Why is "Adrenomedullin" trending?
Latest news, Wikipedia summary, and trend analysis.
Trend Analysis
- Ranking position: #
- Date: 2026-03-29 07:02:55
This topic has appeared in the trending rankings 1 time(s) in the past year. While it does not trend frequently, its appearance suggests a renewed or concentrated surge of public interest.
Based on Wikipedia pageviews and search interest, this topic gained significant attention on the selected date.
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Wikipedia Overview
Adrenomedullin (ADM) is a peptide hormone that plays an important role in various physiological processes throughout the human body. Initially discovered in 1993 from a pheochromocytoma, a tumor of the adrenal medulla, this 52-amino acid peptide is now recognized for its diverse effects, including vasodilation, regulation of blood pressure, and maintenance of the vascular system. ADM is widely expressed in tissues and also found in the circulation, exerting its influence on the cardiovascular, lymphatic, and endocrine systems, as well as demonstrating anti-inflammatory and tissue-protective properties.
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Trending Topic Today
Search Interest Perspective
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CGRP-related neuropeptide adrenomedullin 2 promotes tissue-protective ILC2 responses and limits intestinal inflammation - Nature
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Adrenomedullin orchestrates treatment resistance in hepatocellular carcinoma via immune microenvironment remodeling - Frontiers
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Kinetics of adrenomedullin pathway activation in a porcine sepsis model and a human cohort of sepsis and septic shock - Nature
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Targeting the adrenomedullin pathway may be a potential therapy for liver failure - News-Medical
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Adrenomedullin as an immunomodulator of CD14+MerTK+ circulating monocytes in liver failure syndromes - EurekAlert!
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Clinical Potential of Adrenomedullin Signaling in the Cardiovascular System - American Heart Association Journals
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Effect of Adrenomedullin on Migraine-Like Attacks in Patients With Migraine - Neurology® Journals
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Adrenomedullin production by adult cardiac fibroblasts via NF-κB/STAT6 signaling enhances post-infarction lymphangiogenesis and cardiac repair - Nature
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Adrenomedullin/FOXO3 enhances sunitinib resistance in clear cell renal cell carcinoma by inhibiting FDX1 expression and cuproptosis - Wiley
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The heart of the matter: modulating therapeutic effects of adrenomedullin in cardiogenic shock - The Lancet
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Adrenomedullin 2/Intermedin Exerts Cardioprotective Effects by Regulating Cardiomyocyte Mitochondrial Function - American Heart Association Journals
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Adrenomedullin and Adrenomedullin-Targeted Therapy As Treatment Strategies Relevant for Sepsis - Frontiers
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Breast cancer cell-derived adrenomedullin confers cancer-associated adipose remodeling through the cAMP/Creb1/Zeb1 axis - Nature
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Lack of adrenomedullin in mouse endothelial cells results in defective angiogenesis, enhanced vascular permeability, less metastasis, and more brain damage - Nature
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Adrenomedullin-CALCRL axis controls relapse-initiating drug tolerant acute myeloid leukemia cells - Nature
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Sandwich immunoassay for adrenomedullin precursor and its practical application - Nature
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Effect of adrenomedullin on obesity-related hypertension - Nature
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Adrenomedullin alleviates the pyroptosis of Leydig cells by promoting autophagy via the ROS–AMPK–mTOR axis - Nature
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Plasma bioactive adrenomedullin predicts mortality and need for dialysis in critical COVID-19 | Scientific Reports - Nature
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Impact of adrenomedullin on mitochondrial respiratory capacity in human adipocyte | Scientific Reports - Nature
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Mid-regional pro-adrenomedullin: A rapid sepsis biomarker for diagnosing spontaneous bacterial peritonitis in cirrhosis - Wiley Online Library
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Inhibition of Endothelin Production by Adrenomedullin in Vascular Smooth Muscle Cells | Hypertension - American Heart Association Journals
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Adrenomedullin Safe to Treat Ischemic Stroke, May Lead to Improved Outcomes - NeurologyLive
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Pro-adrenomedullin as an independent predictive biomarker for heart failure in atrial fibrillation and flutter - Wiley Online Library
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Oocyte-specific disruption of adrenomedullin 2 gene enhances ovarian follicle growth after superovulation - Frontiers
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Mid-regional pro-adrenomedullin is a novel biomarker for arterial stiffness as the criterion for vascular failure in a cross-sectional study - Nature
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Postoperative bioactive adrenomedullin is associated with the onset of ARDS and adverse outcomes in patients undergoing open thoracoabdominal aortic surgery - Nature
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Small molecules related to adrenomedullin reduce tumor burden in a mouse model of colitis-associated colon cancer - Nature
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Small GTPase Rap1A/B Is Required for Lymphatic Development and Adrenomedullin-Induced Stabilization of Lymphatic Endothelial Junctions - American Heart Association Journals
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Degranulation of mast cells induced by gastric cancer-derived adrenomedullin prompts gastric cancer progression - Nature
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Obesity-Linked Hormone Adrenomedullin Disrupts Insulin Signaling - Genetic Engineering and Biotechnology News
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Adrenomedullin hormone as key driver of insulin resistance in obesity-linked type 2 diabetes - News-Medical
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Loss of cortactin causes endothelial barrier dysfunction via disturbed adrenomedullin secretion and actomyosin contractility | Scientific Reports - Nature
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Modulation of osteoclastogenesis through adrenomedullin receptors on osteoclast precursors: initiation of differentiation by asymmetric cell division - Nature
