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Acute basophilic leukemia (ABL) is a very rare & clinically aggressive subtype of acute myeloid leukemia (AML) designated by the WHO as a distinct entity within the subcategory of AML, Not Otherwise Specified (NOS), which accounts for roughly 4-5% of all "acute non-lymphocytic" cases of leukemia. ABL can be either primary (sporadic) or secondary to an existing bone marrow neoplasm. In either case, the disease is characterized by rapid proliferation of abnormal basophils & immature blasts in the bone marrow and peripheral blood. This process interferes with normal blood cell production, giving rise to classic symptoms of AML & ultimately bone marrow failure. Given the role of basophils in coordinating histamine release during inflammatory reactions, those with ABL also typically experience symptoms of hyper-histaminemia which can manifest cutaneously & within the gastrointestinal tract.
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