Why is "Agomelatine" trending?
Latest news, Wikipedia summary, and trend analysis.
Trend Analysis
- Ranking position: #
- Date: 2026-03-25 14:05:17
This topic has appeared in the trending rankings 1 time(s) in the past year. While it does not trend frequently, its appearance suggests a renewed or concentrated surge of public interest.
Based on Wikipedia pageviews and search interest, this topic gained significant attention on the selected date.
Trend Insight
This topic is not currently in the ranking.
Wikipedia Overview
Agomelatine, sold under the brand name Thymanax among others, is an atypical antidepressant most commonly used to treat major depressive disorder and generalized anxiety disorder. One review found that it is as effective as other antidepressants with similar discontinuation rates overall but fewer discontinuations due to side effects. Another review also found it was similarly effective to many other antidepressants.
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Trending Topic Today
Search Interest Perspective
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Seaport doses first subject in Phase I trial of GAD treatment - MSN
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Serotonin receptor 4 in the ventral CA3 regulates agomelatine-induced anxiolytic-like behaviors - Nature
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GlyphAgo for Treatment of Anxiety Shows Positive Phase 1 Topline Results - Psychiatric Times
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Sustained Remission in a Patient With Depression, Chronic Insomnia, and Ischemic Heart Disease Using a Combination of Agomelatine and Mirtazapine: A Case Report - Cureus
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Seaport Therapeutics Announces Positive Proof of Concept Topline Results from Ongoing Phase 1 Trial of GlyphAgo™ in Healthy Volunteers - Business Wire
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Seaport Therapeutics Advances Second Therapeutic Candidate into Clinical Development with Dosing of First Participant in Phase 1 Study of GlyphAgo™ (SPT-320) in Healthy Volunteers - BioSpace
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PureTech Founded Entity Seaport Therapeutics Announces Positive Proof of Concept Topline Results from Ongoing Phase 1 Trial of GlyphAgo™ in Healthy Volunteers - Yahoo Finance Singapore
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Antidepressants vary widely in their physical side effects, highlighting the need for personalized prescribing - Medical Xpress
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Fluoxetine and agomelatine mitigate anhedonic and hepatic changes in chronic restraint stress rat model - Nature
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Researchers call for update to antidepressant guidelines - The Pharmaceutical Journal
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Drug use evaluation: A two-year retrospective review of the effectiveness and tolerability of agomelatine versus mirtazapine in patients with depressive disorder - Wiley Online Library
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Unique Attributes of Agomelatine Might Renew Interest - Psychiatry Advisor
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Antidepressant Agomelatine Improves Sleep and Mood Disorders in Epilepsy - NeurologyLive
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PureTech Founded Entity Seaport Therapeutics Advances Second Therapeutic Candidate into Clinical Development with Dosing of First Participant in Phase 1 Study of GlyphAgo™ (SPT-320) in Healthy Volunteers - BioSpace
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Agomelatine alleviates palmitic acid-induced mouse oocyte meiosis defects by restoring mitochondrial function - Nature
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Seaport Therapeutics Presents New Preclinical Data on SPT-320 (Glyph Agomelatine) at the Society of Biological Psychiatry (SOBP) Annual Meeting - BioSpace
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Agomelatine Prevents Amyloid Plaque Deposition, Tau Phosphorylation, and Neuroinflammation in APP/PS1 Mice - Frontiers
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Antidepressants vary widely in physical side effects including weight gain - Pulse Today
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Not all antidepressants are alike: New study ranks side effects for first time - Gulf News
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Green synchronous spectrofluorimetric method for the simultaneous determination of agomelatine and venlafaxine in human plasma at part per billion levels - Nature
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Agomelatine efficacy and acceptability revisited: systematic review and meta-analysis of published and unpublished randomised trials - Cambridge University Press & Assessment
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Beyond SSRIs: How the Newest Antidepressants Work - Healthline
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Anti-depressant side effects review prompts call for guidelines update - Juta MedicalBrief
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Agomelatine for Sleep Measures in Obstructive Sleep Apnea - Docwire News
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Researchers Assessed Antidepressants by Side Effects and Found Some Big Differences - ZME Science
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Agomelatine Reduces Migraine Frequency 25mg Daily - Physician's Weekly
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Agomelatine Worsens Motor Function, Neuron Loss in Parkinson’s Rat Study - Parkinson's News Today
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Scaffold Hopping Toward Agomelatine: Novel 3, 4-Dihydroisoquinoline Compounds as Potential Antidepressant Agents - Nature
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Agomelatine in the treatment of obsesive-compulsive-disorder: Potential for clinical effectiveness: An 4-week, multicenter, randomized, placebo-controlled trial - Cambridge University Press & Assessment
