Why is "Adult T-cell leukemia/lymphoma" trending?
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Trend Analysis
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- Date: 2026-03-23 03:59:42
This topic has appeared in the trending rankings 1 time(s) in the past year. While it does not trend frequently, its appearance suggests a renewed or concentrated surge of public interest.
Based on Wikipedia pageviews and search interest, this topic gained significant attention on the selected date.
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Wikipedia Overview
Adult T-cell leukemia/lymphoma is a rare cancer of the immune system's T-cells caused by human T cell leukemia/lymphotropic virus type 1 (HTLV-1). All ATL cells contain integrated HTLV-1 provirus further supporting that causal role of the virus in the cause of the neoplasm. A small number of HTLV-1 individuals progress to develop ATL with a long latency period between infection and ATL development. ATL is categorized into four subtypes: acute, smoldering, lymphoma-type, and chronic. Acute and lymphoma-type are known to particularly be aggressive with poorer prognosis.
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Search Interest Perspective
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Prognostic impact of organ involvement in aggressive adult T-cell leukemia/lymphoma: definition of risk organ and proposal of a prognostic index | Blood Cancer Journal - Nature
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Emerging Sub-Segments Transforming the Adult T-Cell Leukemia/Lymphoma Treatment Market Landscape - openPR.com
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A review of cutaneous manifestations of HTLV-associated adult T-cell leukemia/lymphoma - Frontiers
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Rare Peritoneal Involvement in Adult T-Cell Leukemia/Lymphoma: A Diagnostic Conundrum - Cureus
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Outcomes of patients with HTLV-1 adult T-cell leukemia/lymphoma (ATLL) after allogeneic SCT: results of the EBMT LWP | Bone Marrow Transplantation - Nature
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Hypercalcemia and Flower Cells on Peripheral Smear Revealing Human T-lymphotropic Virus Type 1 (HTLV-1)-Associated Adult T-cell Leukemia/Lymphoma - Cureus
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JunB–HBZ nuclear translocation by TGF-β is a key driver in HTLV-1-mediated leukemogenesis - PNAS
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Rapid Progression of Adult T-Cell Leukemia–Lymphoma after PD-1 Inhibitor Therapy - NEJM
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Location Matters: US Patients With Adult T-Cell Leukemia/Lymphoma Have Distinct Clinical, Genetic Features - OncLive
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Clathrin-associated SCYL2 contributes to the activation of PI3K/AKT signaling and tumorigenesis through PTEN phosphorylation in adult T-cell leukemia/lymphoma - Nature
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Human T-cell leukemia virus type 1: oncogenic potential and vaccine development strategies - Frontiers
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Chimeric SF-25 monoclonal antibody as a targeted therapy for SLC3A2 in adult T-cell leukemia/lymphoma - Nature
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Biomarkers and Preclinical Models for Adult T-Cell Leukemia-Lymphoma Treatment - Frontiers
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Bidirectional anti-tumor and immunological strategies by targeting GARP–TGF-β axis in adult T-cell leukemia/lymphoma - Nature
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Combination of artesunate and ruxolitinib suppresses T cell leukemia/lymphoma proliferation via the JAK STAT pathway - Nature
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A comprehensive assessment using multiple factors based on HAS-Flow analysis predicts ATL development and progression - Nature
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CARD11 mutation and HBZ expression induce lymphoproliferative disease and adult T-cell leukemia/lymphoma - Nature
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Primary cells from patients with adult T cell leukemia/lymphoma depend on HTLV-1 Tax expression for NF-κB activation and survival - Nature
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Chronological genome and single-cell transcriptome integration characterizes the evolutionary process of adult T cell leukemia-lymphoma - Nature
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An HuR mutant, HuR-V225I, identified in adult T-cell Leukemia/Lymphoma, alters the pro-apoptotic function of HuR - Nature
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Valemetostat Shows Promising Efficacy in Relapsed/Refractory Adult T-cell Leukemia/Lymphoma - Hematology Advisor
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Treatment of relapsed aggressive adult T-cell leukemia/lymphoma after allogeneic hematopoietic stem cell transplantation with mogamulizumab followed by lenalidomide - Nature
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Co-stimulatory and immune checkpoint molecules are important in the tumor microenvironment of Hodgkin-like adult T-cell leukemia/lymphoma - Haematologica
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Integrated molecular analysis of adult T cell leukemia/lymphoma - Nature
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Full-length HLA sequencing in adult T cell leukemia–lymphoma uncovers multiple gene alterations - Nature
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Mogamulizumab versus investigator choice in relapsed/refractory adult T-cell leukemia/lymphoma: all four one or none for all? - Haematologica
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A new diagnostic algorithm using biopsy specimens in adult T-cell leukemia/lymphoma: combination of RNA in situ hybridization and quantitative PCR for HTLV-1 - Nature
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Anti-HTLV-1 immunity combined with proviral load as predictive biomarkers for adult T-cell leukemia-lymphoma - Wiley Online Library
