Why is "Amide" trending?
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- Date: 2026-03-09 13:57:53
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Wikipedia Overview
In organic chemistry, an amide, also known as an organic amide or a carboxamide, is a compound with the general formula R−C(=O)−NR′R″, where R, R', and R″ represent any group, typically organyl groups or hydrogen atoms. The amide group is called a peptide bond when it is part of the main chain of a protein, and an isopeptide bond when it occurs in a side chain, as in asparagine and glutamine. It can be viewed as a derivative of a carboxylic acid with the hydroxyl group replaced by an amino group ; or, equivalently, an acyl (alkanoyl) group joined to an amino group.
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Search Interest Perspective
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Strong and recyclable bio-derived poly(ester amide) hot-melt adhesive - Nature
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Engineered aldehyde dehydrogenases for amide bond formation - Science | AAAS
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Engineered enzymes could boost amide bond-forming efficiency for drug synthesis - Chemistry World
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🧪 Acyclic amides and their salts - The Observatory of Economic Complexity
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Amide and Thioester Synthesis Via Oxidative Coupling of Alcohols with Amines or Thiols Using Alcohol Dehydrogenases - Wiley Online Library
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Engineered enzyme makes amides from aldehydes - C&EN
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Debondable polyurethane-inspired adhesives using malonate-formed amide chemistry - ScienceDirect.com
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Engineered enzymes enable greener one-pot amide synthesis for drug manufacturing - Phys.org
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Rapid amide ligation between α-halo acylsilanes and amines under aqueous conditions - Nature
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N-Acyl Benzisothiazolinones (N-acyl BITs) Enable Efficient Amide Bond Formation in Aqueous and Organic Media - ACS Publications
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Recent Advances in the Activation of Unactivated Tertiary Amide C–N Bonds - Wiley
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Reverse polarity of amide nitrogen enables expedient access to N -cyano amides - Nature
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Carbene–Metal–Amide Materials Design: Tailoring π -Extended Amides for High-Performance Organic Light-Emitting Diodes - Wiley
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DAST Enabled Synthesis of Fluorinated Amides and Fatty Acid Amides Including Drugs under Ambient Conditions - ACS Publications
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Efficient solvent-free amide synthesis via Ritter reaction catalyzed by a reusable Fe - Nature
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Steering Amide Synthesis from Acetonitrile by Electrochemically Derived Active Superoxide - Wiley Online Library
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Synthesis of DNA-Encoded Bicyclic Peptides via Cysteine-Promoted Cyclization and Amide Condensation Reaction - ACS Publications
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Ultrastable amide-like isoquinolone-linked covalent organic frameworks for accelerated photocatalytic single-electron transfer transformation - Nature
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Anomeric Amides: Valuable Reagents in Synthetic Organic Chemistry - Wiley Online Library
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A novel amide corrosion inhibitor derived from waste cooking oil for mild steel in hydrochloric acid - Nature
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Electrophilic Amide Activation under Mild Conditions Using 2,2,2-Trifluoroethyl Iodonium Salt: Access to Esters and Benzoxazoles - ACS Publications
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Deep learning generative model for conditional crystal structure prediction of sodium amide - Nature
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Silylative Amide to Nitrile Conversion Mediated by Simple Lanthanide–Organoamides: Scope and Mechanism - Wiley Online Library
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Soft magnetic hysteresis in a dysprosium amide–alkene complex up to 100 kelvin - Nature
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Pyrazole Amide Scaffolds in Agricultural Chemistry: From Molecular Design to Applications - ACS Publications
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Total Synthesis of Feglymycin Using Umpolung Amide Synthesis - Wiley Online Library
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Streamlined Deamination of Diverse Primary Amines Enabled by Anomeric Amide - Pan - Chinese Journal of Chemistry - Wiley Online Library
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Robust amide covalent organic framework aerogel for selective recovery of gold from e-waste - ScienceDirect.com
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N‐Heterocyclic Carbenes (NHCs): An Emerging Efficient Catalyst in Amide Bond Formation - Wiley
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Silicon frustrated Lewis pairs catalyse α-deuteration of amides and esters - Nature
