Why is "Alteplase" trending?
Latest news, Wikipedia summary, and trend analysis.
Trend Analysis
- Ranking position: #
- Date: 2026-03-13 17:31:00
This topic has appeared in the trending rankings 1 time(s) in the past year. While it does not trend frequently, its appearance suggests a renewed or concentrated surge of public interest.
Based on Wikipedia pageviews and search interest, this topic gained significant attention on the selected date.
Trend Insight
Alteplase entered the ranking for the first time today at position #. This is its highest position ever recorded.
Trend History
This topic has appeared in the English Wikipedia rankings 1 time. It first appeared on 2026-03-13 and was most recently seen on 2026-03-13.
Wikipedia Overview
Alteplase, sold under the brand name Activase among others, is a biosynthetic form of human tissue-type plasminogen activator (t-PA). It is a thrombolytic medication used to treat acute ischemic stroke, acute ST-elevation myocardial infarction, pulmonary embolism associated with low blood pressure, and blocked central venous catheter. Alteplase is given by injection into a vein or artery. Alteplase is the same as the normal human plasminogen activator produced in vascular endothelial cells and is synthesized via recombinant DNA technology in Chinese hamster ovary cells (CHO). Alteplase causes the breakdown of a clot by inducing fibrinolysis.
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Trending Topic Today
Search Interest Perspective
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Intra-arterial alteplase after thrombectomy improves three-month functional recovery in large vessel stroke - 2 Minute Medicine
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Tenecteplase Unseats Low-Dose Alteplase Favored for Asian Patients - MedPage Today
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Add-On Alteplase May Aid Stroke Recovery Post-Thrombectomy - Medscape
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Timing-Dependent Cleavage of Interleukin-1 Receptor Antagonist by Alteplase Impairs Neuroprotection in Ischemic Stroke - American Heart Association Journals
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STRIVE: Low-Dose Alteplase Ineffective in STEMI Patients With Large Thrombus - TCTMD.com
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Catheter-Directed Alteplase Matches Urokinase for Treating Pulmonary Embolism - Docwire News
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Late-Breaking CHOICE 2 Data Indicate Alteplase Displayed Improved Stroke Recovery - NeurologyLive
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Giving post-thrombectomy alteplase within 24 hours of stroke onset shown to elevate clinical outcomes - NeuroNews International
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Post-thrombectomy alteplase linked to better stroke outcomes - News-Medical
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Intraarterial Alteplase After Thrombectomy May Improve Stroke Recovery: CHOICE2 - AJMC
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Caught in the Web: Alteplase-Assisted Rescue of an Entrapped Pericardial Pigtail - HMP Global Learning Network
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Infusion of clot-buster medication after clot removal may improve stroke recovery - www.heart.org
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Intralesional Alteplase as an Adjunct to Percutaneous Drainage for a Large Iliopsoas Muscle Hematoma in a Patient With Von Willebrand Disease: A Case Report - Cureus
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Alteplase before mechanical thrombectomy: which patients benefit from this bridging therapy? - Via Medica Journals
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Thrombolysis-to-Puncture Time Determines the Differential Effect of Tenecteplase Versus Alteplase in Large Vessel Occlusion - American Heart Association Journals
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CHOICE-2: IA Alteplase a Gamechanger for LVO Stroke? - Medscape
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HOPE Supports IV Alteplase in Late Window After Acute Ischemic Stroke - TCTMD.com
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#VisualAbstract: Alteplase Improves Outcomes in Acute Ischemic Stroke - 2 Minute Medicine
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Intravenous Tirofiban Versus Alteplase Before Endovascular Treatment in Acute Ischemic Stroke: A Pooled Analysis of the DEVT and RESCUE BT Trials - American Heart Association Journals
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CHOICE-2 Bolsters Intra-arterial Lytics After Stroke Thrombectomy - TCTMD.com
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Comparative Efficacy and Safety of Different Tenecteplase Doses With Alteplase in Acute Ischemic Stroke: A Systematic Review With Pairwise and Network Meta-Analysis to Determine the Optimal Dose - Wiley Online Library
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CATALYST-TNK interim analysis indicates non-inferiority of tenecteplase versus alteplase in ischaemic stroke - NeuroNews International
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HOPE Trial Results Show Patients Can Benefit From IVT Even After Traditional Window for Treatment - Neurology Today
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The Evaluation of Tenecteplase for the Treatment of an Ischemic Stroke - medRxiv
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Tenecteplase not associated with visual improvement in central retinal artery occlusion - 2 Minute Medicine
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Reduced-Dose Alteplase for Acute Pulmonary Embolism Achieves Similar Outcomes as Full-Dose With Less Bleeding - Physician's Weekly
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Stroke Trial Tips Scale Further to Favor Intra-Arterial Lytic After EVT - MedPage Today
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Heart Valve Surgery | Tenecteplase noninferior to alteplase for prosthetic valve thrombosis - springermedicine.com
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Tenecteplase Gains Ground as a Go-To Stroke Thrombolytic - Medscape
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Trial supports using clot-busting drug in late window after acute ischemic stroke - University of Cincinnati