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Cord blood is a suitable donor source of allogeneic hematopoietic cell transplantation for adult T-cell leukemia-lymphoma: a nationwide retrospective study - Nature
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Impact of HLA-mismatched unrelated transplantation in patients with adult T-cell leukemia/lymphoma - Nature
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The genomic landscape of adult T cell leukemia/lymphoma - Nature
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5-aminolevulinic acid-mediated photodynamic therapy can target aggressive adult T cell leukemia/lymphoma resistant to conventional chemotherapy - Nature
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Adult T-cell leukemia/lymphoma can be indistinguishable from other more common T-cell lymphomas. The University of Miami experience with a large cohort of cases - Nature
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Integrated molecular and immunological features of human T-lymphotropic virus type 1 infection and disease progression to adult T-cell leukaemia or lymphoma - The Lancet
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Japan Green Lights Valemetostat Tosilate for Relapsed/Refractory Adult T-cell Leukemia/Lymphoma - OncLive
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Japanese Approval Sought for Valemetostat in Relapsed/Refractory Adult T-Cell Leukemia/Lymphoma - OncLive
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Molecular Hallmarks of Adult T Cell Leukemia - Frontiers
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Adult T-Cell Leukemia/Lymphoma With Extranodal Involvement of the Hypopharynx - Cureus
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Human T-cell leukaemia virus type I and adult T-cell leukaemia-lymphoma - The Lancet
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Adult T-Cell Leukemia: A Review of Epidemiological Evidence - Frontiers
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Human T-cell Lymphotropic Virus Type 1 (HTLV-1)-Associated Adult T-cell Leukemia/Lymphoma in a Patient Previously Treated for Strongyloidiasis - Cureus
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Crusted (Norwegian) scabies as a strong marker of adult T-cell leukemia/lymphoma in HTLV-1 infection - Wiley Online Library
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Adult T‐cell leukemia/lymphoma - Wiley
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The relationship of FOXP3 expression and clinicopathological characteristics in adult T-cell leukemia/lymphoma - Nature
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HTLV-1-Mediated Epigenetic Pathway to Adult T-Cell Leukemia–Lymphoma - Frontiers
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The clinical benefit of acute GVHD depends on the age at transplantation in patients with adult T-cell leukemia–lymphoma on behalf of the ATL Working Group of the Japan Society for Transplantation and Cellular Therapy - Nature
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Targeted deep sequencing reveals clonal and subclonal mutational signatures in Adult T-cell leukemia/lymphoma and defines an unfavorable indolent subtype - Nature
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Adult T-Cell Lymphoma: Pharmacologic Management - Cancer Therapy Advisor
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Reversal of CYLD phosphorylation as a novel therapeutic approach for adult T-cell leukemia/lymphoma (ATLL) - Nature
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A case of adult T-cell leukemia/lymphoma presenting with erythema gyratum repens-like eruptions - Wiley Online Library
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Progress in Allogeneic Hematopoietic Cell Transplantation in Adult T-Cell Leukemia-Lymphoma - Frontiers
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Epidemiology and survival trend of adult T‐cell leukemia/lymphoma in the United States - Wiley
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Bayesian sparse regression for exposure–response analyses of efficacy and safety endpoints to justify the clinical dose of valemetostat for adult T-cell leukemia/lymphoma - Wiley
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A comparison of long-term outcomes by donor type in the era of post-transplantation cyclophosphamide for aggressive adult T-cell leukemia/lymphoma - Nature
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Natural history of adult T-cell leukemia/lymphoma and approaches to therapy - Nature
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Dual cytoplasmic and nuclear localization of HTLV-1-encoded HBZ protein is a unique feature of adult T-cell leukemia - Haematologica
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Overexpression of aberrant Wnt5a and its effect on acquisition of malignant phenotypes in adult T-cell leukemia/lymphoma (ATL) cells - Nature
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Treatment of Adult T-Cell Leukemia-Lymphoma with Zidovudine and Interferon Alfa - NEJM
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Hyposplenism in adult T‐cell leukemia/lymphoma - Wiley Online Library
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PD-1/PD-L1 expression in human T-cell leukemia virus type 1 carriers and adult T-cell leukemia/lymphoma patients - Nature
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Mature T-Cell leukemias: Challenges in Diagnosis - Frontiers
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Current Perspectives in Human T-Cell Leukemia Virus Type 1 Infection and Its Associated Diseases - Frontiers
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IFN-β induces greater antiproliferative and proapoptotic effects and increased p53 signaling compared with IFN-α in PBMCs of Adult T-cell Leukemia/Lymphoma patients - Nature
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Dose-adjusted EPOCH chemotherapy with bortezomib and raltegravir for human T-cell leukemia virus-associated adult T-cell leukemia lymphoma - Nature
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Long-term follow-up of patients with ATL after autologous stem cell transplantation - Nature
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What to Know About Adult T-cell Leukemia (ATL) - Healthline
