Why is "Alkaline phosphatase" trending?
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- Date: 2026-03-15 06:34:51
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Wikipedia Overview
The enzyme alkaline phosphatase is a phosphatase with the physiological role of dephosphorylating compounds. The enzyme is found across a multitude of organisms, prokaryotes and eukaryotes alike, with the same general function, but in different structural forms suitable to the environment they function in. Alkaline phosphatase is found in the periplasmic space of E. coli bacteria. This enzyme is heat stable and has its maximum activity at high pH. In humans, it is found in many forms depending on its origin within the body – it plays an integral role in metabolism within the liver and development within the skeleton. Due to its widespread prevalence in these areas, its concentration in the bloodstream is used by diagnosticians as a biomarker in helping determine diagnoses such as hepatitis or osteomalacia.
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Search Interest Perspective
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Cadaverine modulates bovine alkaline phosphatase kinetics and structure: spectroscopic and bioinformatics study - Nature
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Why Your Alkaline Phosphatase Level Might Be Abnormal - Health: Trusted and Empathetic Health and Wellness Information
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Commentary: Association between albumin-to-alkaline phosphatase ratio and a 3-month unfavorable outcome in patients with acute ischemic stroke - Frontiers
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Alkaline Phosphatase-Activated NIR-II AIEgens Nanosystem for Surgical and Postoperative Closed-Loop Therapy of Advanced Osteosarcoma - Wiley
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Prognostic Value of the Pre-treatment Albumin-to-Alkaline Phosphatase Ratio in Patients With Metastatic Colorectal Cancer - Cureus
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Routine blood test may flag hidden osteoporosis risk, study finds - News-Medical
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Retrospective cohort study on alkaline phosphatase and ICU mortality rate of multiple myeloma - Nature
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Iron-nitrogen co-doped hollow porous carbon spheres for sensitive colorimetric sensing of alkaline phosphatase in complex biological samples - ScienceDirect.com
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Alkaline Phosphatase Predicts Short-term Postoperative Outcome in Adult Patients with Moyamoya Disease - Frontiers
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The Clinical Significance of Alkaline Phosphatase Levels in Multiple Myeloma - Cancer Nursing Today
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Sex-Specific Associations of Serum Alkaline Phosphatase With Metabolic Syndrome and Its Components: Over 15 Years of Follow-Up Among Iranian Adults - Wiley Online Library
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Evaluation of serum alkaline phosphatase and lactate dehydrogenase as predictive biomarkers for the prognosis of male breast cancer - Nature
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More Than Just Bone Pain: A Case of Paget’s Disease, Seropositive Rheumatoid Arthritis, and Metabolic Dysfunction-Associated Steatohepatitis (MASH) in a Patient With Elevated Alkaline Phosphatase (ALP) - Cureus
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The alkaline phosphatase-to-prealbumin ratio combined with CT-quantified sarcopenia predicts survival in gastric cancer patients after surgical resection - Frontiers
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Alkaline phosphatase-responsive peptide amphiphiles promote the apoptosis of HER2-positive breast cancer cells via enhanced drug delivery - ScienceDirect.com
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Association of alkaline-phosphatase/albumin ratio with all-cause mortality in critically ill patients with ischemic stroke: a retrospective study - Frontiers
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Multifunctionally diverse alkaline phosphatases of Alteromonas drive the phosphorus cycle in the ocean - Nature
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Association between changes in serum alkaline phosphatase levels and radiographic progression in ankylosing spondylitis - Nature
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A dataset of global ocean alkaline phosphatase activity - Nature
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Author Correction: Responsive photonic alginate hydrogel particles for the quantitative detection of alkaline phosphatase - Nature
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Prognostic value of serum alkaline phosphatase in spinal metastatic disease | British Journal of Cancer - Nature
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Over-Expression of Intestinal Alkaline Phosphatase Attenuates Atherosclerosis - American Heart Association Journals
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Association Between Alkaline Phosphatase and Muscle Mass, Strength, or Physical Performance in Patients on Maintenance Hemodialysis - Frontiers
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Recombinant Alkaline Phosphatase Prevents Acute on Chronic Liver Failure - Nature
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Associations of serum alkaline phosphatase level with all-cause and cardiovascular mortality in the general population - Frontiers
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Persistent Increase in Serum Alkaline Phosphatase in a Patient with Monoclonal Gammopathy of Undefined Significance - Wiley Online Library
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Alkaline phosphatase affects renal function in never-treated hypertensive patients: effect modification by age - Nature
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Alkaline phosphatase in clinical practice in childhood: Focus on rickets - Frontiers
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Alkaline Phosphatase, an Unconventional Immune Protein - Frontiers
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A new activity for an old enzyme: Escherichia coli bacterial alkaline phosphatase is a phosphite-dependent hydrogenase - PNAS