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VisualAbstract: Tenecteplase is Non-Inferior to Alteplase for Acute Ischemic Stroke within 4.5 Hours of Onset - Physician's Weekly
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How Direct Relief and Boehringer Ingelheim Brought Advanced Stroke Treatment to 30 Low-Income Countries Around the Globe - Direct Relief
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Development of tenecteplase for stroke thrombolysis: Japan’s endeavor - Nature
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Alteplase given after clot removal may improve stroke recovery – study - NR Times
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Intra-Arterial Alteplase Safe but Fails to Improve Functional Outcome After Basilar Artery... - Medical Dialogues
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Boehringer launches Metalyse in Korea, bringing 1st new stroke thrombolytic option in 20 years - koreabiomed.com
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Intra-Arterial Alteplase After Thrombectomy May Improve large vessel Stroke Recovery: JAMA - Medical Dialogues
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Administration of Cilostazol Prior to Intravenous Alteplase for Acute Branch Atheromatous Disease: A Report of Three Cases - Wiley Online Library
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Reteplase versus Alteplase for Acute Ischemic Stroke - NEJM
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A Randomized Trial of Intravenous Alteplase before Endovascular Treatment for Stroke - NEJM
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Alteplase for Stroke With Unknown Onset Time in Chronic Kidney Disease: A Pooled Analysis of Individual Participant Data - American Heart Association Journals
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Alteplase for Acute Ischemic Stroke in Patients Aged >80 Years: - American Heart Association Journals
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Endovascular Thrombectomy with or without Intravenous Alteplase in Acute Stroke - NEJM
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Intravenous Alteplase Versus Best Medical Therapy for Patients With Minor Stroke: A Systematic Review and Meta-Analysis - American Heart Association Journals
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Low-Dose versus Standard-Dose Intravenous Alteplase in Acute Ischemic Stroke - NEJM
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Tenecteplase versus Alteplase before Thrombectomy for Ischemic Stroke - NEJM
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Delayed alteplase has clinical benefits in posterior circulation stroke outcomes - 2 Minute Medicine
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Intra-Arterial Alteplase After Successful Thrombectomy Linked to Better 90-Day Outcomes: JAMA - Medical Dialogues
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Evidence that Tenecteplase Is Noninferior to Alteplase for Acute Ischemic Stroke: - American Heart Association Journals
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Reteplase versus Alteplase for Acute Ischemic Stroke - NEJM
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Thrombolysis With Alteplase at 0.6 mg/kg for Stroke With Unknown Time of Onset: - American Heart Association Journals
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Haemorrhagic Pericardial Effusion Following Intrapleural Fibrinolysis Therapy With Alteplase/Dornase Alfa for Complicated Parapneumonic Effusion: A Case Report - Cureus
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Dual Antiplatelet Versus Alteplase for Early Neurologic Deterioration in Minor Stroke With Versus Without Large Vessel Occlusion: Prespecified Post Hoc Analysis of the ARAMIS Trial - American Heart Association Journals
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Thrombectomy alone versus intravenous alteplase plus thrombectomy in patients with stroke: an open-label, blinded-outcome, randomised non-inferiority trial - The Lancet
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Prospective Observational Cohort Study of Tenecteplase Versus Alteplase in Routine Clinical Practice | Stroke - American Heart Association Journals
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Consent-Related Outcomes in the Alteplase Compared to Tenecteplase Trial - Neurology® Journals
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Association of Time to Thrombolysis With Early Reperfusion After Alteplase and Tenecteplase in Patients With Large Vessel Occlusion - Neurology® Journals
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Tenecteplase versus alteplase in stroke thrombolysis: the last piece of the puzzle? - The Lancet
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Effect of Intravenous Alteplase Treatment on First-Line Stent Retriever Versus Aspiration Alone During Endovascular Treatment | Stroke - American Heart Association Journals
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Distal Thrombectomy Reconsidered: Lessons from DISTALS and ORIENTAL-MEVO - springermedicine.com
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Lack of Interactions Between Alteplase/Tenecteplase and the Adenosine A1R/A3R Agonist AST-004 - American Heart Association Journals
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Reteplase may be viable, less costly alternative vs. alteplase for treatment of stroke - Healio
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Boehringer Ingelheim wins Korea approval for Metalyse to treat acute ischemic stroke - koreabiomed.com
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Stroke - ATTEST-2 - British Heart Foundation
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Uric acid enhances alteplase-mediated thrombolysis as an antioxidant - Nature
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Clot-busting meds may be effective up to 24 hours after initial stroke symptoms - www.heart.org
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Tenecteplase Matches Alteplase for Ischemic Stroke Care - Medscape
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LVO Recanalization With Tenecteplase vs Alteplase - American Heart Association Journals
