Why is "Acid-sensing ion channel" trending?

Search Interest Perspective

• The secreted protein PCYOX1L controls the surface expression of acid-sensing ion channel 1a - Science | AAAS
• The relationship between acid-sensing ion channel, ASIC2 , and oncogenic β-catenin signaling in ovarian cancer - Nature
• Selective blockade of acid-sensing ion channel 1a can provide substantial hippocampal neuroprotection - Frontiers
• Meet WRPRFa: the precision peptide changing how we study pain - Drug Target Review
• -dependent conformational changes in the transmembrane domain - Nature
• Mechanism of acid-sensing ion channel modulation by Hi1a - Rockefeller University Press
• Mambalgin-3 potentiates human acid-sensing ion channel 1b under mild to moderate acidosis: Implications as an analgesic lead - PNAS
• β-Estradiol Protects Against Acidosis-Mediated and Ischemic Neuronal Injury by Promoting ASIC1a (Acid-Sensing Ion Channel 1a) Protein Degradation - American Heart Association Journals
• Acid-sensing ion channel blocker diminazene facilitates proton-induced excitation of afferent nerves in a similar manner that Na+/H+ exchanger blockers do - Frontiers
• Acid-sensing ion channel 3 matches the acid-gated current in cardiac ischemia-sensing neurons - PNAS
• Acid-sensing ion channel 1a promotes alcohol-associated liver disease in mice via regulating endoplasmic reticulum autophagy - Nature
• Acid-Sensing Ion Channel-1a in Articular Chondrocytes and Synovial Fibroblasts: A Novel Therapeutic Target for Rheumatoid Arthritis - Frontiers
• Acid-sensing ion channel 1a modulation of apoptosis in acidosis-related diseases: implications for therapeutic intervention - Nature
• Physiologically relevant acid-sensing ion channel (ASIC) 2a/3 heteromers have a 1:2 stoichiometry - Nature
• Acidosis induces RIPK1-dependent death of glioblastoma stem cells via acid-sensing ion channel 1a - Nature
• Mutations in the palm domain disrupt modulation of acid-sensing ion channel 1a currents by neuropeptides - Nature
• -binding site in rat acid-sensing ion channel 3 - Nature
• Acid-sensing ion channel 3 is a new potential therapeutic target for the control of glioblastoma cancer stem cells growth - Nature
• Acid-sensing ion channel 1a contributes to hippocampal LTP inducibility through multiple mechanisms - Nature
• Acid-sensing ion channel (ASIC) 4 predominantly localizes to an early endosome-related organelle upon heterologous expression - Nature
• Acid-Sensing Ion Channel 1a in the amygdala is involved in pain and anxiety-related behaviours associated with arthritis - Nature
• Commentary: Effects of acid-sensing ion channel-1A (ASIC1A) on cocaine-induced synaptic adaptations - Frontiers
• Acidic pH promotes intervertebral disc degeneration: Acid-sensing ion channel -3 as a potential therapeutic target - Nature
• Extracellular acidosis increases neuronal cell calcium by activating acid-sensing ion channel 1a - PNAS
• Acid-Sensing Ion Channel 2a (ASIC2a) Promotes Surface Trafficking of ASIC2b via Heteromeric Assembly - Nature
• Interleukin-6 enhances acid-induced apoptosis via upregulating acid-sensing ion channel 1a expression and function in rat articular chondrocytes - ScienceDirect.com
• Molecular mechanism and structural basis of small-molecule modulation of the gating of acid-sensing ion channel 1 - Nature
• Deactivation kinetics of acid-sensing ion channel 1a are strongly pH-sensitive - PNAS
• Structural plasticity and dynamic selectivity of acid-sensing ion channel–spider toxin complexes - Nature
• Glucose Deficiency Elevates Acid-Sensing Ion Channel 2a Expression and Increases Seizure Susceptibility in Temporal Lobe Epilepsy - Nature
• Potentiation of acid-sensing ion channel activity by peripheral group I metabotropic glutamate receptor signaling - ScienceDirect.com
• Astrocytic Acid-Sensing Ion Channel 1a Contributes to the Development of Chronic Epileptogenesis | Scientific Reports - Nature
• The role of acid sensing ion channels in the cardiovascular function - Frontiers
• Dynorphin Opioid Peptides Enhance Acid-Sensing Ion Channel 1a Activity and Acidosis-Induced Neuronal Death - Journal of Neuroscience
• Molecular Mechanism of Constitutive Endocytosis of Acid-Sensing Ion Channel 1a and Its Protective Function in Acidosis-Induced Neuronal Death - Journal of Neuroscience
• Acid-Sensing Ion Channel 1 Contributes to Weak Acid-Induced Migration of Human Malignant Glioma Cells - Frontiers
• Upregulation of acid sensing ion channel 1a (ASIC1a) by hydrogen peroxide through the JNK pathway - Nature
• Acid-Sensing Ion Channels: Expression and Function in Resident and Infiltrating Immune Cells in the Central Nervous System - Frontiers
• Structure of the Acid-sensing ion channel 1 in complex with the gating modifier Psalmotoxin 1 - Nature
• Molecular Mechanism of Constitutive Endocytosis of Acid-Sensing Ion Channel 1a and Its Protective Function in Acidosis-Induced Neuronal Death - Journal of Neuroscience
• Conformational sampling on acid-sensing ion channel 1 (ASIC1): implication for a symmetric conformation - Nature
• Novel mechanosensory role for acid sensing ion channel subtype 1a in evoking the exercise pressor reflex in rats with heart failure - Wiley
• Cholestane-3β,5α,6β-Triol Inhibits Acid-Sensing Ion Channels and Reduces Acidosis-Mediated Ischemic Brain Injury - American Heart Association Journals