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Combined DeRitis ratio and alkaline phosphatase on the prediction of portal vein tumor thrombosis in patients with hepatocellular carcinoma - Nature
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Association between alkaline phosphatase to albumin ratio and mortality among patients with sepsis - Nature
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mInd the gAP: Intestinal Alkaline Phosphatase Puts the Breaks on Atherosclerosis - American Heart Association Journals
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Systemic inhibition of tissue-nonspecific alkaline phosphatase alters the brain-immune axis in experimental sepsis - Nature
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All-in-One Alkaline Phosphatase-Response Aggregation-Induced Emission Probe for Cancer Discriminative Imaging and Combinational Chemodynamic–Photodynamic Therapy - ACS Publications
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The structural pathology for hypophosphatasia caused by malfunctional tissue non-specific alkaline phosphatase - Nature
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Serum alkaline phosphatase relates to cardiovascular risk markers in children with high calcium-phosphorus product - Nature
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Clinical role of pretreatment albumin-to-alkaline phosphatase ratio in lung cancer: a meta-analysis - Nature
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The relationship between insulin resistance, serum alkaline phosphatase, and left ventricular dysfunction following myocardial infarction - Nature
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ESMO 2022: Alkaline Phosphatase Decline and Pain Response as Markers for OS in Patients with mCRPC Treated with Radium-223 in the REASSURE Study - UroToday
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Tumour-derived alkaline phosphatase regulates tumour growth, epithelial plasticity and disease-free survival in metastatic prostate cancer - Nature
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Intestinal Alkaline Phosphatase Exerts Anti-Inflammatory Effects Against Lipopolysaccharide by Inducing Autophagy - Nature
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Prognostic effect of albumin-to-alkaline phosphatase ratio on patients with hepatocellular carcinoma: a systematic review and meta-analysis - Nature
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The prognostic significance of Albumin-to-Alkaline Phosphatase Ratio in upper tract urothelial carcinoma - Nature
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The spatio-temporal distribution of alkaline phosphatase activity and phoD gene abundance and diversity in sediment of Sancha Lake - Nature
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Supplemented Alkaline Phosphatase Supports the Immune Response in Patients Undergoing Cardiac Surgery: Clinical and Computational Evidence - Frontiers
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Association Between Alkaline Phosphatase and Clinical Outcomes in Patients With Spontaneous Intracerebral Hemorrhage - Frontiers
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Interaction of genetic markers associated with serum alkaline phosphatase levels in the Japanese population - Nature
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The roles of serum alkaline and bone alkaline phosphatase levels in predicting heterotopic ossification following spinal cord injury - Nature
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Variable inter and intraspecies alkaline phosphatase activity within single cells of revived dinoflagellates - Nature
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Alkaline Phosphatase Threshold Marks Significant Fibrosis in Hepatitis B - Infectious Disease Advisor
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Association Between the Pretreatment Albumin-to-Alkaline Phosphatase Ratio and Clinical Outcomes in Patients With Bladder Cancer Treated With Radical Cystectomy: A Retrospective Cohort Study - Frontiers
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Responsive photonic alginate hydrogel particles for the quantitative detection of alkaline phosphatase - Nature
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Intestinal alkaline phosphatase (IAP, IAP Enhancer) attenuates intestinal inflammation and alleviates insulin resistance - Frontiers
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Intestinal Alkaline Phosphatase Deficiency Leads to Lipopolysaccharide Desensitization and Faster Weight Gain - ASM Journals
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The Correlation Between Alkaline Phosphatase Decline and Overall Survival in Men with Metastatic Castration-Resistant Prostate Cancer in the REASSURE Study - Nicholas James - UroToday
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A homozygous missense variant in the alkaline phosphatase gene ALPL is associated with a severe form of canine hypophosphatasia - Nature
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Rifampicin induces the bone form of alkaline phosphatase in humans - Wiley Online Library
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Circulating Placental Alkaline Phosphatase Expressing Exosomes in Maternal Blood Showed Temporal Regulation of Placental Genes - Frontiers
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Tissue Nonspecific Alkaline Phosphatase (TNAP) Regulates Cranial Base Growth and Synchondrosis Maturation - Frontiers
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Single-molecule diffusometry reveals no catalysis-induced diffusion enhancement of alkaline phosphatase as proposed by FCS experiments - PNAS
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Alkaline phosphatase is associated with vascular depression in patients with severe white matter hyperintensities - Frontiers
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Alkaline Phosphatase: Discovery and Naming of Our Favorite Enzyme - Wiley Online Library
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Incidental Finding of Extreme Elevation of Serum Alkaline Phosphatase in Pregnancy - Cureus
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Alkaline Phosphatase Treatment of Acute Kidney Injury in an Infant Piglet Model of Cardiopulmonary Bypass with Deep Hypothermic Circulatory Arrest - Nature
