Why is "Actin filament" trending?
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- Date: 2026-03-25 00:05:57
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Wikipedia Overview
Actin filaments are protein filaments in the cytoplasm of eukaryotic cells that form part of the cytoskeleton. They are primarily composed of polymers of actin, but are modified by and interact with numerous other proteins in the cell. Actin filaments are usually about 7 nm in diameter and made up of two strands of actin. Microfilament functions include cytokinesis, amoeboid movement, cell motility, changes in cell shape, endocytosis and exocytosis, cell contractility, and mechanical stability. In inducing cell motility, one end of the actin filament elongates while the other end contracts, presumably by myosin II molecular motors. Additionally, they function as part of actomyosin-driven contractile molecular motors, wherein the thin filaments serve as tensile platforms for myosin's ATP-dependent pulling action in muscle contraction and pseudopod advancement. Microfilaments have a tough, flexible framework which helps the cell in movement.
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Search Interest Perspective
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R5 and R7 positions on fluoroquinolone scaffolds drive F-actin filament disruption - Nature
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Dancing proteins keep cells moving: Redefining the function and role of key factors in actin filament disassembly - Phys.org
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Activation of Arp2/3 complex by a SPIN90 dimer in linear actin-filament nucleation - Nature
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Molecular mechanism of actin filament elongation by formins - Science | AAAS
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The actin filament pointed-end depolymerase Srv2/CAP depolymerizes barbed ends, displaces capping protein, and promotes formin processivity - PNAS
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SH3BGRL proteins are thioredoxin fold–containing actin filament pointed end capping proteins (TPECs) - Nature
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Study unravels the mysteries of actin filament polarity - pennmedicine.org
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Twinfilin is a nonprocessive depolymerase which synergizes with formin to dramatically accelerate actin filament uncapping by 300-fold - PNAS
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Structural basis of actin filament assembly and aging - Nature
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Cortactin stabilizes actin branches by bridging activated Arp2/3 to its nucleated actin filament - Nature
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Mechanism of synergistic actin filament pointed end depolymerization by cyclase-associated protein and cofilin - Nature
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Mechanism of actin filament severing and capping by gelsolin - Nature
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Mechanisms of actin filament severing and elongation by formins - Nature
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Forces generated by lamellipodial actin filament elongation regulate the WAVE complex during cell migration - Nature
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Biased localization of actin binding proteins by actin filament conformation - Nature
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4polar-STORM polarized super-resolution imaging of actin filament organization in cells - Nature
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A structural model of the profilin–formin pacemaker system for actin filament elongation - Nature
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An actin filament branching surveillance system regulates cell cycle progression, cytokinesis and primary ciliogenesis - Nature
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Brain proteomic analysis implicates actin filament processes and injury response in resilience to Alzheimer’s disease - Nature
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Cytokinesis requires localized β-actin filament production by an actin isoform specific nucleator - Nature
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Actin Filament Pointed Ends: Assays for Regulation of Assembly and Disassembly by Tropomodulin and Tropomyosin - Wiley Online Library
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Mapping the actin filament with myosin - PNAS
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Cryo-EM structures reveal how phosphate release from Arp3 weakens actin filament branches formed by Arp2/3 complex - Nature
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A role for cross-linking proteins in actin filament network organization and force generation - PNAS
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The structure of the actin filament uncapping complex mediated by twinfilin - Science | AAAS
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INF2-mediated actin filament reorganization confers intrinsic resilience to neuronal ischemic injury - Nature
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Celebrating 20 years of live single-actin-filament studies with five golden rules - PNAS
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Structural basis for cofilin binding and actin filament disassembly - Nature
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Direct real-time observation of actin filament branching mediated by Arp2/3 complex using total internal reflection fluorescence microscopy - PNAS
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High-resolution yeast actin structures indicate the molecular mechanism of actin filament stiffening by cations - Nature
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Unusual dynamics of the divergent malaria parasite PfAct1 actin filament - PNAS
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Illuminating cortactin structure and function at actin filament branches - Nature
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Synergy between Cyclase-associated protein and Cofilin accelerates actin filament depolymerization by two orders of magnitude - Nature
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Myosin Va molecular motors manoeuvre liposome cargo through suspended actin filament intersections in vitro - Nature
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Minimal requirements for actin filament disassembly revealed by structural analysis of malaria parasite actin-depolymerizing factor 1 - PNAS
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Self-organization of actin filament orientation in the dendritic-nucleation/array-treadmilling model - PNAS
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mDia1 senses both force and torque during F-actin filament polymerization - Nature
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Phosphatidylinositol-dependent actin filament binding by the SWI/SNF-like BAF chromatin remodeling complex - PNAS
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Insertional assembly of actin filament barbed ends in association with formins produces piconewton forces - PNAS
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IRSp53 promotes postsynaptic density formation and actin filament bundling - Rockefeller University Press
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Membrane-bound myosin IC drives the chiral rotation of the gliding actin filament around its longitudinal axis - Nature
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Characterization of Actin Filament Dynamics during Mitosis in Wheat Protoplasts under UV-B Radiation - Nature
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Polymerization force–regulated actin filament–Arp2/3 complex interaction dominates self-adaptive cell migrations - PNAS
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An actin-filament-binding interface on the Arp2/3 complex is critical for nucleation and branch stability - PNAS
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Single-Molecule Speckle Analysis of Actin Filament Turnover in Lamellipodia - Science | AAAS
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Tension modulates actin filament polymerization mediated by formin and profilin - PNAS
