Why is "Alpha-2-Macroglobulin" trending?
Latest news, Wikipedia summary, and trend analysis.
Trend Analysis
- Ranking position: #
- Date: 2026-03-13 20:31:13
This topic has appeared in the trending rankings 1 time(s) in the past year. While it does not trend frequently, its appearance suggests a renewed or concentrated surge of public interest.
Based on Wikipedia pageviews and search interest, this topic gained significant attention on the selected date.
Trend Insight
This topic is not currently in the ranking.
Wikipedia Overview
α2-Macroglobulin (α2M) or alpha-2-macroglobulin is a large plasma protein found in the blood. It is mainly produced by the liver, and also locally synthesized by macrophages, fibroblasts, and adrenocortical cells. In humans it is encoded by the A2M gene.
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Trending Topic Today
Search Interest Perspective
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Label-Free Dynamic Single-Molecule Sensing of Alpha-2-Macroglobulin in Complex Matrices - ACS Publications
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Alpha 2-macroglobulin acts as a clearance factor in the lysosomal degradation of extracellular misfolded proteins - Nature
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Vets Examine New Alpha-2 Macroglobulin Joint Therapy for Horses - thehorse.com
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Novel heterozygous mutation in alpha-2-macroglobulin (A2M) suppressing the binding of amyloid-β (Aβ) - Frontiers
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Alpha‐2‐macroglobulin: A physiological guardian - Wiley Online Library
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Orthobiologics: New Hope For Treating Equine Asthma? - horsesport.com
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Alpha 2-Macroglobulin and Neuroinflammation in Acute Disseminated Encephalomyelitis - Neurology Advisor
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Metabolic glycoengineered exosome-A2M nanoplatform reprograms macrophage polarization and orchestrates bone regeneration in ONFH - Nature
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Intibio A2MG processing kit launched by Nupsala - vettimes.com
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Alpha-2-macroglobulin prevents platelet aggregation induced by Brain-Derived Neurotrophic Factor - ScienceDirect.com
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Novel role for alpha-2-macroglobulin (A2M) as a disease modifying protein in senile osteoporosis - Frontiers
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Evolution of protease activation and specificity via alpha-2-macroglobulin-mediated covalent capture - Nature
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-macroglobulin reveals mimicry of eukaryotic innate immunity - Nature
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Molecular form and concentration of serum α2-macroglobulin in diabetes - Scientific Reports - Nature
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-macroglobulin variants and interaction studies with recombinant G-related α - Nature
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Alpha-2 macroglobulin is genetically associated with Alzheimer disease - Nature
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Frozen fresh blood plasma preserves the functionality of native human α2-macroglobulin | Scientific Reports - Nature
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Assembly of an atypical α-macroglobulin complex from Pseudomonas aeruginosa - Nature
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Cryo-EM structures of human A2ML1 elucidate the protease-inhibitory mechanism of the A2M family - Nature
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Activated α2-Macroglobulin Regulates LRP1 Levels at the Plasma Membrane through the Activation of a Rab10-dependent Exocytic Pathway in Retinal Müller Glial Cells | Scientific Reports - Nature
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Alpha-2-macroglobulin from circulating exosome-like vesicles is increased in women with preterm pregnancies - Nature
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Alpha-2-macroglobulin in hemostasis and thrombosis: An underestimated old double-edged sword - Wiley Online Library
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Alpha-2 macroglobulin in Alzheimer’s disease: a marker of neuronal injury through the RCAN1 pathway - Nature
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The Age of Targeted Osteoarthritis Therapy Begins - Pharmacy Times
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-macroglobulin are associated with an increased risk of severe asthma exacerbations - Nature
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Activated α2-macroglobulin binding to cell surface GRP78 induces trophoblastic cell fusion | Scientific Reports - Nature
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Reply to Harwood et al.: Alternative functional conformations of native human α2-macroglobulin - pnas.org
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Hypochlorite-induced structural modifications enhance the chaperone activity of human α2-macroglobulin - pnas.org
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An α-2-macroglobulin insertion-deletion polymorphism in Alzheimer disease - Nature
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-macroglobulin, and soluble cellular prion protein have distinct co-receptor requirements for activation of cell-signaling - Nature
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A Unique Gene Module in Thermococcales Archaea Centered on a Hypervariable Protein Containing Immunoglobulin Domains - Frontiers
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New Research Provides Clarity Around the Treatment of Equine Osteoarthritis - EquiManagement
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Acute Phase Proteins Are Baseline Predictors of Tuberculosis Treatment Failure - Frontiers
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Rediscovering Beta-2 Microglobulin As a Biomarker across the Spectrum of Kidney Diseases - Frontiers
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Human pregnancy zone protein stabilizes misfolded proteins including preeclampsia- and Alzheimer’s-associated amyloid beta peptide - pnas.org
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Human PZP and common marmoset A2ML1 as pregnancy related proteins - Nature
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A complex of novel protease inhibitor, ovostatin homolog, with its cognate proteases in immature mice uterine luminal fluid - Nature
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Associations between the thyroid panel and serum protein concentrations across pregnancy - Nature
Why This Topic Is Trending
This topic has recently gained attention due to increased public interest. Search activity and Wikipedia pageviews suggest growing global engagement.
Search Interest & Related Topics
Search interest data over the past 12 months indicates that this topic periodically attracts global attention. Sudden spikes often correlate with major news events, public statements, or geopolitical developments.