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Comparative chemical genomics in Babesia species identifies the alkaline phosphatase PhoD as a determinant of antiparasitic resistance - PNAS
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Diagnostic approach in dogs with increased ALP activity (Proceedings) - DVM360
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Dynamic consolidated bioprocessing for innovative lab-scale production of bacterial alkaline phosphatase from Bacillus paralicheniformis strain APSO - Nature
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Resolvin E1-induced intestinal alkaline phosphatase promotes resolution of inflammation through LPS detoxification - PNAS
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Prognostic values of serum alkaline phosphatase and globulin levels in patients undergoing intravenous thrombolysis - Frontiers
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The Role of Intestinal Alkaline Phosphatase in Inflammatory Disorders of Gastrointestinal Tract - Wiley Online Library
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A distinct, high-affinity, alkaline phosphatase facilitates occupation of P-depleted environments by marine picocyanobacteria - PNAS
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Development of a Nanobody–Alkaline Phosphatase Fusion Protein for Detection of SARS-CoV-2 Spike Protein in a Fluorescence Enzyme Immunoassay - ACS Publications
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Association of ALPL variants with serum alkaline phosphatase and bone traits in the general Japanese population: The Nagahama Study - Nature
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Degarelix controls serum alkaline phosphatase better than leuprolide - Nature
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Reassessment of alkaline phosphatase as serum tumor marker with high specificity in osteosarcoma - Wiley Online Library
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Ectopic Production of an Alkaline Phosphatase Isoenzyme in Patients with Cancer - The New England Journal of Medicine
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Necrotizing enterocolitis: a potential protective role for intestinal alkaline phosphatase as lipopolysaccharide detoxifying enzyme - Frontiers
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Correlation between high serum alkaline phosphatase levels and denosumab-related hypocalcemia in patients with multiple myeloma - Wiley Online Library
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Leukocyte Alkaline Phosphatase Activity in Rickets Due to Vitamin D Deficiency - The New England Journal of Medicine
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Effects of alfacalcidol on cardiovascular outcomes according to alkaline phosphatase levels in the J-DAVID trial - Nature
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A reusable copper-cysteamine fluorescence probe for cost-effective detection of alkaline phosphatase activity based on a redox-modulated inner filter effect - ScienceDirect.com
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Pain and health-related quality of life in patients with hypophosphatasemia with and without ALPL gene mutations - Frontiers
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mInd the gAP: Intestinal Alkaline Phosphatase Puts the Breaks on Atherosclerosis - American Heart Association Journals
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Alkaline Phosphatase: A Reliable Endogenous Partner for Drug Delivery and Diagnostics - Wiley
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Alkaline phosphatase in sepsis-induced AKI - Nature
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Biomarker monitors testosterone therapy for osteoporosis - Cornell Chronicle
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Intestinal alkaline phosphatase prevents metabolic syndrome in mice - PNAS
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phoD Alkaline Phosphatase Gene Diversity in Soil - ASM Journals
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Effects of Simvastatin on Gene Expression and Alkaline Phosphatase Activity in the MG-63 Cell Line Treated With Hyperglycemia for Bone Regeneration - Cureus
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Phosphorylated lipid-conjugated oligonucleotide selectively anchors on cell membranes with high alkaline phosphatase expression - Nature
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The alkaline phosphatase PhoX is more widely distributed in marine bacteria than the classical PhoA - Nature
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Parathyroid Hormone, Alkaline Phosphatase and Fibroblast Growth Factor 23 - Renal and Urology News
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Alkaline Phosphatase (ALP), Aspartate Aminotransferase (AST) and Alanine Aminotransferase (ALT) Activities in Selected Tissues of Rats Fed on Processed Atlantic Horse Mackerel ( Trachurus trachurus - SCIRP Open Access
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RESPONSE topline data: Seladelpar normalized alkaline phosphatase, reduced pruritus in PBC - Healio
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Osteogenic cocktail induces calcifications in human breast cancer cell line via placental alkaline phosphatase expression - Nature
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Comparative Study of Levels of Serum Bilirubin, Serum Transaminase, Serum Alkaline Phosphatase, and Prothrombin Time After Laparoscopic Cholecystectomy and Open Cholecystectomy - Cureus
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Innovative Drugs to Target Renal Inflammation in Sepsis: Alkaline Phosphatase - Frontiers
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A novel optical strategy for ALP detection and development of matched smartphone app - Nature
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Hypophosphatasia: Clinical updates and therapeutic advances - Mayo Clinic
Why This Topic Is Trending
This topic has recently gained attention due to increased public interest. Search activity and Wikipedia pageviews suggest growing global engagement.
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Search interest data over the past 12 months indicates that this topic periodically attracts global attention. Sudden spikes often correlate with major news events, public statements, or geopolitical developments.