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Adrenomedullin hormone contributes to insulin resistance in obesity-associated type 2 diabetes - News-Medical
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If insulin can’t get into tissues, it can’t act - ACS Publications
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Hemodynamic and hormonal effects of exogenous adrenomedullin administration in humans and relationship to insulin resistance - Nature
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Adrenomedullin and tumour angiogenesis - British Journal of Cancer - Nature
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The hypoxia target adrenomedullin is aberrantly expressed in multiple myeloma and promotes angiogenesis - Nature
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Relationship Between Serum Concentration of Adrenomedullin and Myocardial Ischemic T Wave Changes in Patients With Lung Cancer - Frontiers
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PulmoBind Imaging Measures Reduction of Vascular Adrenomedullin Receptor Activity with Lack of effect of Sildenafil in Pulmonary Hypertension - Nature
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Adrenomedullin disulfide bond mimetics uncover structural requirements for AM1 receptor activation - Wiley Online Library
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Adrenomedullin gene expression differences in mice do not affect blood pressure but modulate hypertension-induced pathology in males - PNAS
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The association of midregional pro-adrenomedullin (MR-proADM) at ICU admission and fluid overload in patients post elective cardiac surgery - Nature
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Adrenomedullin promotes angiogenesis in epithelial ovarian cancer through upregulating hypoxia-inducible factor-1α and vascular endothelial growth factor - Nature
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Galanin and Adrenomedullin Plasma Responses During Artificial Gravity on a Human Short-Arm Centrifuge - Frontiers
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Bioactive adrenomedullin for assessment of venous congestion in heart failure - Wiley Online Library
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Adrenomedullin protects Leydig cells against lipopolysaccharide-induced oxidative stress and inflammatory reaction via MAPK/NF-κB signalling pathways - Nature
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Pro‐adrenomedullin associates with congestion in acute heart failure patients - Wiley Online Library
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Lack of adrenomedullin in the mouse brain results in behavioral changes, anxiety, and lower survival under stress conditions - PNAS
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Adrenomedullin peptides and precursor levels in relation to haemodynamics and prognosis after heart transplantation - Wiley Online Library
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The Role of Ubiquitination and Hepatocyte Growth Factor-Regulated Tyrosine Kinase Substrate in the Degradation of the Adrenomedullin Type I Receptor - Nature
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Adrenomedullin, transcriptionally regulated by vitamin D receptors, alleviates atherosclerosis in mice through suppressing AMPK-mediated endothelial ferroptosis - Wiley Online Library
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Intermedin/adrenomedullin 2 polypeptide promotes adipose tissue browning and reduces high-fat diet-induced obesity and insulin resistance in mice - Nature
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Protective effects of statin on cardiac fibrosis and apoptosis in adrenomedullin-knockout mice treated with angiotensin II and high salt loading - Nature
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Bayer ends respiratory distress drug development in latest phase 2 cleanout - Fierce Biotech
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Precursor proadrenomedullin influences cardiomyocyte survival and local inflammation related to myocardial infarction - PNAS
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Aldosterone antisecretagogue and antihypertensive actions of adrenomedullin in patients with primary aldosteronism - Nature
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If insulin can’t get into tissues, it can’t act - Chemical & Engineering News
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Hormone Therapy May Prevent Lung Damage in Premature Infants - respiratory-therapy.com
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Adrenomedullin reduces food intake through interactions with satiety-related hypothalamic nuclei in chicks - Wiley
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Fluorescently labeled adrenomedullin allows real-time monitoring of adrenomedullin receptor trafficking in living cells - Wiley Online Library
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Association of a functional polymorphism in the adrenomedullin gene ( ADM ) with response to paroxetine - Nature
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Proximity interactome of lymphatic VE-cadherin reveals mechanisms of junctional remodeling and reelin secretion - Nature
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First use of vasoprotective antibody in cardiogenic shock - healthcare-in-europe.com
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Good microcirculation indicates increased lifespan - EurekAlert!
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Adrenomedullin promotes formation of xenografted endometrial tumors by stimulation of autocrine growth and angiogenesis - Nature
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Association between MR-proADM concentration and treatment intensity of antihypertensive agents in chronic kidney disease patients with insufficient blood pressure control - Nature
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Determining the Effects of Differential Expression of GRKs and β-arrestins on CLR-RAMP Agonist Bias - Frontiers
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Adrenomedullin inhibits hypoxic cell death by upregulation of Bcl-2 in endometrial cancer cells: a possible promotion mechanism for tumour growth - Nature
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Endosomal signaling of the receptor for calcitonin gene-related peptide mediates pain transmission - PNAS
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Adrenomed reveals MOA of sepsis antibody - European Biotechnology Magazine
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Proadrenomedullin as a prognostic marker in neonatal sepsis - Nature
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Transcriptional regulation of the CRLR gene in human microvascular endothelial cells by hypoxia - Nikitenko - 2003 - Wiley
Why This Topic Is Trending
This topic has recently gained attention due to increased public interest. Search activity and Wikipedia pageviews suggest growing global engagement.
Search Interest & Related Topics
Search interest data over the past 12 months indicates that this topic periodically attracts global attention. Sudden spikes often correlate with major news events, public statements, or geopolitical developments.