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Treatment of Adult T-Cell Leukemia–Lymphoma with a Combination of Interferon Alfa and Zidovudine - NEJM
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Clinicopathological significance of CD28 overexpression in adult T‐cell leukemia/lymphoma - Wiley Online Library
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The tyrosine kinase KDR is essential for the survival of HTLV-1-infected T cells by stabilizing the Tax oncoprotein - Nature
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XPO1 inhibitors represent a novel therapeutic option in Adult T-cell Leukemia, triggering p53-mediated caspase-dependent apoptosis - Nature
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Alternative RNA splicing in cancer: what about adult T-cell leukemia? - Frontiers
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Whole genome CRISPR screening identifies molecular mechanisms of PD-L1 expression in Adult T-cell leukemia/lymphoma. - Physician's Weekly
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HTLV-1 bZIP factor suppresses TDP1 expression through inhibition of NRF-1 in adult T-cell leukemia - Nature
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Red Blood Cell Deformation and Progressive Anemia Following Therapeutic Intervention in Patients With Adult T-Cell Leukemia/Lymphoma - Cureus
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A transgenic mouse model of human T cell leukemia virus type 1-associated diseases - Frontiers
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Adult T‐Cell Leukemia/Lymphoma with CLL‐Like Morphology—A Case Report - Wiley Online Library
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Interplay between innate immunity and the viral oncoproteins Tax and HBZ in the pathogenesis and therapeutic response of HTLV-1 associated adult T cell leukemia - Frontiers
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Acute type adult T-cell leukemia cells proliferate in the lymph nodes rather than in peripheral blood - Nature
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Peripheral T-Cell Lymphomas: Incorporating New Developments in Diagnostics, Prognostication, and Treatment Into Clinical Practice-PART 2: ENKTL, EATL, Indolent T-Cell LDP of the GI Tract, ATLL, and Hepatosplenic T-Cell Lymphoma - CancerNetwork
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The Past, Present, and Future of a Human T-Cell Leukemia Virus Type 1 Vaccine - Frontiers
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Allogeneic transplantation for adult T-cell leukemia/lymphoma in adolescent and young adults and young patients: A nationwide retrospective study by the ATL working group of the Japan society for transplantation and cellular therapy - Wiley Online Library
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Epidemiology of HTLV-1 Infection and ATL in Japan: An Update - Frontiers
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Bone marrow versus peripheral blood stem cells as the graft source for allogeneic transplantation from HLA-matched relative donors in adult T-cell leukemia/lymphoma: A nationwide retrospective study by the ATL working group of the Japanese Society for Tra - Nature
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HTLV-1 persistence and leukemogenesis: A game of hide-and-seek with the host immune system - Frontiers
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Hematological changes in human lymphotropic-T virus type 1 carriers - Frontiers
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Human T-cell lymphotropic virus type 1 and its oncogenesis - Nature
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Lenalidomide treatment for recurrent adult T-cell leukemia/lymphoma after allogeneic hematopoietic cell transplantation - Wiley Online Library
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Clinical significance of CADM1/TSLC1/IgSF4 expression in adult T-cell leukemia/lymphoma - Nature
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New gene targets for treating adult blood cancer - healthcare-in-europe.com
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Valemetostat in Relapsed or Refractory Peripheral T-Cell Lymphoma - The ASCO Post
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HTLV-1 as a Model for Virus and Host Coordinated Immunoediting - Frontiers
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HTLV: It Is Time to Reach a Consensus on Its Nomenclature - Frontiers
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AACR 2017 | Overexpression of PD-L1 contributes to immune evasion of Adult T-Cell Leukemia/Lymphoma - Lymphoma Hub
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HTLV-1 Infection and Rheumatic Diseases - Frontiers
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Clinical and cytopathological characteristics of HTLV‐1+ hodgkin lymphoma - Kobata - 2020 - Cancer Medicine - Wiley Online Library
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Involvement of double-stranded RNA-dependent protein kinase and antisense viral RNA in the constitutive NFκB activation in adult T-cell leukemia/lymphoma cells - Nature
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Quantification of T cell clonality in human T cell leukaemia virus type-1 carriers can detect the development of adult T cell leukaemia early | Blood Cancer Journal - Nature
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The Road to HTLV-1-Induced Leukemia by Following the Subcellular Localization of HTLV-1-Encoded HBZ Protein - Frontiers
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University of the Ryukyus and NEC discover a novel diagnostic biomarker for acute adult T-cell leukemia/lymphoma - NEC Global
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Improved outcome of adult T cell leukemia/lymphoma with allogeneic hematopoietic stem cell transplantation - Nature
Why This Topic Is Trending
This topic has recently gained attention due to increased public interest. Search activity and Wikipedia pageviews suggest growing global engagement.
Search Interest & Related Topics
Search interest data over the past 12 months indicates that this topic periodically attracts global attention. Sudden spikes often correlate with major news events, public statements, or geopolitical developments.