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Biological risk assessment representation
An adverse outcome pathway (AOP) is structured representation of biological events leading to adverse effects and is considered relevant to risk assessment. The AOP links in a linear way existing knowledge along one or more series of causally connected key events (KE) between two points — a molecular initiating event (MIE) and an adverse outcome (AO) that occur at a level of biological organization relevant to risk assessment. The linkage between the events is described by key event relationships (KER) that describe the causal relationships between the key events.
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Adverse Outcome Pathway Framework Facilitates Use of Human Information to Increase Understanding of COVID-19 - Physicians Committee for Responsible Medicine
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The 2021 update of the EPA’s adverse outcome pathway database - Scientific Data - Nature
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Adverse Outcome Pathway on Aryl hydrocarbon receptor activation leading to early life stage mortality via sox9 repression induced impeded craniofacial development - OECD
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Bridging the Gap Between Human Toxicology and Ecotoxicology Under One Health Perspective by a Cross-Species Adverse Outcome Pathway Network for Reproductive Toxicity - Wiley Online Library
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Development of a data-driven approach to Adverse Outcome Pathway network generation: a case study on the EATS-modalities - Frontiers
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Adverse outcome pathway networks I: Development and applications - Wiley Online Library
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Building and Applying Quantitative Adverse Outcome Pathway Models for Chemical Hazard and Risk Assessment - Wiley Online Library
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JAK/STAT and TGF-ß activation as potential adverse outcome pathway of TiO - Nature
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