Why is "Activation loop" trending?

Search Interest Perspective

• Ruxolitinib mediated paradoxical JAK2 hyperphosphorylation is due to the protection of activation loop tyrosines from phosphatases | Leukemia - Nature
• PKD autoinhibition in trans regulates activation loop autophosphorylation in cis - PNAS
• Accumulation of JAK activation loop phosphorylation is linked to type I JAK inhibitor withdrawal syndrome in myelofibrosis - Science | AAAS
• An allosteric switch between the activation loop and a c-terminal palindromic phospho-motif controls c-Src function - Nature
• Activation loop phosphorylation of a non-RD receptor kinase initiates plant innate immune signaling - PNAS
• The activation loop of PIP5K functions as a membrane sensor essential for lipid substrate processing - Science | AAAS
• A secondary RET mutation in the activation loop conferring resistance to vandetanib - Nature
• Activation loop dynamics are controlled by conformation-selective inhibitors of ERK2 - PNAS
• The activation loop of PIP5K functions as a membrane sensor essential for lipid substrate processing - Science | AAAS
• Characterization of RIPK3-mediated phosphorylation of the activation loop of MLKL during necroptosis - Nature
• Activation loop dynamics are controlled by conformation-selective inhibitors of ERK2 - PNAS
• SPRTN protease and checkpoint kinase 1 cross-activation loop safeguards DNA replication - Nature
• An Allosteric Cross-Talk Between the Activation Loop and the ATP Binding Site Regulates the Activation of Src Kinase - Nature
• Defining a new nomenclature for the structures of active and inactive kinases - PNAS
• Structural and dynamic insights into the energetics of activation loop rearrangement in FGFR1 kinase - Nature
• The SH2 domain of Abl kinases regulates kinase autophosphorylation by controlling activation loop accessibility - Nature
• FoxM1 drives ADAM17/EGFR activation loop to promote mesenchymal transition in glioblastoma - Nature
• Activation of RSK by phosphomimetic substitution in the activation loop is prevented by structural constraints - Nature
• Next-generation sequencing with a myeloid gene panel in core-binding factor AML showed KIT activation loop and TET2 mutations predictive of outcome - Nature
• Heterotrimer-independent regulation of activation-loop phosphorylation of Snf1 protein kinase involves two protein phosphatases - PNAS
• Regulation of the p300 HAT domain via a novel activation loop - Nature
• Transitions to catalytically inactive conformations in EGFR kinase - PNAS
• Evolutionary sequence and structural basis for the distinct conformational landscapes of Tyr and Ser/Thr kinases - Nature
• A novel FLT3 activation loop mutation N841K in acute myeloblastic leukemia - Nature
• A secondary RET mutation in the activation loop conferring resistance to vandetanib through allosteric effects - ncc.go.jp
• The cyclolignan PPP induces activation loop-specific inhibition of tyrosine phosphorylation of the insulin-like growth factor-1 receptor. Link to the phosphatidyl inositol-3 kinase/Akt apoptotic pathway | Oncogene - Nature
• Protein kinase D complexes with C-Jun N-terminal kinase via activation loop phosphorylation and phosphorylates the C-Jun N-terminus - Nature
• Structural basis for the impact of phosphorylation on the activation of plant receptor-like kinase BAK1 - Nature