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Effect of agomelatine on memory deficits and hippocampal gene expression induced by chronic social defeat stress in mice - Nature
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Effect of Agomelatine in the Chronic Mild Stress Model of Depression in the Rat - Nature
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Different antidepressants affect key physiological measures differently. - Psychology Today
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Agomelatine, the first melatonergic antidepressant: discovery, characterization and development - Nature
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EMA confirms positive benefit-risk for antidepressant Valdoxan/Thymanax (agomelatine) - European Medicines Agency (EMA)
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Case report: Hypnic headache responds to agomelatine–a potential prophylactic treatment option - Frontiers
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Mechanisms Contributing to the Phase-Dependent Regulation of Neurogenesis by the Novel Antidepressant, Agomelatine, in the Adult Rat Hippocampus | Neuropsychopharmacology - Nature
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Combination of agomelatine and bupropion for treatment-resistant depression: results from a chart review study including a matched control group - Wiley Online Library
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Antidepressants Compared and Ranked for Treatment of Major Depressive Disorder - Medical Professionals Reference
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Hippocampal and behavioral dysfunctions in a mouse model of environmental stress: normalization by agomelatine - Nature
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Agomelatine Treatment of Major Depressive Disorder in Parkinson's Disease: A Case Series - Psychiatry Online
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Activation of Melatonin Receptors Reduces Relapse-Like Alcohol Consumption - Nature
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Pipeline for New Antidepressants Flowing Slowly - Psychiatry Online
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Potentiation of Antidepressant Effects of Agomelatine and Bupropion by Hesperidin in Mice - Wiley Online Library
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Agomelatine cuts ocular pressure with glaucoma - Medical Xpress
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Tackling depression and poor sleep with one drug - The Conversation
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When depression drugs stop working - The Hippocratic Post
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Evidence-Based Pharmacotherapy of Anxiety Symptoms in Patients with Major Depressive Disorder: Focus on Agomelatine - springermedizin.de
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Novel melatonin-based treatments for major depression - The Lancet
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Update on Depression Treatments for Youth - Psychiatric Times
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Novel melatonin-based treatments for major depression – Authors' reply - The Lancet
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Antibiotic resistance: Antidepressants an ‘overlooked phenomenon’ - Royal Australian College of General Practitioners (RACGP)
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These Antidepressants Are Most Effective, Study Says - Time Magazine
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Are high-speed antidepressants as sweet as they sound? - The Conversation
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Major study backs efficacy of antidepressants - PharmaTimes
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A new review study compares 21 antidepressants. - Psychology Today
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Comparative efficacy and acceptability of 21 antidepressant drugs for the acute treatment of adults with major depressive disorder: a systematic review and network meta-analysis - The Lancet
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'Whatever the medication is doing, it's keeping me going' - BBC
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Agomelatine and escitalopram equally effective for treatment of anxiety - Medical Dialogues
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Taking an antidepressant? Mixing it with other medicines – including some cold and flu treatments – can be dangerous - Yahoo News Australia
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Government cancels approval for antidepressant Valdoxan - koreabiomed.com
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Perimenopausal depression challenging to diagnose - Royal Australian College of General Practitioners (RACGP)
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Antidepressants: More Toxic to Liver Than Previously Thought? - hepmag.com
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Study of big pharma's education events for doctors raises concerns about overtreatment - Australian Broadcasting Corporation
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A new approach to managing depression - Irish Medical Times
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How drugs like Prozac, Sertaline and Cipralex could be making antibiotics less effective - The i Paper
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Turning on to psychedelics: fear and loathing no more - Medical Republic
Why This Topic Is Trending
This topic has recently gained attention due to increased public interest. Search activity and Wikipedia pageviews suggest growing global engagement.
Search Interest & Related Topics
Search interest data over the past 12 months indicates that this topic periodically attracts global attention. Sudden spikes often correlate with major news events, public statements, or geopolitical developments.