variants of the autophagy pathway as prognostic indicators for prostate cancer - Nature
• STING-induced noncanonical autophagy regulates endolysosomal homeostasis - PNAS
• Full article: ATG16L1 meets ATG9 in recycling endosomes - Taylor & Francis Online
• The Crohn’s disease-associated polymorphism in ATG16L1 (rs2241880) reduces SHIP gene expression and activity in human subjects - Nature
• Association of ATG16L1 and IRGM genes polymorphisms with inflammatory bowel disease: a meta-analysis approach - Nature
• LINC00963/miR-4458 regulates the effect of oxaliplatin in gastric cancer by mediating autophagic flux through targeting of ATG16L1 - Nature
• miR-96 attenuates status epilepticus-induced brain injury by directly targeting Atg7 and Atg16L1 - Nature
• Association between genetic polymorphisms in the autophagy-related 5 gene promoter and the risk of sepsis - Nature
• A genome-wide association scan of nonsynonymous SNPs identifies a susceptibility variant for Crohn disease in ATG16L1 - Nature
• Lysosome-associated CASM: from upstream triggers to downstream effector mechanisms - Frontiers
• Streptococcus pneumoniae triggers hierarchical autophagy through reprogramming of LAPosome-like vesicles via NDP52-delocalization - Nature
• How autophagy, a potential therapeutic target, regulates intestinal inflammation - Frontiers
• ATG16L2 inhibits NLRP3 inflammasome activation through promoting ATG5-12-16L1 complex assembly and autophagy - Wiley Online Library
• Noncanonical function of an autophagy protein prevents spontaneous Alzheimer’s disease - Science | AAAS
• An unconventional autophagic pathway that inhibits ATP secretion during apoptotic cell death - Nature
• Formation of the autophagy elongation complex in Huh7 cells. - PLOS
• A PI3K-WIPI2 positive feedback loop allosterically activates LC3 lipidation in autophagy - Rockefeller University Press
• Nuclear proteasomes buffer cytoplasmic proteins during autophagy compromise - Nature
• Perturbation of ATG16L1 function impairs the biogenesis of Salmonella and Coxiella replication vacuoles - Wiley Online Library
• Pattern Recognition Receptors and Autophagy - Frontiers
• HS1BP3 negatively regulates autophagy by modulation of phosphatidic acid levels - Nature
• LC3-positive structures are prominent in autophagy-deficient cells - Nature
• Phosphorylation regulates the binding of autophagy receptors to FIP200 Claw domain for selective autophagy initiation - Nature
• Atg8ylation as a host-protective mechanism against Mycobacterium tuberculosis - Frontiers
• SPATA33 is an autophagy mediator for cargo selectivity in germline mitophagy - Nature
• Full article: RABEP1/Rabaptin5: a link between autophagy and early endosome homeostasis - Taylor & Francis Online
• Canonical and Non-Canonical Functions of the Autophagy Machinery in MHC Restricted Antigen Presentation - Frontiers
• Attenuation of autophagy impacts on muscle fibre development, starvation induced stress and fibre regeneration following acute injury - Nature
• Small-molecule enhancers of autophagy modulate cellular disease phenotypes suggested by human genetics - PNAS
• Autophagy of mucin granules contributes to resolution of airway mucous metaplasia - Nature
• Mechanisms and roles of membrane-anchored ATG8s - Frontiers
• High-throughput screening for natural compound-based autophagy modulators reveals novel chemotherapeutic mode of action for arzanol - Nature
• The germline-enriched Ppp1r36 promotes autophagy - Nature
• Autophagosome formation: not necessarily an inside job - Nature
• Autophagosome formation in response to intracellular bacterial invasion - Shibutani - 2014 - Cellular Microbiology - Wiley Online Library
• NCB paper from Alf Håkon Lystad: Novel insight into autophagy related processes - UiO Det medisinske fakultet
• Unveiling a novel mechanism for detection and response to intracellular membrane damage - UiO Det medisinske fakultet