• Acid-Sensing Ion Channels: - American Heart Association Journals
• Shear force modulates the activity of acid-sensing ion channels at low pH or in the presence of non-proton ligands - Nature
• Neurodegenerative Disease: What Potential Therapeutic Role of Acid-Sensing Ion Channels? - Frontiers
• Structure of acid-sensing ion channel 1 at 1.9 Å resolution and low pH - Nature
• Amiloride-Insensitive Currents of the Acid-Sensing Ion Channel-2a (ASIC2a)/ASIC2b Heteromeric Sour-Taste Receptor Channel - Journal of Neuroscience
• Acid-Sensing Ion Channels Activated by Evoked Released Protons Modulate Synaptic Transmission at the Mouse Calyx of Held Synapse - Journal of Neuroscience
• Multiscale molecular dynamics simulations predict arachidonic acid binding sites in human ASIC1a and ASIC3 transmembrane domains - Rockefeller University Press
• Glutamate acts on acid-sensing ion channels to worsen ischaemic brain injury - Nature
• Acid-Sensing Ion Channels Drive the Generation of Tactile Impulses in Merkel Cell–Neurite Complexes of the Glabrous Skin of Rodent Hindpaws - Journal of Neuroscience
• Ketone Bodies Inhibit the Opening of Acid-Sensing Ion Channels (ASICs) in Rat Hippocampal Excitatory Neurons in vitro - Frontiers
• Receptors in Dorsal Root Ganglia: Is a Labeled-Line Coding for Acid Nociception Possible? - Frontiers
• Coupling structure with function in acid-sensing ion channels: challenges in pursuit of proton sensors - Wiley
• Disruption of auto-inhibition underlies conformational signaling of ASIC1a to induce neuronal necroptosis - Nature
• Activation of acid-sensing ion channels by localized proton transient reveals their role in proton signaling - Nature
• Acid-sensing ion channel 1 contributes to pulmonary arterial smooth muscle cell depolarization following hypoxic pulmonary hypertension - Wiley
• Distribution of Acid Sensing Ion Channels in Axonal Growth Cones and Presynaptic Membrane of Cultured Hippocampal Neurons - Frontiers
• Acid-Sensing Ion Channels: - American Heart Association Journals
• Modulation of Ionotropic Glutamate Receptors and Acid-Sensing Ion Channels by Nitric Oxide - Frontiers
• Oncology Reports - Spandidos Publications
• A role for substance P and acid-sensing ion channel 1a in prolotherapy with dextrose-mediated analgesia in a mouse model of chronic muscle pain - Lippincott Home
• Editorial: ASICs: structure, function, and pharmacology, part II - Frontiers
• Acid-Sensing Ion Channel 1 Is Localized in Brain Regions with High Synaptic Density and Contributes to Fear Conditioning - Journal of Neuroscience
• Intracellular ASIC1a regulates mitochondrial permeability transition-dependent neuronal death - Nature
• Acid-sensing ion channel-1 contributes to axonal degeneration in autoimmune inflammation of the central nervous system - Nature
• C-Jun N-Terminal Kinase Post-Translational Regulation of Pain-Related Acid-Sensing Ion Channels 1b and 3 - Journal of Neuroscience
• Heteromeric Acid-Sensing Ion Channels (ASICs) Composed of ASIC2b and ASIC1a Display Novel Channel Properties and Contribute to Acidosis-Induced Neuronal Death - Journal of Neuroscience
• The Role of ASIC1a in Inflammatory Immune Diseases: A Potential Therapeutic Target - Frontiers
• Neuropeptides and degenerin/epithelial Na+ channels: a relationship from mammals to cnidarians - Wiley
• Signaling Pathways in Proton and Non-proton ASIC1a Activation - Frontiers
• Molecular determinants of ASIC1 modulation by divalent cations - Scientific Reports - Nature
• Ion Selectivity in the Selectivity Filters of Acid-Sensing Ion Channels - Nature
• Glioblastoma cancer stem cell lines express functional acid sensing ion channels ASIC1a and ASIC3 - Nature
• ASIC inhibits addiction - Nature
• Acid-sensing ion channels are expressed in the ventrolateral medulla and contribute to central chemoreception - Nature
• Dual actions of Psalmotoxin at ASIC1a and ASIC2a heteromeric channels (ASIC1a/2a) - Nature
• The Mechanosensitivity of Mouse Colon Afferent Fibers and Their Sensitization by Inflammatory Mediators Require Transient Receptor Potential Vanilloid 1 and Acid-Sensing Ion Channel 3 - Journal of Neuroscience
• Acid-Induced Pain and Its Modulation in Humans - Journal of Neuroscience
• ASIC1a affects hypothalamic signaling and regulates the daily rhythm of body temperature in mice - Nature
• Protons as Messengers of Intercellular Communication in the Nervous System - Frontiers
• Human ASIC3 channel dynamically adapts its activity to sense the extracellular pH in both acidic and alkaline directions - PNAS
• ASIC1a regulates insular long-term depression and is required for the extinction of conditioned taste aversion - Nature
• Functional and pharmacological characterization of two different ASIC1a/2a heteromers reveals their sensitivity to the spider toxin PcTx1 - Nature
• Evidence for the involvement of ASIC3 in sensory mechanotransduction in proprioceptors - Nature
• ASIC-dependent LTP at multiple glutamatergic synapses in amygdala network is required for fear memory - Nature
• Calcium-permeable ion channels involved in glutamate receptor-independent ischemic brain injury - Nature
• McGill University and Neurasic Therapeutics discover new ASIC1 blockers for pain - BioWorld MedTech
• Nonsteroid Anti-Inflammatory Drugs Inhibit Both the Activity and the Inflammation-Induced Expression of Acid-Sensing Ion Channels in Nociceptors - Journal of Neuroscience