Why is "Adenylosuccinate" trending?
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Trend Analysis
- Ranking position: #
- Date: 2026-03-12 19:55:14
This topic has appeared in the trending rankings 1 time(s) in the past year. While it does not trend frequently, its appearance suggests a renewed or concentrated surge of public interest.
Based on Wikipedia pageviews and search interest, this topic gained significant attention on the selected date.
Trend Insight
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Wikipedia Overview
Adenylosuccinate, also known as succinyl-adenosine monophosphate (S-AMP), is an intermediate in the interconversion of purine nucleotides inosine monophosphate (IMP) and adenosine monophosphate (AMP). The enzyme adenylosuccinate synthase carries out the reaction of IMP to S-AMP in a 2 step mechanism, requiring the input of energy from a phosphoanhydride bond from the hydrolysis of guanosine triphosphate (GTP) first, followed by the addition of aspartate. This reaction needs Mg2+, and is competitively inhibited by the subsequent product AMP in a negative feedback mechanism. GTP, the product of another pathway from IMP, is used instead of adenosine triphosphate (ATP) as the phosphate source. The enzyme adenylosuccinate lyase carries out the reaction removing the carbon skeleton from S-AMP attached from aspartate, forming AMP and fumarate. The pathway from IMP to AMP is present across various prokaryotes and eukaryotes, and is linked to various diseases. S-AMP has been observed to stimulate insulin production.
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Search Interest Perspective
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Adenylosuccinate Synthase 1 Deficiency Improves Energy Metabolism by Promoting Adipose Tissue Re-esterification via Glycerol Kinase Upregulation - Wiley
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Tracing brain chemistry across humanity’s family tree - EurekAlert!
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Enzyme unique to modern humans may have given us an evolutionary edge, research finds - CNN
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Molecular comparison of Neanderthal and Modern Human adenylosuccinate lyase - Nature
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Genetic mutation in key enzyme may explain why humans survived while Neanderthals went extinct - Archaeology News Online Magazine
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This Small Tweak To Brain Chemistry May Have Given Homo Sapiens The Competitive Edge - IFLScience
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Prolyl hydroxylase substrate adenylosuccinate lyase is an oncogenic driver in triple negative breast cancer - Nature
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The Mysterious Gene That Could Explain Why Humans Beat Neanderthals to Survival - Indian Defence Review
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Scientists Discover a New Genetic Mutation That Distinguishes Modern Humans From Neanderthals - SciTechDaily
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First Streptococcus pyogenes Signature-Tagged Mutagenesis Screen Identifies Novel Virulence Determinants - ASM Journals
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Electroclinical features and phenotypic differences in adenylosuccinate lyase deficiency: Long-term follow-up of seven patients from four families and appraisal of the literature - Wiley Online Library
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'It was the perfect time' - Make-A-Wish gives teen home sensory room - Newstalk
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Autism spectrum disorder in adults: clinical features and the role of the psychiatrist - Cambridge University Press & Assessment
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Newly Identified Biochemical Pathway Could Be Target for Insulin Control | Newswise - Newswise
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Misleading behavioural phenotype with adenylosuccinate lyase deficiency - Nature
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From the Director of Graduate Studies - University of Delaware
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Discovery of Genetic Mutation That Separates Humans and Neanderthals - Ancient Origins
Why This Topic Is Trending
This topic has recently gained attention due to increased public interest. Search activity and Wikipedia pageviews suggest growing global engagement.
Search Interest & Related Topics
Search interest data over the past 12 months indicates that this topic periodically attracts global attention. Sudden spikes often correlate with major news events, public statements, or geopolitical developments.