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Lewis Acid-Catalyzed Direct Conversion of Carboxylic Acids into Primary Amides and Nitriles Using Bis(trimethylsilyl)amine - ACS Publications
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Spatially Flexible Multisite Amide Derivative Enhances the Performance of Inverted Perovskite Solar Cells and Modules - Wiley
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Direct synthesis of N-trifluoromethyl amides via photocatalytic trifluoromethylamidation - Nature
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Insertion of anthranilyl unit into inert amides: A facile route to oligoamides and cyclic peptides - Science | AAAS
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C─H Amination of Polypropylene with Sodium N‐Chloro‐Amides - Wiley Online Library
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Cobalt-Catalyzed Amide Synthesis from Alcohols: An Ammonia-Free Approach with Dihydrogen Release - Wiley
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Modular Synchronous Synthesis of Amides and α-Ketoamides Realized by Matching Electrolysis-Paired Tandems - Wiley Online Library
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Al3+ driven-hydrolysis of amide group presented in the interface between EVA and glass for the decapsulation of waste photovoltaic laminates - ScienceDirect.com
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Computational prediction for the formation of amides and thioamides in the gas phase interstellar medium - Frontiers
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Performance evaluation and application of plant-oil-based lubricants synthesized through amide and surface modifications - ScienceDirect.com
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Divergent alkynylative difunctionalization of amide bonds through C–O deoxygenation versus C–N deamination - Nature
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Low pressure amide hydrogenation enabled by magnetocatalysis - Nature
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Amide-to-ester substitution as a stable alternative to N -methylation for increasing membrane permeability in cyclic peptides - Nature
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Amide groups in 3.7 billion years old liquid inclusions - Nature
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Selective amide bond formation in redox-active coacervate protocells - Nature
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Photocatalytic Synthesis of Diaryl Amides via Direct Coupling of Methyl Arenes and Nitroarenes - ACS Publications
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Biosynthesis of poly(ester amide)s in engineered Escherichia coli - Nature
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Merging enzymes with chemocatalysis for amide bond synthesis - Nature
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An amide to thioamide substitution improves the permeability and bioavailability of macrocyclic peptides - Nature
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Challenges and Breakthroughs in Selective Amide Activation - Feng - 2022 - Angewandte Chemie International Edition - Wiley Online Library
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Rhodium catalyzed tunable amide homologation through a hook-and-slide strategy - Science | AAAS
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Thioester-mediated biocatalytic amide bond synthesis with in situ thiol recycling - Nature
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Discovery of Potent and Orally Bioavailable Pyrimidine Amide cGAS Inhibitors via Structure-Guided Hybridization - ACS Publications
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Amide C–N bonds activation by A new variant of bifunctional N-heterocyclic carbene - Nature
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Efficient synthesis of primary and secondary amides via reacting esters with alkali metal amidoboranes - Nature
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Enzyme Engineering for High-Yielding Amide Formation: Lipase-Catalyzed Synthesis of N -Acyl Glycines in Aqueous Media - Wiley Online Library
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Direct esterification of amides by the dimethylsulfate-mediated activation of amide C–N bonds - Nature
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Structure and function of the geldanamycin amide synthase from Streptomyces hygroscopicus - Nature
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C-terminal amides mark proteins for degradation via SCF–FBXO31 - Nature
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Synthesis of aromatic amides from lignin and its derivatives - Nature
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A green chemistry perspective on catalytic amide bond formation - Nature
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Enzymatic Cascades for Stereoselective and Regioselective Amide Bond Assembly - Wiley Online Library
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Visible Light-Induced Amide Bond Formation - ACS Publications
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Discovery, characterization and engineering of ligases for amide synthesis - Nature
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Triflylpyridinium as Coupling Reagent for Rapid Amide and Ester Synthesis - ACS Publications
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Amino-oxetanes as amide isosteres by an alternative defluorosulfonylative coupling of sulfonyl fluorides - Nature
