Why is "ATOX1" trending?
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Trend Analysis
- Ranking position: #
- Date: 2026-04-11 19:36:39
This topic has appeared in the trending rankings 1 time(s) in the past year. While it does not trend frequently, its appearance suggests a renewed or concentrated surge of public interest.
Based on Wikipedia pageviews and search interest, this topic gained significant attention on the selected date.
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Wikipedia Overview
ATOX1 is a copper metallochaperone protein that is encoded by the ATOX1 gene in humans. In mammals, ATOX1 plays a key role in copper homeostasis as it delivers copper from the cytosol to transporters ATP7A and ATP7B. Homologous proteins are found in a wide variety of eukaryotes, including Saccharomyces cerevisiae as ATX1, and all contain a conserved metal binding domain.
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Trending Topic Today
Search Interest Perspective
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CRISPR-Cas9 screening identifies ATOX1-driven cisplatin resistance mechanisms in liver cancer and evaluates targeted inhibitor efficacy | Communications Biology - Nature
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ATOX1 promotes hepatocellular carcinoma carcinogenesis via activation of the c-Myb/PI3K/AKT signaling pathway - EurekAlert!
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The effect of cuproptosis-related gene Atox1 on cardiac hypertrophy in heart failure was investigated based on bioinformatics analysis - Nature
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APEX2-based Proximity Labeling of Atox1 Identifies CRIP2 as a Nuclear Copper-binding Protein that Regulates Autophagy Activation - Wiley Online Library
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Complanatoside A disrupts copper homeostasis and induces cuproptosis via directly targeting ATOX1 in prostate cancer - ScienceDirect.com
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Dependence of Atox1 and p53 levels in HCT116 and A549 cell lines with different TP53 status. - PLOS
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APEX2-based Proximity Labeling of Atox1 Identifies CRIP2 as a Nuclear Copper-binding Protein that Regulates Autophagy Activation - Wiley Online Library
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Disrupting Cu trafficking as a potential therapy for cancer - Frontiers
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Nuclear translocation of Atox1 potentiates activin A-induced cell migration and colony formation in colon cancer - PLOS
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Cancer cells spread using a copper-binding protein - Chalmers tekniska högskola
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Copper Transport Protein Antioxidant-1 Promotes Inflammatory Neovascularization via Chaperone and Transcription Factor Function - Nature
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Copper-instigated modulatory cell mortality mechanisms and progress in oncological treatment investigations - Frontiers
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Copper is essential for cyclin B1-mediated CDK1 activation - Nature
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Endothelial Antioxidant-1: a Key Mediator of Copper-dependent Wound Healing in vivo - Nature
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Human glutaredoxin-1 can transfer copper to isolated metal binding domains of the P - Nature
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Tetrathiomolybdate induces dimerization of the metal-binding domain of ATPase and inhibits platination of the protein - Nature
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Structure and dimerization properties of the plant-specific copper chaperone CCH - Nature
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Neuronal differentiation is associated with a redox-regulated increase of copper flow to the secretory pathway - Nature
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Enthalpy-entropy compensation at play in human copper ion transfer - Nature
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Metallothioneins regulate ATP7A trafficking and control cell viability during copper deficiency and excess - Nature
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The Structure of Metal Binding Domain 1 of the Copper Transporter ATP7B Reveals Mechanism of a Singular Wilson Disease Mutation - Nature
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New study shows inhibiting copper chaperones reduces tumor cell proliferation - Phys.org
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Cuproptosis: Mechanisms, biological significance, and advances in disease treatment—A systematic review - Wiley Online Library
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Copper Transporter ATP7A (Copper-Transporting P-Type ATPase/Menkes ATPase) Limits Vascular Inflammation and Aortic Aneurysm Development: - American Heart Association Journals
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Evaluating gene expression and biomarkers for mastitis resistance in Barki sheep - Nature
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Copper a clue in the fight against cancer - Chalmers tekniska högskola
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Putative Concussion Biomarkers Identified in Adolescent Male Athletes Using Targeted Plasma Proteomics - Frontiers
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