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One-Year Outcomes After Low-Dose Intracoronary Alteplase During Primary Percutaneous Coronary Intervention: - American Heart Association Journals
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Tenecteplase in Acute Stroke: What About the Children? - American Heart Association Journals
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Prourokinase Rivals Alteplase in Acute Stroke Treatment - Medscape
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Tenecteplase and alteplase demonstrate similar efficacy for acute ischemic stroke - 2 Minute Medicine
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VisualAbstract: Tenecteplase is Non-Inferior to Alteplase for Acute Ischemic Stroke within 4.5 Hours of Onset - 2 Minute Medicine
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Thrombolysis for Ischemic Stroke Beyond the 4.5-Hour Window: A Meta-Analysis of Randomized Clinical Trials - American Heart Association Journals
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Intravenous Tirofiban Versus Alteplase Before Endovascular Treatment in Acute Ischemic Stroke: A Pooled Analysis of the DEVT and RESCUE BT Trials - American Heart Association Journals
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A Randomized Trial of Tenecteplase versus Alteplase for Acute Ischemic Stroke - NEJM
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Dissolving porcine and human microthrombi by short exposure to microdoses of alteplase in an in vitro model of microvascular obstruction - Nature
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Tenecteplase vs Alteplase: Equal Mortality in Massive PE - Physician's Weekly
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Tenecteplase versus alteplase for thrombolysis in patients selected by use of perfusion imaging within 4·5 h of onset of ischaemic stroke (TASTE): a multicentre, randomised, controlled, phase 3 non-inferiority trial - The Lancet
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Predictors of the unfavorable outcomes in acute ischemic stroke patients treated with alteplase, a multi-center randomized trial - Nature
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Reteplase Superior to Alteplase in Chinese Stroke Trial - Medscape
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Thrombolytic Therapy in the Oldest Old: Successful Alteplase Administration in a 105-Year-Old Female With Ischemic Stroke - Cureus
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Making the Switch From Alteplase to Tenecteplase for Acute Ischemic Stroke - Cleveland Clinic
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Alteplase may be effective up to 24 hours after initial stroke symptom onset - NeuroNews International
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Intravenous tenecteplase compared with alteplase for acute ischaemic stroke in Canada (AcT): a pragmatic, multicentre, open-label, registry-linked, randomised, controlled, non-inferiority trial - The Lancet
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Phase III EXPECTS Trial Finds Alteplase Boosts 90-Day Recovery in Posterior Circulation Stroke Patients - Applied Clinical Trials Online
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Alteplase With Endovascular Thrombectomy Improves Functional Outcomes, Survival, but With Increased Risk of Symptomatic Intracranial Hemorrhage | NeurologyLive - Clinical Neurology News and Neurology Expert Insights - NeurologyLive
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Two Trials Boost Intra-arterial Lytics After Stroke Thrombectomy - TCTMD.com
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FDA Approves Clot-Dissolving Agent for Acute Ischemic Stroke in Adults - dicardiology.com
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Intraventricular alteplase use associated with a minimal reduction in parenchymal intracerebral hemorrhage volume in patients with intracerebral hemorrhage and intraventricular hemorrhage - 2 Minute Medicine
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Trial Favors Reteplase Over Alteplase in Improving Functional Outcomes in Patients with Ischemic Stroke - Applied Clinical Trials Online
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Factors Influencing Nerinetide Effect on Infarct Volume in Patients Without Alteplase in the Randomized ESCAPE-NA1 Trial | Stroke - American Heart Association Journals
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Safety, Functional Disability, Healthcare Utilization, and Quality-of-Life Outcomes in Elderly Receiving Alteplase and Tenecteplase: A Secondary Analysis From the AcT Trial | Stroke - American Heart Association Journals
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Tenecteplase Shows Similar Profile to Alteplase as First-Line Treatment for Large Vessel Occlusion Stroke - NeurologyLive
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Dual antiplatelet therapy is noninferior to alteplase for patients with minor nondisabling acute ischemic stroke – the ARAMIS trial - 2 Minute Medicine
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Anticoagulants in Acute Ischemic Stroke Patients Treated With Intravenous Alteplase - The Cardiology Advisor
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VisualAbstract: Thrombectomy alone is inferior to thrombectomy plus alteplase for acute ischemic stroke - 2 Minute Medicine
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The promise of tenecteplase in acute stroke: Within reach or beyond approval? - ScienceDirect.com
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Tenecteplase compares favorably to alteplase in new comparison of FDA-approved stroke drugs - Cardiovascular Business
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VisualAbstract: Dual antiplatelet therapy is noninferior to alteplase for patients with minor nondisabling acute ischemic stroke - 2 Minute Medicine
Why This Topic Is Trending
This topic has recently gained attention due to increased public interest. Search activity and Wikipedia pageviews suggest growing global engagement.
Search Interest & Related Topics
Search interest data over the past 12 months indicates that this topic periodically attracts global attention. Sudden spikes often correlate with major news events, public statements, or geopolitical developments.