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Interface chemistry of an amide electrolyte for highly reversible lithium metal batteries - Nature
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Copper assisted sequence-specific chemical protein conjugation at a single backbone amide - Nature
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Shifting Lithium Amide Reactivity to the Radical Domain: Regioselective Radical C−H Functionalization of 3‐Iodooxetane for the Synthesis of 1,5‐Dioxaspiro[2.3]hexanes - Natho - 2025 - Angewandte Chemie International Edition - Wiley Online Library
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Beyond Amide Bond Formation: TCFH as a Reagent for Esterification - ACS Publications
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Enantioselective synthesis of chiral amides by carbene insertion into amide N–H bond - Nature
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β-Silyl alkynoates: Versatile reagents for biocompatible and selective amide bond formation - Science | AAAS
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Metal and Photocatalyst-Free Amide Synthesis via Decarbonylative Condensation of Alkynes and Photoexcited Nitroarenes - ACS Publications
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Molecular basis for carrier protein-dependent amide bond formation in the biosynthesis of lincosamide antibiotics - Nature
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Deoxygenative photochemical alkylation of secondary amides enables a streamlined synthesis of substituted amines - Nature
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Cobalt-catalyzed synthesis of amides from alkenes and amines promoted by light - Science | AAAS
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A chemoenzymatic process for amide bond formation by an adenylating enzyme-mediated mechanism - Nature
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Metabolic Hydrolysis of Aromatic Amides in Selected Rat, Minipig, and Human In Vitro Systems - Nature
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Stable and ordered amide frameworks synthesised under reversible conditions which facilitate error checking - Nature
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Covalent Organic Framework Catalyzed Amide Synthesis Directly from Alcohol Under Red Light Excitation - Wiley Online Library
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One-Step Biocatalytic Synthesis of Sustainable Surfactants by Selective Amide Bond Formation - Wiley Online Library
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Atom-economic catalytic amide synthesis from amines and carboxylic acids activated in situ with acetylenes - Nature
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Strain-Release-Driven Modular Synthesis of Oxetane-Based Amide Bioisosteres: Concise, Robust and Scalable Approach - Wiley Online Library
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Unearthing the Mechanism of Umpolung Amide Synthesis - ScienceDirect.com
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Effect of amide protoporphyrin derivatives on immune response in Apis mellifera - Nature
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The Role of Hydroxycinnamic Acid Amide Pathway in Plant Immunity - Frontiers
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Amide-Directed Highly Enantioselective Hydrogenation of Diverse Acyclic Multisubstituted Alkenes Under Mild Conditions - Wiley Online Library
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Electrocatalytic Water Oxidation by Mononuclear Copper Complexes of Bis-amide Ligands with N4 Donor: Experimental and Theoretical Investigation - ACS Publications
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Enzyme and copper combo builds amide bonds - C&EN
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Homogeneous and heterogeneous catalytic reduction of amides and related compounds using molecular hydrogen - Nature
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Amide and Peptide Bond Formation in Water at Room Temperature - ACS Publications
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How amide hydrogens exchange in native proteins - PNAS
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Bifunctional Iminophosphorane Catalyzed Amide Enolization for Enantioselective Cyclohexadienone Desymmetrization - Wiley Online Library
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Streamlining the synthesis of amides using Nickel-based nanocatalysts - Nature
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Isoselenourea-Catalyzed Enantioselective Pyrazolo-Heterocycle Synthesis Enabled by Self-Correcting Amide and Ester Acylation - Wiley Online Library
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Amide Synthesis by Nickel/Photoredox-Catalyzed Direct Carbamoylation of (Hetero)Aryl Bromides - Wiley Online Library
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Amide Technologies Appoints Co-Founder and MIT Chemistry Professor as CEO - BioSpace
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Nickel-Catalyzed Reduction of Secondary and Tertiary Amides - ACS Publications
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Solvent Minimized Synthesis of Amides by Reactive Extrusion - Bolt - 2024 - Angewandte Chemie International Edition - Wiley Online Library
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Convergent Total Synthesis of Yaku'amide A - Cai - 2021 - Angewandte Chemie International Edition - Wiley Online Library
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