Why is "Allosteric site" trending?

Search Interest Perspective

• A single allosteric site merges activation, modulation and inhibition in TRPM5 - Nature
• Identification of an allosteric site on the E3 ligase adapter cereblon - Nature
• Fluoxetine targets an allosteric site in the enterovirus 2C AAA+ ATPase and stabilizes a ring-shaped hexameric complex - Science | AAAS
• De novo design of protein condensation inhibitors by targeting an allosteric site of cGAS - Nature
• Druggable negative allosteric site of P2X3 receptors - PNAS
• Unlocking hidden pocket on a billion‑dollar drug target - Harvard Office of Technology Development
• Dynamic and structural insights into allosteric regulation on MKP5 a dual-specificity phosphatase - Nature
• Illumination of serotonin transporter mechanism and role of the allosteric site - Science | AAAS
• Targeting an allosteric site in dynamin-related protein 1 to inhibit Fis1-mediated mitochondrial dysfunction - Nature
• Antiviral activity of natural phenolic compounds in complex at an allosteric site of SARS-CoV-2 papain-like protease - Nature
• Integrative residue-intuitive machine learning and MD Approach to Unveil Allosteric Site and Mechanism for β2AR - Nature
• Inhibitors of BRAF dimers using an allosteric site - Nature
• RAS-inhibiting biologics identify and probe druggable pockets including an SII-α3 allosteric site - Nature
• Finely ordered intracellular domain harbors an allosteric site to modulate physiopathological function of P2X3 receptors - Nature
• Cheminformatics-aided discovery of potential allosteric site modulators of ubiquitin-specific protease 7 - Nature
• Inhibiting Mycobacterium tuberculosis CoaBC by targeting an allosteric site - Nature
• An allosteric site in the T-cell receptor Cβ domain plays a critical signalling role - Nature
• Allosteric Site Inhibitor Disrupting Auto-Processing of Malarial Cysteine Proteases - Nature
• A novel allosteric site in casein kinase 2α discovered using combining bioinformatics and biochemistry methods - Nature
• Tamsulosin ameliorates bone loss by inhibiting the release of Cl− through wedging into an allosteric site of TMEM16A - PNAS
• Identification of the pyridoxal 5′-phosphate allosteric site in human pyridox(am)ine 5′-phosphate oxidase - Wiley Online Library
• Linking ATP and allosteric sites to achieve superadditive binding with bivalent EGFR kinase inhibitors - Nature
• Targeting allosteric binding site in methylenetetrahydrofolate dehydrogenase 2 (MTHFD2) to identify natural product inhibitors via structure-based computational approach - Nature
• PASSer2.0: Accurate Prediction of Protein Allosteric Sites Through Automated Machine Learning - Frontiers
• Mixed-solvent molecular dynamics simulation-based discovery of a putative allosteric site on regulator of G protein signaling 4 - Wiley Online Library
• A common allosteric site and mechanism in caspases - PNAS
• Substrate docking to γ-secretase allows access of γ-secretase modulators to an allosteric site - Nature
• Discovery of an allosteric site in the caspases - PNAS
• Mapping allosteric communications within individual proteins - Nature
• Drug hunters explore allostery’s advantages - C&EN
• Xanomeline displays concomitant orthosteric and allosteric binding modes at the M - Nature
• PASSerRank: Prediction of allosteric sites with learning to rank - Tian - 2023 - Journal of Computational Chemistry - Wiley Online Library
• Inhibitors of the Herbicidal Target IspD: Allosteric Site Binding - Wiley Online Library
• Analysis of tractable allosteric sites in G protein-coupled receptors - Nature
• Discovery of multiple hidden allosteric sites by combining Markov state models and experiments - PNAS
• Selective binding modes and allosteric inhibitory effects of lupane triterpenes on protein tyrosine phosphatase 1B - Nature