Why is "Aggrecan" trending?

Search Interest Perspective

• Diverse Traits in Chinese Aggrecan Gene Short Stature - Bioengineer.org
• A plastic aggrecan barrier modulated by peripheral energy state gates metabolic signal access to arcuate neurons - Nature
• Electromechanobiology of Cartilage and Osteoarthritis: A Tribute to Alan Grodzinsky on his 75th Birthday [Internet]. - National Institutes of Health (.gov)
• Aggrecan Directs Extracellular Matrix-Mediated Neuronal Plasticity - Journal of Neuroscience
• Two new papers advance aggrecan deficiency research - Children's National
• Impact of Growth Hormone Treatment in Children From an Extended Family With ACAN -Related Short Stature - Wiley Online Library
• Mice Exhibit Altered Aggrecan Proteolytic Profiles That Correlate With Ascending Aortic Anomalies - American Heart Association Journals
• Juvenile Hippocampal CA2 Region Expresses Aggrecan - Frontiers
• Microglial depletion increases aggrecan and hyaluronan levels in the diffuse and aggregated extracellular matrix of the mouse brain - Nature
• Tracing the history of aggrecan gene mutations - Children's National
• Synovial mesenchymal progenitor derived aggrecan regulates cartilage homeostasis and endogenous repair capacity - Nature
• Catabolic mediators from TLR2-mediated proteoglycan aggrecan peptide-stimulated chondrocytes are reduced by Lactobacillus -conditioned media - Nature
• Differential impacts of germline and adult aggrecan knockout in PV+ neurons on perineuronal nets and PV+ neuronal function - Nature
• Differential tissue specific, temporal and spatial expression patterns of the Aggrecan gene is modulated by independent enhancer elements | Scientific Reports - Nature
• Evaluation of a new variant in the aggrecan gene potentially associated with chondrodysplastic dwarfism in Miniature horses - Nature
• Differential transactivation of the upstream aggrecan enhancer regulated by PAX1/9 depends on SOX9-driven transactivation - Nature
• The matrix proteins aggrecan and fibulin-1 play a key role in determining aortic stiffness - Nature
• Aggrecan and chondroitin-6-sulfate abnormalities in schizophrenia and bipolar disorder: a postmortem study on the amygdala | Translational Psychiatry - Nature
• Novel missense ACAN gene variants linked to familial osteochondritis dissecans cluster in the C-terminal globular domain of aggrecan - Nature
• LOXL2 promotes aggrecan and gender-specific anabolic differences to TMJ cartilage - Nature
• Identification of a novel heterozygous mutation of the Aggrecan gene in a family with idiopathic short stature and multiple intervertebral disc herniation - Nature
• Update on Perineuronal Net Staining With Wisteria floribunda Agglutinin (WFA) - Frontiers
• Correction: NFATc2-rearranged sarcomas: clinicopathologic, molecular, and cytogenetic study of 7 cases with evidence of AGGRECAN as a novel diagnostic marker | Modern Pathology - Nature
• Genetic screening confirms heterozygous mutations in ACAN as a major cause of idiopathic short stature - Nature
• Sensory Deprivation Alters Aggrecan and Perineuronal Net Expression in the Mouse Barrel Cortex - Journal of Neuroscience
• Induced Chondrocyte Ablation Disrupts Articular Cartilage Homeostasis but Is Not a Driver of Degeneration - Wiley
• Monogenic Short Stature and the Promise of Identifying Genetic Etiologies: An Expert Interview - Endocrinology Advisor
• HB-GAM (pleiotrophin) reverses inhibition of neural regeneration by the CNS extracellular matrix - Nature
• Distinct effects of different matrix proteoglycans on collagen fibrillogenesis and cell-mediated collagen reorganization - Nature
• Sensory Deprivation Alters Aggrecan and Perineuronal Net Expression in the Mouse Barrel Cortex - Journal of Neuroscience
• First-of-its-kind trial boosts growth in children with rare disorders - Children's National
• Aggrecanase-selective tissue inhibitor of metalloproteinase-3 (TIMP3) protects articular cartilage in a surgical mouse model of osteoarthritis - Nature
• Identification of novel ACAN mutations in two Chinese families and genotype–phenotype correlation in patients with 74 pathogenic ACAN variations - Wiley Online Library
• ARISE II Underway to Evaluate Ascending Aorta Stent Graft for Endovascular Repair - Cleveland Clinic
• Vosoritide shows promise for children with certain genetic growth disorders - Children's National
• Isolation and characteristics of autoreactive T cells specific to aggrecan G1 domain from rheumatoid arthritis patients - Nature
• Acan downregulation in parvalbumin GABAergic cells reduces spontaneous recovery of fear memories - Nature
• BioMarin Pauses Dosing, Enrollment in 2 Voxzogo Studies After Safety Signal - BioSpace
• Association of cartilage metabolism biomarkers and 25(OH)D levels with muscle biomechanical functions in professional rowers and canoeists - Nature
• BioMarin discontinues dosing in certain Voxzogo trials after safety concern - Clinical Trials Arena
• M1-like macrophage contributes to chondrogenesis in vitro - Nature
• The Emerging Role of the ADAMTS Family in Vascular Diseases - American Heart Association Journals
• Lin Han, PhD, receives 2021 Kappa Delta Young Investigator Award for the study of cartilage function, regeneration and disease intervention in osteoarthritis - PR Newswire
• “Dancing Molecules” Regenerative Effects Might Be Universal across Tissue Types - Genetic Engineering and Biotechnology News
• Damaged Neocortical Perineuronal Nets Due to Experimental Focal Cerebral Ischemia in Mice, Rats and Sheep - Frontiers
• Distribution and postnatal development of chondroitin sulfate proteoglycans in the perineuronal nets of cholinergic motoneurons innervating extraocular muscles - Nature
• Could Fish Waste Prove a Good Source of a Popular Health Food Ingredient? - Technology Networks
• Vosoritide Boosts Growth in Several Short Stature Conditions - Medscape
• Tracing the History of ACAN Mutations (IMAGE) - EurekAlert!
• Autofluorescence Lifetime Reports Cartilage Damage in Osteoarthritis - Nature
• BioMarin stops mid-stage trials of bone disorder treatment - Reuters
• Cholesterol-induced LRP3 downregulation promotes cartilage degeneration in osteoarthritis by targeting Syndecan-4 - Nature
• Variable expressivity in a family with an aggrecanopathy - Denis - 2022 - Molecular Genetics & Genomic Medicine - Wiley Online Library
• The Spectrum of ACAN Gene Mutations in a Selected Chinese Cohort of Short Stature: Genotype-Phenotype Correlation - Frontiers
• Exosites in Hypervariable Loops of ADAMTS Spacer Domains control Substrate Recognition and Proteolysis - Nature
• Saccadic Palsy following Cardiac Surgery: Possible Role of Perineuronal Nets - PLOS
• Wiring up the visual system requires precise temporal control of axon terminations - Medical Xpress
• Exosite inhibition of ADAMTS-5 by a glycoconjugated arylsulfonamide - Nature
• Regulation of Perineuronal Nets in the Adult Cortex by the Activity of the Cortical Network - Journal of Neuroscience
• Boosting Brain Plasticity: A New Pathway for PTSD Therapy? - Neuroscience News
• Activation of α2A-adrenergic signal transduction in chondrocytes promotes degenerative remodelling of temporomandibular joint - Nature
• The “Loss” of Perineuronal Nets in Alzheimer's Disease: Missing or Hiding in Plain Sight? - Frontiers
• New research could help heal cartilage after trauma or sports injuries - Imperial College London