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Mechanism of actin filament branch formation by Arp2/3 complex revealed by a high-resolution cryo-EM structureof the branch junction - PNAS
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Formin and capping protein together embrace the actin filament in a ménage à trois - Nature
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Pathway of actin filament branch formation by Arp2/3 complex revealed by single-molecule imaging - PNAS
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Identification of Actin Filament-Associated Proteins in Giardia lamblia | Microbiology Spectrum - ASM Journals
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Steps of actin filament branch formation by Arp2/3 complex investigated with coarse-grained molecular dynamics - Frontiers
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Structural basis of thymosin-β4/profilin exchange leading to actin filament polymerization - PNAS
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Single-molecule imaging and kinetic analysis of cooperative cofilin–actin filament interactions - PNAS
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MYB52 negatively regulates ADF9-meditated actin filament bundling in Arabidopsis pavement cell morphogenesis - Wiley Online Library
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Mechanism of actin filament nucleation by the bacterial effector VopL - Nature
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Role of Active Contraction and Tropomodulins in Regulating Actin Filament Length and Sarcomere Structure in Developing Zebrafish Skeletal Muscle - Frontiers
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Isoform diversity in the Arp2/3 complex determines actin filament dynamics - Nature
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Structural characterization of a capping protein interaction motif defines a family of actin filament regulators - Nature
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Single-molecule visualization of a formin-capping protein ‘decision complex’ at the actin filament barbed end - Nature
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Dimeric WH2 domains in Vibrio VopF promote actin filament barbed-end uncapping and assisted elongation - Nature
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Identification of an ATP-controlled allosteric switch that controls actin filament nucleation by Arp2/3 complex - Nature
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A new twist in actin filament nucleation - Nature
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Mechanism of actin filament nucleation by Vibrio VopL and implications for tandem W domain nucleation - Nature
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EHBP1 Is Critically Involved in the Dendritic Arbor Formation and Is Coupled to Factors Promoting Actin Filament Formation - Journal of Neuroscience
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Rotational Movement of the Formin mDia1 Along the Double Helical Strand of an Actin Filament - Science | AAAS
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Dynamic polymorphism of single actin molecules in the actin filament - Nature
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CaMKIIβ binding to stable F-actin in vivo regulates F-actin filament stability - PNAS
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Structural Biologists Reveal Mysteries of Actin Filament Polarity - Technology Networks
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CaMKIIβ binding to stable F-actin in vivo regulates F-actin filament stability - PNAS
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Actin Cytoskeleton: Missing link for intracellular bacterial motility? - ScienceDirect.com
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Tropomodulins: Pointed-end capping proteins that regulate actin filament architecture in diverse cell types - Wiley Online Library
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A Mechanism for Adding the First Link in a Nascent Actin Filament Chain - PLOS
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Structural basis of actin filament nucleation and processive capping by a formin homology 2 domain - Nature
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Persistent inhibition of pore-based cell migration by sub-toxic doses of miuraenamide, an actin filament stabilizer - Nature
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CLIP-170 microtuble found to bind tightly to formins to accelerate actin filament elongation - Phys.org
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Formin' actin filament bundles - Nature
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Cryo-electron tomography structure of Arp2/3 complex in cells reveals new insights into the branch junction - Nature
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Cofilin promotes rapid actin filament turnover in vivo - Nature
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How Actin Filaments Doff Their Pi Cap - PLOS
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Multicomponent regulation of actin barbed end assembly by twinfilin, formin and capping protein - Nature
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The Arp2/3 complex nucleates actin filament branches from the sides of pre-existing filaments - Nature
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Nuclear actin filaments are not formed in the DNA-damaged DOs. - PLOS
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A single myosin head moves along an actin filament with regular steps of 5.3 nanometres - Nature
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Tropomyosin concentration but not formin nucleators mDia1 and mDia3 determines the level of tropomyosin incorporation into actin filaments | Scientific Reports - Nature
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Direct observation of dendritic actin filament networks nucleated by Arp2/3 complex and WASP/Scar proteins - Nature
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Bending forces and nucleotide state jointly regulate F-actin structure - Nature
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Actin filament uncapping localizes to ruffling lamellae and rocketing vesicles - Nature
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Cofilin promotes rapid actin filament turnover in vivo - Nature
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The intrinsic ability of AFAP-110 to alter actin filament integrity is linked with its ability to also activate cellular tyrosine kinases - Nature
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Quantifying cytoskeletal organization from optical microscopy data - Frontiers
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Computing on actin bundles network - Nature
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A Role of Actin Filament in Synaptic Transmission and Long-Term Potentiation - Journal of Neuroscience
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A Role of Actin Filament in Synaptic Transmission and Long-Term Potentiation - Journal of Neuroscience
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Stop or go: The cell maintains its fine motility balance with the help of tropomodulin - EurekAlert!
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ILK mediates actin filament rearrangements and cell migration and invasion through PI3K/Akt/Rac1 signaling - Nature
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The functions of actin-binding proteins are regulated by the flexibility and specific helical twists of actin filaments - Asia Research News |
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How Leiomodin and Tropomodulin use a common fold for different actin assembly functions - Nature
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High Temporal Resolution 3D Live-Cell Imaging of Budding Yeast Meiosis Defines Discontinuous Actin/Telomere-Mediated Chromosome Motion, Correlated Nuclear Envelope Deformation and Actin Filament Dynamics - Frontiers
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Formins direct Arp2/3-independent actin filament assembly to polarize cell growth in yeast - Nature
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A small molecule inhibitor of tropomyosin dissociates actin binding from tropomyosin-directed regulation of actin dynamics - Nature
Why This Topic Is Trending
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